A Structured–Activity Relationship Study of Batracylin Analogues

Yilin Luo, Yun Feng Ren, Ting Chao Chou, Allan Y. Chen, Chiang Yu, Leroy-Fong Liu, C. C. Cheng

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A number of isoindolo[l ,2- b]quinazolines and some benzo[4,5]isoquinolino[l,2- b]quinazolines as structural modification analogues of the antitumor compound batracylin were synthesized and evaluated against HL-60 cell growth and in topoisomerase II-mediated DNA cleavage assays. Of the compounds studied, 10,12-dihydro-7,8-methy lenedioxyisoindolo[ 1,2- b] quinazolin-12(10 H)-one 1d, 2-amino-10,12-dihydroisoindolo[l ,2- b]quinazolin- 12(10 H)-one 1p, and 2-amino-7,8-methylenedioxy-10,12-dihydroisoindolo[l ,2- b]quinazolin-12(10 H)-one 1ab exhibited good inhibitory activities against HL-60 cell lines as well as induction of topo II-mediated DNA cleavage activities.

Original languageEnglish
Pages (from-to)918-923
Number of pages6
JournalPharmaceutical Research
Volume10
Issue number6
DOIs
Publication statusPublished - 1993
Externally publishedYes

Keywords

  • colon adenocarcinoma 38
  • cytotoxicity
  • DNA topoisomerase
  • isoindolo[l,2- b]quinazolines
  • structure–activity relationship

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Organic Chemistry
  • Pharmacology (medical)
  • Pharmaceutical Science
  • Pharmacology
  • Chemistry(all)

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  • Cite this

    Luo, Y., Ren, Y. F., Chou, T. C., Chen, A. Y., Yu, C., Liu, L-F., & Cheng, C. C. (1993). A Structured–Activity Relationship Study of Batracylin Analogues. Pharmaceutical Research, 10(6), 918-923. https://doi.org/10.1023/A:1018929815422