A sialoadenectomy is associated with an increased risk of coronary heart disease: A three-year follow-up study

Shih Han Hung, Chin Hui Su, Herng Ching Lin, Chung Chien Huang, Senyeong Kao

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Abstract

Little is known regarding the long-term adverse effects of a sialoadenectomy. The purpose of this study was to estimate the risk of coronary heart disease (CHD) among patients receiving a sialoadenectomy procedure by utilizing a cohort study based on a population-based database in Taiwan. This study retrieved data of the study sample from the Longitudinal Health Insurance Database 2005. This retrospective cohort study included 608 patients who underwent a sialoadenectomy and 1824 propensity score-matched comparison patients. We individually tracked each sampled patient for a 3-year period from their index date to discriminate those who subsequently received a diagnosis of CHD during the followup period. We found that respective incidence rates of CHD during the 3-year follow-up period were 3.87 (95% confidence interval (CI): 3.01–4.91) and 1.79 (95% CI: 1.45–2.18) per 100 person-years for patients who did and those who did not undergo a sialoadenectomy. The stratified Cox proportional analysis revealed that the hazard ratio of CHD during the 3-year follow-up period was 2.43 (95% CI: 1.77–3.33) than comparison patients. This study demonstrates an association between sialoadenectomy and CHD.

Original languageEnglish
Article numbere0199135
JournalPLoS One
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 1 2018

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Coronary Disease
confidence interval
Confidence Intervals
cohort studies
Health insurance
Cohort Studies
Databases
health insurance
hazard characterization
Propensity Score
risk estimate
Health Insurance
Hazards
Taiwan
Longitudinal Studies
coronary disease
Retrospective Studies
adverse effects
incidence
Incidence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

A sialoadenectomy is associated with an increased risk of coronary heart disease : A three-year follow-up study. / Hung, Shih Han; Su, Chin Hui; Lin, Herng Ching; Huang, Chung Chien; Kao, Senyeong.

In: PLoS One, Vol. 13, No. 6, e0199135, 01.06.2018.

Research output: Contribution to journalArticle

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