A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy

Qunzhou Zhang, Shihong Shi, Yun Yen, Jimmy Brown, Joseph Quoc Ta, Anh D. Le

Research output: Contribution to journalArticle

155 Citations (Scopus)

Abstract

The potential role of cancer stem-like cells (CSCs) in chemoresistance of human oral squamous cell carcinoma (OSCC) was examined. A small subpopulation (1-2%) of CD133+ CSCs was identified in OSCC cell lines and tissues. These CD133+ CSCs possess higher clonogenicity, invasiveness, and increased in vivo tumorigenicity as compared to CD133- counterparts. Meanwhile, CD133+ CSCs were substantially resistant to standard chemotherapy, wherein both in vitro and in vivo treatment with paclitaxel resulted in a marked enrichment for CD133+ CSCs. Our data suggest that CD133+ cells represent a small subpopulation of CSCs that may contribute to chemoresistance in human OSCC.

Original languageEnglish
Pages (from-to)151-160
Number of pages10
JournalCancer Letters
Volume289
Issue number2
DOIs
Publication statusPublished - Mar 28 2010
Externally publishedYes

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Neoplastic Stem Cells
Squamous Cell Carcinoma
Drug Therapy
Paclitaxel
Cell Line

Keywords

  • CD133 cancer stem-like cell
  • Chemoresistance
  • Oral squamous cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy. / Zhang, Qunzhou; Shi, Shihong; Yen, Yun; Brown, Jimmy; Ta, Joseph Quoc; Le, Anh D.

In: Cancer Letters, Vol. 289, No. 2, 28.03.2010, p. 151-160.

Research output: Contribution to journalArticle

Zhang, Qunzhou ; Shi, Shihong ; Yen, Yun ; Brown, Jimmy ; Ta, Joseph Quoc ; Le, Anh D. / A subpopulation of CD133+ cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy. In: Cancer Letters. 2010 ; Vol. 289, No. 2. pp. 151-160.
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