A solitary congenital self-healing histiocytosis: Report of a case and review of the literature

Shya Wen Shy, Wei Hwa Lee, Yung Ching Chang, Wei Wu

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Congenital self-healing histiocytosis (CSHH), and especially the solitary variant, is a rare primary skin disorder. We report on a newborn with a congenital solitary ulcerated skin nodule. Extracutaneous involvement was not found. A skin biopsy was performed at the age of 44 days and revealed a dense dermal infiltrate of large histiocytic cells. Immunohistochemical study revealed that the cells of the dermal infiltrate were Langerhans' cells which were strongly positive for S-100 and negative for lysozyme, leukocyte common antigen and alpha-1-antichymotrypsin. The skin lesion involuted spontaneously over the next month without any treatment. The clinical, histopathological and immunohistochemical results fulfilled the criteria of solitary CSHH. We herein report the first case of CSHH in Taiwan and the twelfth case of solitary CSHH in the world.

Original languageEnglish
Pages (from-to)869-876
Number of pages8
JournalPathology Research and Practice
Volume192
Issue number8
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Histiocytosis
Skin
alpha 1-Antichymotrypsin
CD45 Antigens
Langerhans Cells
Muramidase
Taiwan
Biopsy

Keywords

  • Congenital self-healing histiocytosis
  • Congenital self-healing reticulohistiocytosis
  • Histiocytosis X
  • Langerhans cell
  • Solitary

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

A solitary congenital self-healing histiocytosis : Report of a case and review of the literature. / Shy, Shya Wen; Lee, Wei Hwa; Chang, Yung Ching; Wu, Wei.

In: Pathology Research and Practice, Vol. 192, No. 8, 1996, p. 869-876.

Research output: Contribution to journalArticle

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