A third, ''deep,'' compartment for phenothiazine drug disposition: A new look at an old problem

S. H. Curry, O. Y.P. Hu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Volunteers were given oral promazine doses, and blood and urine were collected for promazine assay for as long as was necessary for the drug to cease to be detectable. Postabsorption data were subjected to two- and three-compartment modeling. Renal clearance was calculated. Renal excretion data were analyzed by use of the sigma-minus method, which permits the calculation of the half-life in plasma from excretion data. The mean α-phase rate constant for plasma decay (plasma assays) was .0155 min-1. The mean β-phase rate constant for plasma decay (plasma assays) was .0046 min-1; the mean β-phase rate constant for plasma decay (urine assays) was .0056 min-1. The mean γ-phase rate constant for plasma decay (urine assays) was .00075 min-1. These data demonstrate the existence of a third, deep, distribution compartment from which promazine is released slowly and which is only detectable by means of excretion studies.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalPsychopharmacology Bulletin
Volume26
Issue number1
Publication statusPublished - Jan 1 1990
Externally publishedYes

Fingerprint

Promazine
Pharmaceutical Preparations
Urine
phenothiazine
Half-Life
Volunteers
Kidney

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

Cite this

A third, ''deep,'' compartment for phenothiazine drug disposition : A new look at an old problem. / Curry, S. H.; Hu, O. Y.P.

In: Psychopharmacology Bulletin, Vol. 26, No. 1, 01.01.1990, p. 95-98.

Research output: Contribution to journalArticle

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