Abstract

An effective method for controlling brain damage and neurodegeneration caused by inflammation remains elusive. Down-expression of the lipopolysaccharide (LPS)-induced inflammatory cytokines resulting in endotoxin tolerance is reported as an alternative anti-infection treatment. Nonetheless, because the dosage and action site are hard to control, endotoxin tolerance caused by low-dose LPS injection in brain tissue may induce side effects. The aim of this study was to test the hypothesis that static magnetic fields (SMF) stimulate endotoxin tolerance in brain tissue. In this study, survival rate and pathological changes in brain tissues of LPS-challenged mice were examined with and without SMF treatment. In addition, the effects of SMF exposure on growth rate and cytokine expression of LPS-challenged BV-2 microglia cells were monitored. Our results showed that SMF pre-exposure had positive effects on the survival rate and histological outcomes of LPS-treated mice. Furthermore, SMF exposure significantly decreased IL-6 expression in BV-2 cells (p

Original languageEnglish
Pages (from-to)132-138
Number of pages7
JournalElectromagnetic Biology and Medicine
Volume33
Issue number2
DOIs
Publication statusPublished - 2014

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Keywords

  • Endotoxin tolerance
  • IL-6
  • Lipopolysaccharide
  • Microglia
  • Neuro-inflammatory
  • Static magnetic field

ASJC Scopus subject areas

  • Biophysics
  • Medicine (miscellaneous)
  • Medicine(all)

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