A study of patients with chronic idiopathic urticaria from a medical center in northern Taiwan

Jeng Feng Chen, Min Huey Chung, Ying Chun Liu, Wei Ming Wang

Research output: Contribution to journalArticle

Abstract

Background: Chronic idiopathic urticaria (CIU) is a common dermatological disorder which significantly affects the quality of life of patients worldwide. This study investigates the demographic features, laboratory findings and the response to treatment of CIU patients prospectively in a medical center in northern Taiwan. Methods and Results: Thirtythree patients (15 females, 18 males, median age 32.79 years) with CIU were included according to the protocal approved for this study. A laboratory survey, including complete blood cells (CBC) with differential count, erythrocyte sedimentation rate (ESR), biochemistry panels, autoimmune profiles, thyroid function and multiple allergy simultaneous test (MAST) were conducted and analyzed before and after once daily monotherapy with levocetirizine 5mg. In addition, therapeutic efficacy was also assessed using mean pruritus score (MPS) and the mean number of wheals (MNW) score. The most commonly found reactive agents in the specific allergen test were mite DF (18/33 subjects, 54.4%) and mite DP (18/33 subjects, 54.4%). No significant difference was noted before and after levocetirizine monotherapy in terms of CBC, AST, ALT, BUN, creatinine, and ESR. Furthermore, the result of the MAST was also not affected by levocetirizine treatment. Compared to the therapeutic outcome measured on day-8, administration of antihistamine treatment significantly decreased MPS and MNW scores during day-22, day-29, and day-30. Consistently, the mean scores of MPS and MNW were significantly lower on day-36 than on day-8 within the same IgE level. Conclusions: Most of the patients in this study experienced satisfactory clinical improvement after once daily monotherapy with levocetirizine 5mg, whereas the antihistamine treatment did not result in a statistically significant change in the laboratory investigations. This study demonstrates that exhaustive investigations may not be necessary for patients with CIU and should be reserved for individuals following acquisition of a detailed history and physical examination. However, the monotherapy with low-sedative levocetirizine demonstrated a good clinical efficacy and did not significantly alter the laboratory parameters including the result of MAST. Therefore, it is suggested that MAST be included for checking which allergens should be avoided.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalJournal of Medical Sciences (Taiwan)
Volume32
Issue number5
Publication statusPublished - Oct 20 2012

Fingerprint

Urticaria
Taiwan
Hypersensitivity
Pruritus
Mites
Histamine Antagonists
Blood Sedimentation
Allergens
Blood Cells
Therapeutics
Blood Urea Nitrogen
Hypnotics and Sedatives
Biochemistry
Immunoglobulin E
Physical Examination
Creatinine
Thyroid Gland
History
Quality of Life
Demography

Keywords

  • Chronic idiopathic urticaria
  • Laboratory investigation
  • Levocetirizine
  • Therapeutic efficacy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A study of patients with chronic idiopathic urticaria from a medical center in northern Taiwan. / Chen, Jeng Feng; Chung, Min Huey; Liu, Ying Chun; Wang, Wei Ming.

In: Journal of Medical Sciences (Taiwan), Vol. 32, No. 5, 20.10.2012, p. 233-238.

Research output: Contribution to journalArticle

@article{6ddf9cb859a841e5b9b88b423d78f289,
title = "A study of patients with chronic idiopathic urticaria from a medical center in northern Taiwan",
abstract = "Background: Chronic idiopathic urticaria (CIU) is a common dermatological disorder which significantly affects the quality of life of patients worldwide. This study investigates the demographic features, laboratory findings and the response to treatment of CIU patients prospectively in a medical center in northern Taiwan. Methods and Results: Thirtythree patients (15 females, 18 males, median age 32.79 years) with CIU were included according to the protocal approved for this study. A laboratory survey, including complete blood cells (CBC) with differential count, erythrocyte sedimentation rate (ESR), biochemistry panels, autoimmune profiles, thyroid function and multiple allergy simultaneous test (MAST) were conducted and analyzed before and after once daily monotherapy with levocetirizine 5mg. In addition, therapeutic efficacy was also assessed using mean pruritus score (MPS) and the mean number of wheals (MNW) score. The most commonly found reactive agents in the specific allergen test were mite DF (18/33 subjects, 54.4{\%}) and mite DP (18/33 subjects, 54.4{\%}). No significant difference was noted before and after levocetirizine monotherapy in terms of CBC, AST, ALT, BUN, creatinine, and ESR. Furthermore, the result of the MAST was also not affected by levocetirizine treatment. Compared to the therapeutic outcome measured on day-8, administration of antihistamine treatment significantly decreased MPS and MNW scores during day-22, day-29, and day-30. Consistently, the mean scores of MPS and MNW were significantly lower on day-36 than on day-8 within the same IgE level. Conclusions: Most of the patients in this study experienced satisfactory clinical improvement after once daily monotherapy with levocetirizine 5mg, whereas the antihistamine treatment did not result in a statistically significant change in the laboratory investigations. This study demonstrates that exhaustive investigations may not be necessary for patients with CIU and should be reserved for individuals following acquisition of a detailed history and physical examination. However, the monotherapy with low-sedative levocetirizine demonstrated a good clinical efficacy and did not significantly alter the laboratory parameters including the result of MAST. Therefore, it is suggested that MAST be included for checking which allergens should be avoided.",
keywords = "Chronic idiopathic urticaria, Laboratory investigation, Levocetirizine, Therapeutic efficacy",
author = "Chen, {Jeng Feng} and Chung, {Min Huey} and Liu, {Ying Chun} and Wang, {Wei Ming}",
year = "2012",
month = "10",
day = "20",
language = "English",
volume = "32",
pages = "233--238",
journal = "Journal of Medical Sciences",
issn = "1011-4564",
publisher = "國防醫學院",
number = "5",

}

TY - JOUR

T1 - A study of patients with chronic idiopathic urticaria from a medical center in northern Taiwan

AU - Chen, Jeng Feng

AU - Chung, Min Huey

AU - Liu, Ying Chun

AU - Wang, Wei Ming

PY - 2012/10/20

Y1 - 2012/10/20

N2 - Background: Chronic idiopathic urticaria (CIU) is a common dermatological disorder which significantly affects the quality of life of patients worldwide. This study investigates the demographic features, laboratory findings and the response to treatment of CIU patients prospectively in a medical center in northern Taiwan. Methods and Results: Thirtythree patients (15 females, 18 males, median age 32.79 years) with CIU were included according to the protocal approved for this study. A laboratory survey, including complete blood cells (CBC) with differential count, erythrocyte sedimentation rate (ESR), biochemistry panels, autoimmune profiles, thyroid function and multiple allergy simultaneous test (MAST) were conducted and analyzed before and after once daily monotherapy with levocetirizine 5mg. In addition, therapeutic efficacy was also assessed using mean pruritus score (MPS) and the mean number of wheals (MNW) score. The most commonly found reactive agents in the specific allergen test were mite DF (18/33 subjects, 54.4%) and mite DP (18/33 subjects, 54.4%). No significant difference was noted before and after levocetirizine monotherapy in terms of CBC, AST, ALT, BUN, creatinine, and ESR. Furthermore, the result of the MAST was also not affected by levocetirizine treatment. Compared to the therapeutic outcome measured on day-8, administration of antihistamine treatment significantly decreased MPS and MNW scores during day-22, day-29, and day-30. Consistently, the mean scores of MPS and MNW were significantly lower on day-36 than on day-8 within the same IgE level. Conclusions: Most of the patients in this study experienced satisfactory clinical improvement after once daily monotherapy with levocetirizine 5mg, whereas the antihistamine treatment did not result in a statistically significant change in the laboratory investigations. This study demonstrates that exhaustive investigations may not be necessary for patients with CIU and should be reserved for individuals following acquisition of a detailed history and physical examination. However, the monotherapy with low-sedative levocetirizine demonstrated a good clinical efficacy and did not significantly alter the laboratory parameters including the result of MAST. Therefore, it is suggested that MAST be included for checking which allergens should be avoided.

AB - Background: Chronic idiopathic urticaria (CIU) is a common dermatological disorder which significantly affects the quality of life of patients worldwide. This study investigates the demographic features, laboratory findings and the response to treatment of CIU patients prospectively in a medical center in northern Taiwan. Methods and Results: Thirtythree patients (15 females, 18 males, median age 32.79 years) with CIU were included according to the protocal approved for this study. A laboratory survey, including complete blood cells (CBC) with differential count, erythrocyte sedimentation rate (ESR), biochemistry panels, autoimmune profiles, thyroid function and multiple allergy simultaneous test (MAST) were conducted and analyzed before and after once daily monotherapy with levocetirizine 5mg. In addition, therapeutic efficacy was also assessed using mean pruritus score (MPS) and the mean number of wheals (MNW) score. The most commonly found reactive agents in the specific allergen test were mite DF (18/33 subjects, 54.4%) and mite DP (18/33 subjects, 54.4%). No significant difference was noted before and after levocetirizine monotherapy in terms of CBC, AST, ALT, BUN, creatinine, and ESR. Furthermore, the result of the MAST was also not affected by levocetirizine treatment. Compared to the therapeutic outcome measured on day-8, administration of antihistamine treatment significantly decreased MPS and MNW scores during day-22, day-29, and day-30. Consistently, the mean scores of MPS and MNW were significantly lower on day-36 than on day-8 within the same IgE level. Conclusions: Most of the patients in this study experienced satisfactory clinical improvement after once daily monotherapy with levocetirizine 5mg, whereas the antihistamine treatment did not result in a statistically significant change in the laboratory investigations. This study demonstrates that exhaustive investigations may not be necessary for patients with CIU and should be reserved for individuals following acquisition of a detailed history and physical examination. However, the monotherapy with low-sedative levocetirizine demonstrated a good clinical efficacy and did not significantly alter the laboratory parameters including the result of MAST. Therefore, it is suggested that MAST be included for checking which allergens should be avoided.

KW - Chronic idiopathic urticaria

KW - Laboratory investigation

KW - Levocetirizine

KW - Therapeutic efficacy

UR - http://www.scopus.com/inward/record.url?scp=84869213150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869213150&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84869213150

VL - 32

SP - 233

EP - 238

JO - Journal of Medical Sciences

JF - Journal of Medical Sciences

SN - 1011-4564

IS - 5

ER -