A Simple and Rapid Approach to Hypokalemic Paralysis

Shih Hua Lin, Jainn Shiun Chiu, Chin Wang Hsu, Tom Chau

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Hypokalemia with paralysis (HP) is a potentially reversible medical emergency. It is primarily the result of either hypokalemic periodic paralysis (HPP) caused by an enhanced shift of potassium (K+) into cells or non-HPP resulting from excessive K+ loss. Failure to make a distinction between HPP and non-HPP could lead to improper management. The use of spot urine for K+ excretion rate and evaluation of blood acid-base status could be clinically beneficial in the diagnosis and management. A very low rate of K+ excretion coupled with the absence of a metabolic acid-base disorder suggests HPP, whereas a high rate of K+ excretion accompanied by either metabolic alkalosis or metabolic acidosis favors non-HPP. The therapy of HPP requires only small doses of potassium chloride (KCI) to avoid rebound hyperkalemia. In contrast, higher doses of KCI should be administered to replete the large K+ deficiency in non-HPP.

Original languageEnglish
Pages (from-to)487-491
Number of pages5
JournalAmerican Journal of Emergency Medicine
Volume21
Issue number6
DOIs
Publication statusPublished - Oct 2003
Externally publishedYes

Fingerprint

Hypokalemic Periodic Paralysis
Paralysis
Alkalosis
Hyperkalemia
Acids
Potassium Chloride
Hypokalemia
Acidosis
Potassium
Emergencies
Urine

Keywords

  • Acid-base
  • Hypokalemia
  • Paralysis
  • Potassium excretion rate

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

A Simple and Rapid Approach to Hypokalemic Paralysis. / Lin, Shih Hua; Chiu, Jainn Shiun; Hsu, Chin Wang; Chau, Tom.

In: American Journal of Emergency Medicine, Vol. 21, No. 6, 10.2003, p. 487-491.

Research output: Contribution to journalArticle

Lin, Shih Hua ; Chiu, Jainn Shiun ; Hsu, Chin Wang ; Chau, Tom. / A Simple and Rapid Approach to Hypokalemic Paralysis. In: American Journal of Emergency Medicine. 2003 ; Vol. 21, No. 6. pp. 487-491.
@article{e476dc65a0ff4e52b2f5b256edb70831,
title = "A Simple and Rapid Approach to Hypokalemic Paralysis",
abstract = "Hypokalemia with paralysis (HP) is a potentially reversible medical emergency. It is primarily the result of either hypokalemic periodic paralysis (HPP) caused by an enhanced shift of potassium (K+) into cells or non-HPP resulting from excessive K+ loss. Failure to make a distinction between HPP and non-HPP could lead to improper management. The use of spot urine for K+ excretion rate and evaluation of blood acid-base status could be clinically beneficial in the diagnosis and management. A very low rate of K+ excretion coupled with the absence of a metabolic acid-base disorder suggests HPP, whereas a high rate of K+ excretion accompanied by either metabolic alkalosis or metabolic acidosis favors non-HPP. The therapy of HPP requires only small doses of potassium chloride (KCI) to avoid rebound hyperkalemia. In contrast, higher doses of KCI should be administered to replete the large K+ deficiency in non-HPP.",
keywords = "Acid-base, Hypokalemia, Paralysis, Potassium excretion rate",
author = "Lin, {Shih Hua} and Chiu, {Jainn Shiun} and Hsu, {Chin Wang} and Tom Chau",
year = "2003",
month = "10",
doi = "10.1016/S0735-6757(03)00159-1",
language = "English",
volume = "21",
pages = "487--491",
journal = "American Journal of Emergency Medicine",
issn = "0735-6757",
publisher = "W.B. Saunders",
number = "6",

}

TY - JOUR

T1 - A Simple and Rapid Approach to Hypokalemic Paralysis

AU - Lin, Shih Hua

AU - Chiu, Jainn Shiun

AU - Hsu, Chin Wang

AU - Chau, Tom

PY - 2003/10

Y1 - 2003/10

N2 - Hypokalemia with paralysis (HP) is a potentially reversible medical emergency. It is primarily the result of either hypokalemic periodic paralysis (HPP) caused by an enhanced shift of potassium (K+) into cells or non-HPP resulting from excessive K+ loss. Failure to make a distinction between HPP and non-HPP could lead to improper management. The use of spot urine for K+ excretion rate and evaluation of blood acid-base status could be clinically beneficial in the diagnosis and management. A very low rate of K+ excretion coupled with the absence of a metabolic acid-base disorder suggests HPP, whereas a high rate of K+ excretion accompanied by either metabolic alkalosis or metabolic acidosis favors non-HPP. The therapy of HPP requires only small doses of potassium chloride (KCI) to avoid rebound hyperkalemia. In contrast, higher doses of KCI should be administered to replete the large K+ deficiency in non-HPP.

AB - Hypokalemia with paralysis (HP) is a potentially reversible medical emergency. It is primarily the result of either hypokalemic periodic paralysis (HPP) caused by an enhanced shift of potassium (K+) into cells or non-HPP resulting from excessive K+ loss. Failure to make a distinction between HPP and non-HPP could lead to improper management. The use of spot urine for K+ excretion rate and evaluation of blood acid-base status could be clinically beneficial in the diagnosis and management. A very low rate of K+ excretion coupled with the absence of a metabolic acid-base disorder suggests HPP, whereas a high rate of K+ excretion accompanied by either metabolic alkalosis or metabolic acidosis favors non-HPP. The therapy of HPP requires only small doses of potassium chloride (KCI) to avoid rebound hyperkalemia. In contrast, higher doses of KCI should be administered to replete the large K+ deficiency in non-HPP.

KW - Acid-base

KW - Hypokalemia

KW - Paralysis

KW - Potassium excretion rate

UR - http://www.scopus.com/inward/record.url?scp=0142188783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142188783&partnerID=8YFLogxK

U2 - 10.1016/S0735-6757(03)00159-1

DO - 10.1016/S0735-6757(03)00159-1

M3 - Article

VL - 21

SP - 487

EP - 491

JO - American Journal of Emergency Medicine

JF - American Journal of Emergency Medicine

SN - 0735-6757

IS - 6

ER -