A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells

Chien Tien Chen, Yogesh S. Munot, Santosh B. Salunke, Yi Ching Wang, Ruo Kai Lin, Chun Cheng Lin, Chia Chun Chen, Y. Hsin Liu

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

A new Iri-antennary, galactoside-capped gallamide dendritic anchor with thiolate focal group is synthesized via click chemistry. The highly hydrophilic dendron was efficiently anchored onto the surface of CdSe/ZnS core/shell nanoparticles in a covalent fashion, as evidenced by 1H NMR spectrum of the resultant nanohybrid with intact core fluorescent property. The water-soluble nano-hybrid was found smoothly and selectively uptaken by lung cancer cells enriched with membrane-bound asialoprotein receptors in 2-3 h. as evidenced by confocal microscopic analysis. Furthermore, cancer cells that are undergoing active mitosis also tend to uptake the nanohybrids efficiently and remain sustainable in serum-containing medium for several days, which shed light on its application as a photodynamic drug carrier for apoptosis study.

Original languageEnglish
Pages (from-to)527-540
Number of pages14
JournalAdvanced Functional Materials
Volume18
Issue number4
DOIs
Publication statusPublished - Feb 22 2008
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Materials Science(all)
  • Condensed Matter Physics
  • Physics and Astronomy (miscellaneous)

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