Abstract
A new Iri-antennary, galactoside-capped gallamide dendritic anchor with thiolate focal group is synthesized via click chemistry. The highly hydrophilic dendron was efficiently anchored onto the surface of CdSe/ZnS core/shell nanoparticles in a covalent fashion, as evidenced by 1H NMR spectrum of the resultant nanohybrid with intact core fluorescent property. The water-soluble nano-hybrid was found smoothly and selectively uptaken by lung cancer cells enriched with membrane-bound asialoprotein receptors in 2-3 h. as evidenced by confocal microscopic analysis. Furthermore, cancer cells that are undergoing active mitosis also tend to uptake the nanohybrids efficiently and remain sustainable in serum-containing medium for several days, which shed light on its application as a photodynamic drug carrier for apoptosis study.
| Original language | English |
|---|---|
| Pages (from-to) | 527-540 |
| Number of pages | 14 |
| Journal | Advanced Functional Materials |
| Volume | 18 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Feb 22 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Materials Science(all)
- Condensed Matter Physics
- Physics and Astronomy (miscellaneous)
Cite this
A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells. / Chen, Chien Tien; Munot, Yogesh S.; Salunke, Santosh B.; Wang, Yi Ching; Lin, Ruo Kai; Lin, Chun Cheng; Chen, Chia Chun; Liu, Y. Hsin.
In: Advanced Functional Materials, Vol. 18, No. 4, 22.02.2008, p. 527-540.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells
AU - Chen, Chien Tien
AU - Munot, Yogesh S.
AU - Salunke, Santosh B.
AU - Wang, Yi Ching
AU - Lin, Ruo Kai
AU - Lin, Chun Cheng
AU - Chen, Chia Chun
AU - Liu, Y. Hsin
PY - 2008/2/22
Y1 - 2008/2/22
N2 - A new Iri-antennary, galactoside-capped gallamide dendritic anchor with thiolate focal group is synthesized via click chemistry. The highly hydrophilic dendron was efficiently anchored onto the surface of CdSe/ZnS core/shell nanoparticles in a covalent fashion, as evidenced by 1H NMR spectrum of the resultant nanohybrid with intact core fluorescent property. The water-soluble nano-hybrid was found smoothly and selectively uptaken by lung cancer cells enriched with membrane-bound asialoprotein receptors in 2-3 h. as evidenced by confocal microscopic analysis. Furthermore, cancer cells that are undergoing active mitosis also tend to uptake the nanohybrids efficiently and remain sustainable in serum-containing medium for several days, which shed light on its application as a photodynamic drug carrier for apoptosis study.
AB - A new Iri-antennary, galactoside-capped gallamide dendritic anchor with thiolate focal group is synthesized via click chemistry. The highly hydrophilic dendron was efficiently anchored onto the surface of CdSe/ZnS core/shell nanoparticles in a covalent fashion, as evidenced by 1H NMR spectrum of the resultant nanohybrid with intact core fluorescent property. The water-soluble nano-hybrid was found smoothly and selectively uptaken by lung cancer cells enriched with membrane-bound asialoprotein receptors in 2-3 h. as evidenced by confocal microscopic analysis. Furthermore, cancer cells that are undergoing active mitosis also tend to uptake the nanohybrids efficiently and remain sustainable in serum-containing medium for several days, which shed light on its application as a photodynamic drug carrier for apoptosis study.
UR - http://www.scopus.com/inward/record.url?scp=40549110600&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40549110600&partnerID=8YFLogxK
U2 - 10.1002/adfm.200700449
DO - 10.1002/adfm.200700449
M3 - Article
AN - SCOPUS:40549110600
VL - 18
SP - 527
EP - 540
JO - Advanced Materials for Optics and Electronics
JF - Advanced Materials for Optics and Electronics
SN - 1057-9257
IS - 4
ER -