A prospective study of glucose homeostasis in quetiapine-treated schizophrenic patients by using the intravenous glucose tolerance test

Chun Hsin Chen, Tsang Yaw Lin, Tzu Ting Chen, Vincent Chin Hung Chen, Ni Chi Lin, Wen Chuan Shao, Mong Liang Lu

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12 Citations (Scopus)

Abstract

Increasing attention has been paid recently to the potential diabetogenic effect of second-generation antipsychotics (SGAs). The objective of this prospective study was to evaluate the effects of quetiapine treatment on pancreatic beta-cell function in SGA-naïve schizophrenic patients. Seventeen schizophrenic subjects completed an eight-week trial. The metabolic parameters were assessed at weeks 0, 2, 4, and 8. We measured glucose homeostasis with the intravenous glucose tolerance test. After the eight-week treatment, body weight and body mass index showed to be significantly increased compared to those at baseline. No significant changes were found in serum levels of fasting glucose, insulin, total cholesterol, and high-density lipoprotein. Insulin resistance and insulin secretion were significantly increased. Incidences of clinically significant weight gain and treatment-emergent metabolic syndrome were 11.8% and 11.8%, respectively. This study result confirms the association of quetiapine treatment and impairment of glucose homeostasis in schizophrenic patients.

Original languageEnglish
Pages (from-to)965-969
Number of pages5
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume35
Issue number4
DOIs
Publication statusPublished - Jun 1 2011

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Keywords

  • Insulin resistance
  • Insulin secretion
  • Metabolic syndrome
  • Quetiapine
  • Schizophrenia

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

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