A reappraisal of the ovine corticotropin-releasing hormone stimulation test in the differential diagnosis of cushing's syndrome: A comparison with the standard high-dose dexamethasone suppression test

T. I Ting I Lee, Shih Yi Lin, Justin Ging Shing Won, Kam Tsun Tang, Tjin Shing Jap, Ching Fai Kwok, Hong Da Lin

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background. We evaluated the diagnostic efficacy of the ovine corticotropin-releasing hormone (oCRH) stimulation test in the differential diagnosis of Cushing's syndrome and compared it with the standard high-dose dexamethasone suppression test. Methods. Twelve healthy volunteers and 30 with Cushing's syndrome (12 Cushing's disease and 18 adrenal Cushing's syndrome) were enrolled. Plasma ACTH and cortisol levels were measured before and after an intravenous bolus of 100 μg oCRH. Plasma and urinary free cortisol were determined after standard 2-day high-dose dexamethasone suppression. Results. Basal cortisol in 12 patients with Cushing's disease and 18 with adrenal Cushing's syndrome were higher than the control group (21.4 ± 0.1 μg/dl vs. 22.3 ± 0.5 μg/dl vs. 9.1 ± 1.5 μg/dl; p

Original languageEnglish
Pages (from-to)474-482
Number of pages9
JournalChinese Medical Journal (Taipei)
Volume65
Issue number10
Publication statusPublished - Jan 1 2003

Keywords

  • Corticotropin-releasing hormone
  • Cushing's syndrome
  • High-dose dexamethasone

ASJC Scopus subject areas

  • Medicine(all)

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