A rice bran oil diet improves lipid abnormalities and suppress hyperinsulinemic responses in rats with streptozotocin/nicotinamide-induced type 2 diabetes

Tsui W. Chou, Chien Y. Ma, Hsing Hsien Cheng, Ya Y. Chen, Ming Hoang Lai

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The aim of this study was to determine the effects of rice bran oil (RBO) on lipid metabolism and insulin resistance in rats with streptozotocin/ nicotinamide-induced type 2 diabetes mellitus (T2DM). Rats were divided into two groups: the control group (15% soybean oil, contains 0 g γ-oryzanol and 0 g γ-tocotrienol/150 g oil for 5 weeks) and the RBO group (15% RBO, contains 5.25 g γ-oryzanol and 0.9 g γ-tocotrienol/150 g oil for 5 weeks). Compared with the control group, the RBO group had a lower plasma nonesterified fatty acid concentration, ratio of total to high-density- lipoprotein cholesterol, hepatic cholesterol concentration, and area under the curve for insulin. The RBO group had a higher high-density-lipoprotein cholesterol concentration and greater excretion of fecal neutral sterols and bile acid than did the control group. RBO may improve lipid abnormalities, reduce the atherogenic index, and suppress the hyperinsulinemic response in rats with streptozotocin/nicotinamide-induced T2DM. In addition, RBO can lead to increased fecal neutral sterol and bile acid excretion.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalJournal of Clinical Biochemistry and Nutrition
Volume45
Issue number1
DOIs
Publication statusPublished - Jul 2009

Fingerprint

Niacinamide
Nutrition
Streptozocin
Medical problems
Type 2 Diabetes Mellitus
Rats
Diet
Lipids
Tocotrienols
Sterols
Bile Acids and Salts
Control Groups
HDL Cholesterol
Oils
Insulin
Soybean Oil
rice bran oil
Lipid Metabolism
Nonesterified Fatty Acids
Area Under Curve

Keywords

  • γ-oryzanol
  • γ-tocotrienol
  • Insulin resistance
  • Rice bran oil
  • Type 2 diabetes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

A rice bran oil diet improves lipid abnormalities and suppress hyperinsulinemic responses in rats with streptozotocin/nicotinamide-induced type 2 diabetes. / Chou, Tsui W.; Ma, Chien Y.; Cheng, Hsing Hsien; Chen, Ya Y.; Lai, Ming Hoang.

In: Journal of Clinical Biochemistry and Nutrition, Vol. 45, No. 1, 07.2009, p. 29-36.

Research output: Contribution to journalArticle

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