A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor

Tzu Hsuan Wong, Chon Lin Lee, Hsiang Han Su, Chin Lai Lee, Chao Chien Wu, Chin Chou Wang, Chau Chyun Sheu, Ruay Sheng Lai, Sum Yee Leung, Chi Cheng Lin, Yu Feng Wei, Chien Jen Wang, Yu Chun Lin, Hua Ling Chen, Ming Shyan Huang, Jeng Hsien Yen, Shau Ku Huang, Jau Ling Suen

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Chronic exposure to ambient polycyclic aromatic hydrocarbons (PAHs) is associated with asthma, but its regulatory mechanisms remain incompletely defined. We report herein that elevated levels of urinary 1-hydroxypyrene, a biomarker of PAH exposure, were found in asthmatic subjects (n = 39) as compared to those in healthy subjects (n = 43) living in an industrial city of Taiwan, where indeno[1,2,3-cd]pyrene (IP) was found to be a prominent PAH associated with ambient PM2.5. In a mouse model, intranasal exposure of mice with varying doses of IP significantly enhanced antigen-induced allergic inflammation, including increased airway eosinophilia, Th2 cytokines, including IL-4 and IL-5, as well as antigen-specific IgE level, which was absent in dendritic cell (DC)-specific aryl hydrocarbon receptor (AhR)-null mice. Mechanistically, IP treatment significantly altered DC's function, including increased level of pro-inflammatory IL-6 and decreased generation of anti-inflammatory IL-10. The IP's effect was lost in DCs from mice carrying an AhR-mutant allele. Taken together, these results suggest that chronic exposure to environmental PAHs may pose a significant risk for asthma, in which IP, a prominent ambient PAH in Taiwan, was shown to enhance the severity of allergic lung inflammation in mice through, at least in part, its ability in modulating DC's function in an AhR-dependent manner.

Original languageEnglish
Article number5198
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2018
Externally publishedYes

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Aryl Hydrocarbon Receptors
Air Pollutants
Polycyclic Aromatic Hydrocarbons
Pneumonia
Taiwan
Asthma
Antigens
Interleukin-5
Environmental Exposure
Eosinophilia
Interleukin-4
Interleukin-10
Dendritic Cells
Immunoglobulin E
Interleukin-6
Healthy Volunteers
Anti-Inflammatory Agents
Biomarkers
Alleles
indeno(1,2,3-cd)pyrene

ASJC Scopus subject areas

  • General

Cite this

A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor. / Wong, Tzu Hsuan; Lee, Chon Lin; Su, Hsiang Han; Lee, Chin Lai; Wu, Chao Chien; Wang, Chin Chou; Sheu, Chau Chyun; Lai, Ruay Sheng; Leung, Sum Yee; Lin, Chi Cheng; Wei, Yu Feng; Wang, Chien Jen; Lin, Yu Chun; Chen, Hua Ling; Huang, Ming Shyan; Yen, Jeng Hsien; Huang, Shau Ku; Suen, Jau Ling.

In: Scientific Reports, Vol. 8, No. 1, 5198, 01.12.2018.

Research output: Contribution to journalArticle

Wong, TH, Lee, CL, Su, HH, Lee, CL, Wu, CC, Wang, CC, Sheu, CC, Lai, RS, Leung, SY, Lin, CC, Wei, YF, Wang, CJ, Lin, YC, Chen, HL, Huang, MS, Yen, JH, Huang, SK & Suen, JL 2018, 'A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor', Scientific Reports, vol. 8, no. 1, 5198. https://doi.org/10.1038/s41598-018-23542-9
Wong, Tzu Hsuan ; Lee, Chon Lin ; Su, Hsiang Han ; Lee, Chin Lai ; Wu, Chao Chien ; Wang, Chin Chou ; Sheu, Chau Chyun ; Lai, Ruay Sheng ; Leung, Sum Yee ; Lin, Chi Cheng ; Wei, Yu Feng ; Wang, Chien Jen ; Lin, Yu Chun ; Chen, Hua Ling ; Huang, Ming Shyan ; Yen, Jeng Hsien ; Huang, Shau Ku ; Suen, Jau Ling. / A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor. In: Scientific Reports. 2018 ; Vol. 8, No. 1.
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AU - Lee, Chin Lai

AU - Wu, Chao Chien

AU - Wang, Chin Chou

AU - Sheu, Chau Chyun

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AU - Wei, Yu Feng

AU - Wang, Chien Jen

AU - Lin, Yu Chun

AU - Chen, Hua Ling

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