A portable micro gas chromatography system for lung cancer associated volatile organic compound detection

Te Hsuen Tzeng, Chun Yen Kuo, San Yuan Wang, Po Kai Huang, Yen Ming Huang, Wei Che Hsieh, Yu Jie Huang, Po Hung Kuo, Shih An Yu, Si Chen Lee, Yufeng Jane Tseng, Wei Cheng Tian, Shey Shi Lu

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

With the help of micro-electromechanical systems (MEMS) and complementary metal-oxide-semiconductor (CMOS) technology, a portable micro gas chromatography (μGC) system for lung cancer associated volatile organic compounds (VOCs) detection is realized for the first time. The system is composed of an MEMS preconcentrator, an MEMS separation column, and a CMOS system-on-chip (SoC). The preconcentrator provides a concentration ratio of 2170. The separation column can separate more than seven types of lung cancer associated VOCs. The SoC is fabricated by a TSMC 0.35 μm 2P4M process including the CMOS VOCs detector, sensor calibration circuit, low-noise chopper instrumentation amplifier (IA), 10 bit analog to digital converter, and the microcontrol unit (MCU). Experimental results show that the system is able to detect seven types of lung cancer associated VOCs (acetone, 2-butanone, benzene, heptane, toluene, m-xylene, 1,3,5-trimethylbenzene). The concentration linearity is R2 = 0.985 and the detection sensitivity is up to 15 ppb with 1,3,5-trimethylbenzene.

Original languageEnglish
Article number7314865
Pages (from-to)259-272
Number of pages14
JournalIEEE Journal of Solid-State Circuits
Volume51
Issue number1
DOIs
Publication statusPublished - Jan 1 2016
Externally publishedYes

Keywords

  • Biomedical
  • Calibration
  • Complementary metal-oxide-semiconductor-micro-electromechanical system (CMOS-MEMS)
  • Continuous wavelet transform (CWT)
  • Deconvolution
  • Micro gas chromatography (μGC )
  • System-on-chip (SoC)
  • Volatile organic compound (VOCS)

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

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  • Cite this

    Tzeng, T. H., Kuo, C. Y., Wang, S. Y., Huang, P. K., Huang, Y. M., Hsieh, W. C., Huang, Y. J., Kuo, P. H., Yu, S. A., Lee, S. C., Tseng, Y. J., Tian, W. C., & Lu, S. S. (2016). A portable micro gas chromatography system for lung cancer associated volatile organic compound detection. IEEE Journal of Solid-State Circuits, 51(1), 259-272. [7314865]. https://doi.org/10.1109/JSSC.2015.2489839