A Replication Study for Association of ITPKC and CASP3 Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease

Ho-Chang Kuo, Yu-Wen Hsu, Chung-Min Wu, Shawn Hsiang-Yin Chen, Kuo Sheng Hung, Wei-Pin Chang, Kuender D. Yang, Kai-Sheng Hsieh, Wei-Chiao Chen, Yoshihiro Onouchi, Wei Chiao Chang

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Abstract

Single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC, rs28493229) and caspase-3 (CASP3, rs113420705) are associated with susceptibility to KD in Japanese and Taiwanese populations. This study was conducted to investigate the involvement of these 2 SNPs in the risk for intravenous immunoglobulin (IVIG) resistance and coronary artery lesion (CAL) in Taiwanese population. A total of 340 KD patients were subjected to assess by the identification of 2-locus genes model. A combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in CAL formation (P = 0.0227, OR: 3.06). KD patients with high-risk genotype had a trend of overrepresentation in IVIG resistance compared with individual SNPs. Our findings suggest the existence of genetic factors affecting patients' risk for CAL formation and IVIG responsiveness in a Taiwanese population.

Original languageEnglish
Article numbere69685
JournalPLoS One
Volume8
Issue number7
DOIs
Publication statusPublished - Jul 24 2013

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Mucocutaneous Lymph Node Syndrome
Intravenous Immunoglobulins
coronary vessels
Polymorphism
Caspase 3
immunoglobulins
single nucleotide polymorphism
Single Nucleotide Polymorphism
Coronary Vessels
Inositol 1,4,5-trisphosphate 3-kinase
Nucleotides
loci
Population
caspase-3
Identification (control systems)
phosphotransferases (kinases)
Genes
Genotype
genotype
genes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

A Replication Study for Association of ITPKC and CASP3 Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease. / Kuo, Ho-Chang; Hsu, Yu-Wen; Wu, Chung-Min; Chen, Shawn Hsiang-Yin; Hung, Kuo Sheng; Chang, Wei-Pin; Yang, Kuender D.; Hsieh, Kai-Sheng; Chen, Wei-Chiao; Onouchi, Yoshihiro; Chang, Wei Chiao.

In: PLoS One, Vol. 8, No. 7, e69685, 24.07.2013.

Research output: Contribution to journalArticle

Kuo, Ho-Chang ; Hsu, Yu-Wen ; Wu, Chung-Min ; Chen, Shawn Hsiang-Yin ; Hung, Kuo Sheng ; Chang, Wei-Pin ; Yang, Kuender D. ; Hsieh, Kai-Sheng ; Chen, Wei-Chiao ; Onouchi, Yoshihiro ; Chang, Wei Chiao. / A Replication Study for Association of ITPKC and CASP3 Two-Locus Analysis in IVIG Unresponsiveness and Coronary Artery Lesion in Kawasaki Disease. In: PLoS One. 2013 ; Vol. 8, No. 7.
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abstract = "Single-nucleotide polymorphisms (SNPs) in inositol 1,4,5-trisphosphate 3-kinase C (ITPKC, rs28493229) and caspase-3 (CASP3, rs113420705) are associated with susceptibility to KD in Japanese and Taiwanese populations. This study was conducted to investigate the involvement of these 2 SNPs in the risk for intravenous immunoglobulin (IVIG) resistance and coronary artery lesion (CAL) in Taiwanese population. A total of 340 KD patients were subjected to assess by the identification of 2-locus genes model. A combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in CAL formation (P = 0.0227, OR: 3.06). KD patients with high-risk genotype had a trend of overrepresentation in IVIG resistance compared with individual SNPs. Our findings suggest the existence of genetic factors affecting patients' risk for CAL formation and IVIG responsiveness in a Taiwanese population.",
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