A study of radiotherapy modalities combined with continuous 5-FU infusion for locally advanced gastrointestinal malignancies

S. I. Shibata, R. Pezner, D. Chu, J. H. Doroshow, W. A. Chow, L. A. Leong, K. A. Margolin, M. V. McNamara, R. J. Morgan, J. W. Raschko, G. Somlo, M. L. Tetef, Y. Yen, T. W. Synold, L. Wagman, N. Vora, M. Carroll, S. Lin, J. Longmate

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2 Citations (Scopus)

Abstract

Aim. We describe the feasibility of combining infusional 5-fluorouracil (5-FU) with intraoperative radiation therapy (IORT). Methods. Patients with surgically resectable locally advanced gastrointestinal cancers were treated concurrently during surgery with IORT and a 72 h infusion of 5-FU. Patients without previous external beam radiation therapy (EBRT) were subsequently treated with EBRT (40-50 Gy) concurrent with a 21-day continuous infusion of 5-FU. Pancreatic, gastric, duodenal, ampullary, recurrent colorectal, and recurrent anal cancer were included. Results. During IORT/5-FU, no chemotherapy-related grade III or IV hematologic or gastrointestinal toxicity was noted. Post-surgical recovery or wound healing was not affected. One of nine patients who received post-operative radiation required a treatment break. During follow-up, there were more complications in patients with pelvic tumours, especially those with previous radiation. Nine patients have had local and/or local regional recurrences, two of these in the IORT field. Conclusions. Treatment with a combination of IORT and 5-FU followed by EBRT and 5-FU is feasible. However, long-term complications may be increased in previously irradiated recurrent pelvic tumours.

Original languageEnglish
Pages (from-to)650-657
Number of pages8
JournalEuropean Journal of Surgical Oncology
Volume30
Issue number6
DOIs
Publication statusPublished - Aug 1 2004
Externally publishedYes

Keywords

  • Colorectal cancer
  • Intraoperative radiation therapy
  • Pancreatic cancer
  • Radiation sensitization

ASJC Scopus subject areas

  • Surgery
  • Oncology

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    Shibata, S. I., Pezner, R., Chu, D., Doroshow, J. H., Chow, W. A., Leong, L. A., Margolin, K. A., McNamara, M. V., Morgan, R. J., Raschko, J. W., Somlo, G., Tetef, M. L., Yen, Y., Synold, T. W., Wagman, L., Vora, N., Carroll, M., Lin, S., & Longmate, J. (2004). A study of radiotherapy modalities combined with continuous 5-FU infusion for locally advanced gastrointestinal malignancies. European Journal of Surgical Oncology, 30(6), 650-657. https://doi.org/10.1016/j.ejso.2003.11.012