A study of radiotherapy modalities combined with continuous 5-FU infusion for locally advanced gastrointestinal malignancies

S. I. Shibata, R. Pezner, D. Chu, J. H. Doroshow, W. A. Chow, L. A. Leong, K. A. Margolin, M. V. McNamara, R. J. Morgan, J. W. Raschko, G. Somlo, M. L. Tetef, Y. Yen, T. W. Synold, L. Wagman, N. Vora, M. Carroll, S. Lin, J. Longmate

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim. We describe the feasibility of combining infusional 5-fluorouracil (5-FU) with intraoperative radiation therapy (IORT). Methods. Patients with surgically resectable locally advanced gastrointestinal cancers were treated concurrently during surgery with IORT and a 72 h infusion of 5-FU. Patients without previous external beam radiation therapy (EBRT) were subsequently treated with EBRT (40-50 Gy) concurrent with a 21-day continuous infusion of 5-FU. Pancreatic, gastric, duodenal, ampullary, recurrent colorectal, and recurrent anal cancer were included. Results. During IORT/5-FU, no chemotherapy-related grade III or IV hematologic or gastrointestinal toxicity was noted. Post-surgical recovery or wound healing was not affected. One of nine patients who received post-operative radiation required a treatment break. During follow-up, there were more complications in patients with pelvic tumours, especially those with previous radiation. Nine patients have had local and/or local regional recurrences, two of these in the IORT field. Conclusions. Treatment with a combination of IORT and 5-FU followed by EBRT and 5-FU is feasible. However, long-term complications may be increased in previously irradiated recurrent pelvic tumours.

Original languageEnglish
Pages (from-to)650-657
Number of pages8
JournalEuropean Journal of Surgical Oncology
Volume30
Issue number6
DOIs
Publication statusPublished - Aug 1 2004
Externally publishedYes

Fingerprint

Fluorouracil
Radiotherapy
Neoplasms
Radiation
Anus Neoplasms
Gastrointestinal Neoplasms
Wound Healing
Stomach
Recurrence
Drug Therapy
Therapeutics

Keywords

  • Colorectal cancer
  • Intraoperative radiation therapy
  • Pancreatic cancer
  • Radiation sensitization

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

A study of radiotherapy modalities combined with continuous 5-FU infusion for locally advanced gastrointestinal malignancies. / Shibata, S. I.; Pezner, R.; Chu, D.; Doroshow, J. H.; Chow, W. A.; Leong, L. A.; Margolin, K. A.; McNamara, M. V.; Morgan, R. J.; Raschko, J. W.; Somlo, G.; Tetef, M. L.; Yen, Y.; Synold, T. W.; Wagman, L.; Vora, N.; Carroll, M.; Lin, S.; Longmate, J.

In: European Journal of Surgical Oncology, Vol. 30, No. 6, 01.08.2004, p. 650-657.

Research output: Contribution to journalArticle

Shibata, SI, Pezner, R, Chu, D, Doroshow, JH, Chow, WA, Leong, LA, Margolin, KA, McNamara, MV, Morgan, RJ, Raschko, JW, Somlo, G, Tetef, ML, Yen, Y, Synold, TW, Wagman, L, Vora, N, Carroll, M, Lin, S & Longmate, J 2004, 'A study of radiotherapy modalities combined with continuous 5-FU infusion for locally advanced gastrointestinal malignancies', European Journal of Surgical Oncology, vol. 30, no. 6, pp. 650-657. https://doi.org/10.1016/j.ejso.2003.11.012
Shibata, S. I. ; Pezner, R. ; Chu, D. ; Doroshow, J. H. ; Chow, W. A. ; Leong, L. A. ; Margolin, K. A. ; McNamara, M. V. ; Morgan, R. J. ; Raschko, J. W. ; Somlo, G. ; Tetef, M. L. ; Yen, Y. ; Synold, T. W. ; Wagman, L. ; Vora, N. ; Carroll, M. ; Lin, S. ; Longmate, J. / A study of radiotherapy modalities combined with continuous 5-FU infusion for locally advanced gastrointestinal malignancies. In: European Journal of Surgical Oncology. 2004 ; Vol. 30, No. 6. pp. 650-657.
@article{ab3d8830a22b4583bd2bc3f1cbf9f103,
title = "A study of radiotherapy modalities combined with continuous 5-FU infusion for locally advanced gastrointestinal malignancies",
abstract = "Aim. We describe the feasibility of combining infusional 5-fluorouracil (5-FU) with intraoperative radiation therapy (IORT). Methods. Patients with surgically resectable locally advanced gastrointestinal cancers were treated concurrently during surgery with IORT and a 72 h infusion of 5-FU. Patients without previous external beam radiation therapy (EBRT) were subsequently treated with EBRT (40-50 Gy) concurrent with a 21-day continuous infusion of 5-FU. Pancreatic, gastric, duodenal, ampullary, recurrent colorectal, and recurrent anal cancer were included. Results. During IORT/5-FU, no chemotherapy-related grade III or IV hematologic or gastrointestinal toxicity was noted. Post-surgical recovery or wound healing was not affected. One of nine patients who received post-operative radiation required a treatment break. During follow-up, there were more complications in patients with pelvic tumours, especially those with previous radiation. Nine patients have had local and/or local regional recurrences, two of these in the IORT field. Conclusions. Treatment with a combination of IORT and 5-FU followed by EBRT and 5-FU is feasible. However, long-term complications may be increased in previously irradiated recurrent pelvic tumours.",
keywords = "Colorectal cancer, Intraoperative radiation therapy, Pancreatic cancer, Radiation sensitization",
author = "Shibata, {S. I.} and R. Pezner and D. Chu and Doroshow, {J. H.} and Chow, {W. A.} and Leong, {L. A.} and Margolin, {K. A.} and McNamara, {M. V.} and Morgan, {R. J.} and Raschko, {J. W.} and G. Somlo and Tetef, {M. L.} and Y. Yen and Synold, {T. W.} and L. Wagman and N. Vora and M. Carroll and S. Lin and J. Longmate",
year = "2004",
month = "8",
day = "1",
doi = "10.1016/j.ejso.2003.11.012",
language = "English",
volume = "30",
pages = "650--657",
journal = "European Journal of Surgical Oncology",
issn = "0748-7983",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - A study of radiotherapy modalities combined with continuous 5-FU infusion for locally advanced gastrointestinal malignancies

AU - Shibata, S. I.

AU - Pezner, R.

AU - Chu, D.

AU - Doroshow, J. H.

AU - Chow, W. A.

AU - Leong, L. A.

AU - Margolin, K. A.

AU - McNamara, M. V.

AU - Morgan, R. J.

AU - Raschko, J. W.

AU - Somlo, G.

AU - Tetef, M. L.

AU - Yen, Y.

AU - Synold, T. W.

AU - Wagman, L.

AU - Vora, N.

AU - Carroll, M.

AU - Lin, S.

AU - Longmate, J.

PY - 2004/8/1

Y1 - 2004/8/1

N2 - Aim. We describe the feasibility of combining infusional 5-fluorouracil (5-FU) with intraoperative radiation therapy (IORT). Methods. Patients with surgically resectable locally advanced gastrointestinal cancers were treated concurrently during surgery with IORT and a 72 h infusion of 5-FU. Patients without previous external beam radiation therapy (EBRT) were subsequently treated with EBRT (40-50 Gy) concurrent with a 21-day continuous infusion of 5-FU. Pancreatic, gastric, duodenal, ampullary, recurrent colorectal, and recurrent anal cancer were included. Results. During IORT/5-FU, no chemotherapy-related grade III or IV hematologic or gastrointestinal toxicity was noted. Post-surgical recovery or wound healing was not affected. One of nine patients who received post-operative radiation required a treatment break. During follow-up, there were more complications in patients with pelvic tumours, especially those with previous radiation. Nine patients have had local and/or local regional recurrences, two of these in the IORT field. Conclusions. Treatment with a combination of IORT and 5-FU followed by EBRT and 5-FU is feasible. However, long-term complications may be increased in previously irradiated recurrent pelvic tumours.

AB - Aim. We describe the feasibility of combining infusional 5-fluorouracil (5-FU) with intraoperative radiation therapy (IORT). Methods. Patients with surgically resectable locally advanced gastrointestinal cancers were treated concurrently during surgery with IORT and a 72 h infusion of 5-FU. Patients without previous external beam radiation therapy (EBRT) were subsequently treated with EBRT (40-50 Gy) concurrent with a 21-day continuous infusion of 5-FU. Pancreatic, gastric, duodenal, ampullary, recurrent colorectal, and recurrent anal cancer were included. Results. During IORT/5-FU, no chemotherapy-related grade III or IV hematologic or gastrointestinal toxicity was noted. Post-surgical recovery or wound healing was not affected. One of nine patients who received post-operative radiation required a treatment break. During follow-up, there were more complications in patients with pelvic tumours, especially those with previous radiation. Nine patients have had local and/or local regional recurrences, two of these in the IORT field. Conclusions. Treatment with a combination of IORT and 5-FU followed by EBRT and 5-FU is feasible. However, long-term complications may be increased in previously irradiated recurrent pelvic tumours.

KW - Colorectal cancer

KW - Intraoperative radiation therapy

KW - Pancreatic cancer

KW - Radiation sensitization

UR - http://www.scopus.com/inward/record.url?scp=4043117787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4043117787&partnerID=8YFLogxK

U2 - 10.1016/j.ejso.2003.11.012

DO - 10.1016/j.ejso.2003.11.012

M3 - Article

VL - 30

SP - 650

EP - 657

JO - European Journal of Surgical Oncology

JF - European Journal of Surgical Oncology

SN - 0748-7983

IS - 6

ER -