A study on the association between carotid atherosclerosis and genetic polymorphisms of apolipoprotein E among various arsenic exposure people

Yi Li Chou, Shu Ti Chiou, Yu Mei Hsueh, Hung Yi Chiou, Chien Jen Chen

Research output: Contribution to journalArticle

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Abstract

Objectives: Arsenic exposure has been reported to induce not only cancers but also many vascular diseases including ischemic heart diseases, cerebrovascular diseases, peripheral vascular diseases, diabetes mellitus, and hypertension. The study aimed at investigating the association between genetic polymorphisms of apolipoprotein E and carotid atherosclerosis among people with different arsenic exposure levels. Methods: A total of 304 study subjects including 157 atherosclerosis patients and 147 healthy controls were recruited from the residents of Lanyang Basin. The carotid atherosclerosis was examined by Doppler ultrasonography and genetic polymorphisms of apolipoprotein E were determined by PCR-RFLP. Logistic regression model was used to obtain odds ratio and the 95% confidence interval for the association between carotid atherosclerosis and genetic polymorphism of apolipoprotain. Results: The data showed that lower risk of developing carotid atherosclerosis was associated with hypertension in high-arsenic exposed group than in low-arsenic exposed group (2.13, 1.04-4.32 V.S. 11.47, 1.37-95.83). Different apolipoprotein E (3/4, 4/4) genotypes have different risk of developing carotid atherosclerosis was observed in low-arsenic exposed group but not in high-arsenic exposed group. Conclusions: Higher risk of developing carotid atherosclerosis was associated with hypertension in low-arsenic exposed group than in high-arsenic exposed group. The higher risk of carotid atherosclerosis for study subjects without ε2 genotype of apolipoprotein were observed in low-arsenic exposed group than those in high-arsenic exposed group.

Original languageEnglish
Pages (from-to)365-371
Number of pages7
JournalTaiwan Journal of Public Health
Volume20
Issue number5
Publication statusPublished - 2001

Fingerprint

Carotid Artery Diseases
Arsenic
Apolipoproteins E
Genetic Polymorphisms
Hypertension
Logistic Models
Genotype
Apolipoprotein E3
Apolipoprotein E4
Cerebrovascular Disorders
Doppler Ultrasonography
Peripheral Vascular Diseases
Apolipoproteins
Vascular Diseases
Restriction Fragment Length Polymorphisms
Myocardial Ischemia
Atherosclerosis
Diabetes Mellitus
Odds Ratio
Confidence Intervals

Keywords

  • Apolipoprotein E
  • Atherosclerosis
  • Inorganic arsenic

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

A study on the association between carotid atherosclerosis and genetic polymorphisms of apolipoprotein E among various arsenic exposure people. / Chou, Yi Li; Chiou, Shu Ti; Hsueh, Yu Mei; Chiou, Hung Yi; Chen, Chien Jen.

In: Taiwan Journal of Public Health, Vol. 20, No. 5, 2001, p. 365-371.

Research output: Contribution to journalArticle

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AU - Chen, Chien Jen

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AB - Objectives: Arsenic exposure has been reported to induce not only cancers but also many vascular diseases including ischemic heart diseases, cerebrovascular diseases, peripheral vascular diseases, diabetes mellitus, and hypertension. The study aimed at investigating the association between genetic polymorphisms of apolipoprotein E and carotid atherosclerosis among people with different arsenic exposure levels. Methods: A total of 304 study subjects including 157 atherosclerosis patients and 147 healthy controls were recruited from the residents of Lanyang Basin. The carotid atherosclerosis was examined by Doppler ultrasonography and genetic polymorphisms of apolipoprotein E were determined by PCR-RFLP. Logistic regression model was used to obtain odds ratio and the 95% confidence interval for the association between carotid atherosclerosis and genetic polymorphism of apolipoprotain. Results: The data showed that lower risk of developing carotid atherosclerosis was associated with hypertension in high-arsenic exposed group than in low-arsenic exposed group (2.13, 1.04-4.32 V.S. 11.47, 1.37-95.83). Different apolipoprotein E (3/4, 4/4) genotypes have different risk of developing carotid atherosclerosis was observed in low-arsenic exposed group but not in high-arsenic exposed group. Conclusions: Higher risk of developing carotid atherosclerosis was associated with hypertension in low-arsenic exposed group than in high-arsenic exposed group. The higher risk of carotid atherosclerosis for study subjects without ε2 genotype of apolipoprotein were observed in low-arsenic exposed group than those in high-arsenic exposed group.

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