A positive association between homeostasis model assessment of insulin resistance score and the Trp64Arg Polymorphism of the β3-adrenergic receptor gene in schizophrenia patients in Taiwan

Hsien Jane Chiu, Ming Yih Lee, Tzuo Yun Lan, El Wui Loh, Jau Tay Wang, Tsuo Hung Lan

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Abstract

Objective: To investigate the possible association between the Trp64Arg polymorphism of the β3-adrenergic receptor gene and the homeostasis model assessment of insulin resistance (HOMA-IR) index in schizophrenia patients in Taiwan. Method: A total of 203 inpatients who met DSM-IV diagnostic criteria for schizophrenia were recruited from a psychiatry center in Taiwan from September 2002 to August 2003. All patients had been treated with antipsychotics for at least 6 months. The genotyping of the Trp64Arg polymorphism of the β3-adrenergic receptor gene was done by the polymerase chain reaction-restriction fragment length polymorphism method with the restriction enzyme MvaI. The HOMA-IR index was used to indicate the degree of insulin resistance. Results: After adjusting for sex, age, and body mass index status, the association between the HOMA-IR index and the Trp64Arg polymorphism of the β3-adrenergic receptor gene was still positive (regression coefficient = -0.65, P=.033). Conclusions: The polymorphism of the β3-adrenergic receptor gene may be related to the development of insulin resistance in chronic schizophrenia patients in Taiwan.

Original languageEnglish
JournalPrimary Care Companion to the Journal of Clinical Psychiatry
Volume12
Issue number4
DOIs
Publication statusPublished - Dec 30 2010
Externally publishedYes

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Taiwan
Adrenergic Receptors
Insulin Resistance
Schizophrenia
Homeostasis
Genes
Diagnostic and Statistical Manual of Mental Disorders
Restriction Fragment Length Polymorphisms
Antipsychotic Agents
Psychiatry
Inpatients
Body Mass Index
Polymerase Chain Reaction
Enzymes

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

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title = "A positive association between homeostasis model assessment of insulin resistance score and the Trp64Arg Polymorphism of the β3-adrenergic receptor gene in schizophrenia patients in Taiwan",
abstract = "Objective: To investigate the possible association between the Trp64Arg polymorphism of the β3-adrenergic receptor gene and the homeostasis model assessment of insulin resistance (HOMA-IR) index in schizophrenia patients in Taiwan. Method: A total of 203 inpatients who met DSM-IV diagnostic criteria for schizophrenia were recruited from a psychiatry center in Taiwan from September 2002 to August 2003. All patients had been treated with antipsychotics for at least 6 months. The genotyping of the Trp64Arg polymorphism of the β3-adrenergic receptor gene was done by the polymerase chain reaction-restriction fragment length polymorphism method with the restriction enzyme MvaI. The HOMA-IR index was used to indicate the degree of insulin resistance. Results: After adjusting for sex, age, and body mass index status, the association between the HOMA-IR index and the Trp64Arg polymorphism of the β3-adrenergic receptor gene was still positive (regression coefficient = -0.65, P=.033). Conclusions: The polymorphism of the β3-adrenergic receptor gene may be related to the development of insulin resistance in chronic schizophrenia patients in Taiwan.",
author = "Chiu, {Hsien Jane} and Lee, {Ming Yih} and Lan, {Tzuo Yun} and Loh, {El Wui} and Wang, {Jau Tay} and Lan, {Tsuo Hung}",
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AU - Chiu, Hsien Jane

AU - Lee, Ming Yih

AU - Lan, Tzuo Yun

AU - Loh, El Wui

AU - Wang, Jau Tay

AU - Lan, Tsuo Hung

PY - 2010/12/30

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N2 - Objective: To investigate the possible association between the Trp64Arg polymorphism of the β3-adrenergic receptor gene and the homeostasis model assessment of insulin resistance (HOMA-IR) index in schizophrenia patients in Taiwan. Method: A total of 203 inpatients who met DSM-IV diagnostic criteria for schizophrenia were recruited from a psychiatry center in Taiwan from September 2002 to August 2003. All patients had been treated with antipsychotics for at least 6 months. The genotyping of the Trp64Arg polymorphism of the β3-adrenergic receptor gene was done by the polymerase chain reaction-restriction fragment length polymorphism method with the restriction enzyme MvaI. The HOMA-IR index was used to indicate the degree of insulin resistance. Results: After adjusting for sex, age, and body mass index status, the association between the HOMA-IR index and the Trp64Arg polymorphism of the β3-adrenergic receptor gene was still positive (regression coefficient = -0.65, P=.033). Conclusions: The polymorphism of the β3-adrenergic receptor gene may be related to the development of insulin resistance in chronic schizophrenia patients in Taiwan.

AB - Objective: To investigate the possible association between the Trp64Arg polymorphism of the β3-adrenergic receptor gene and the homeostasis model assessment of insulin resistance (HOMA-IR) index in schizophrenia patients in Taiwan. Method: A total of 203 inpatients who met DSM-IV diagnostic criteria for schizophrenia were recruited from a psychiatry center in Taiwan from September 2002 to August 2003. All patients had been treated with antipsychotics for at least 6 months. The genotyping of the Trp64Arg polymorphism of the β3-adrenergic receptor gene was done by the polymerase chain reaction-restriction fragment length polymorphism method with the restriction enzyme MvaI. The HOMA-IR index was used to indicate the degree of insulin resistance. Results: After adjusting for sex, age, and body mass index status, the association between the HOMA-IR index and the Trp64Arg polymorphism of the β3-adrenergic receptor gene was still positive (regression coefficient = -0.65, P=.033). Conclusions: The polymorphism of the β3-adrenergic receptor gene may be related to the development of insulin resistance in chronic schizophrenia patients in Taiwan.

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