A population-based study on the association between urinary calculi and kidney cancer

Shiu Dong Chung, Shih Ping Liu, Herng Ching Lin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Using a nationwide population-based dataset and case-control study design, we investigate the association between urinary calculi (UC) and kidney cancer (KC) in Taiwan. Methods: The data for this case-control study were sourced from the Taiwan National Health Insurance program. The cases included 1308 incident patients pathologically diagnosed with KC. This study also used 6540 randomly selected subjects as controls. Conditional logistic regression was used to examine the associations between KC and patients previously diagnosed with UC. Results: Of the sampled patients, 1262 (16.1 %) had previously been diagnosed with UC; 415 (31.7 % of the patients with KC) and 847 controls (13.0 % of patients without KC). After adjusting for monthly income, geographic location, urbanization level, hypertension, diabetes, renal disease, obesity, cystic kidney disease, tobacco use disorder, and alcohol abuse, we found that patients with KC were likely to have been previously diagnosed with UC than controls (odds ratio [OR] 3.18, 95% confidence interval [CI] 2.75-3.68, p <0.001). In addition, the magnitude of the observed associations were stronger among females (females OR 3.59; 95% CI 2.87-4.48 vs. males OR 2.93, 95% CI 2.42-3.55) and transitional cell carcinoma patients (transitional cell carcinoma, OR 3.96; 95% CI 3.23-4.86 vs. renal cell carcinoma OR 2.76, 95% CI 2.31-3.29). Conclusions: We conclude that there is an association between KC and prior UC, especially in females and patients with transitional cell carcinoma.

Original languageEnglish
JournalJournal of the Canadian Urological Association
Volume7
Issue number11-12
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Urinary Calculi
Kidney Neoplasms
Odds Ratio
Population
Confidence Intervals
Transitional Cell Carcinoma
National Health Programs
Taiwan
Case-Control Studies
Cystic Kidney Diseases
Geographic Locations
Tobacco Use Disorder
Urbanization
Renal Hypertension
Renal Cell Carcinoma
Alcoholism
Obesity
Logistic Models

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

A population-based study on the association between urinary calculi and kidney cancer. / Chung, Shiu Dong; Liu, Shih Ping; Lin, Herng Ching.

In: Journal of the Canadian Urological Association, Vol. 7, No. 11-12, 11.2013.

Research output: Contribution to journalArticle

@article{10fd2a3d90ab43b492a6d2285a81c95b,
title = "A population-based study on the association between urinary calculi and kidney cancer",
abstract = "Background: Using a nationwide population-based dataset and case-control study design, we investigate the association between urinary calculi (UC) and kidney cancer (KC) in Taiwan. Methods: The data for this case-control study were sourced from the Taiwan National Health Insurance program. The cases included 1308 incident patients pathologically diagnosed with KC. This study also used 6540 randomly selected subjects as controls. Conditional logistic regression was used to examine the associations between KC and patients previously diagnosed with UC. Results: Of the sampled patients, 1262 (16.1 {\%}) had previously been diagnosed with UC; 415 (31.7 {\%} of the patients with KC) and 847 controls (13.0 {\%} of patients without KC). After adjusting for monthly income, geographic location, urbanization level, hypertension, diabetes, renal disease, obesity, cystic kidney disease, tobacco use disorder, and alcohol abuse, we found that patients with KC were likely to have been previously diagnosed with UC than controls (odds ratio [OR] 3.18, 95{\%} confidence interval [CI] 2.75-3.68, p <0.001). In addition, the magnitude of the observed associations were stronger among females (females OR 3.59; 95{\%} CI 2.87-4.48 vs. males OR 2.93, 95{\%} CI 2.42-3.55) and transitional cell carcinoma patients (transitional cell carcinoma, OR 3.96; 95{\%} CI 3.23-4.86 vs. renal cell carcinoma OR 2.76, 95{\%} CI 2.31-3.29). Conclusions: We conclude that there is an association between KC and prior UC, especially in females and patients with transitional cell carcinoma.",
author = "Chung, {Shiu Dong} and Liu, {Shih Ping} and Lin, {Herng Ching}",
year = "2013",
month = "11",
doi = "10.5489/cuaj.366",
language = "English",
volume = "7",
journal = "Journal of the Canadian Urological Association",
issn = "1911-6470",
publisher = "Canadian Medical Association",
number = "11-12",

}

TY - JOUR

T1 - A population-based study on the association between urinary calculi and kidney cancer

AU - Chung, Shiu Dong

AU - Liu, Shih Ping

AU - Lin, Herng Ching

PY - 2013/11

Y1 - 2013/11

N2 - Background: Using a nationwide population-based dataset and case-control study design, we investigate the association between urinary calculi (UC) and kidney cancer (KC) in Taiwan. Methods: The data for this case-control study were sourced from the Taiwan National Health Insurance program. The cases included 1308 incident patients pathologically diagnosed with KC. This study also used 6540 randomly selected subjects as controls. Conditional logistic regression was used to examine the associations between KC and patients previously diagnosed with UC. Results: Of the sampled patients, 1262 (16.1 %) had previously been diagnosed with UC; 415 (31.7 % of the patients with KC) and 847 controls (13.0 % of patients without KC). After adjusting for monthly income, geographic location, urbanization level, hypertension, diabetes, renal disease, obesity, cystic kidney disease, tobacco use disorder, and alcohol abuse, we found that patients with KC were likely to have been previously diagnosed with UC than controls (odds ratio [OR] 3.18, 95% confidence interval [CI] 2.75-3.68, p <0.001). In addition, the magnitude of the observed associations were stronger among females (females OR 3.59; 95% CI 2.87-4.48 vs. males OR 2.93, 95% CI 2.42-3.55) and transitional cell carcinoma patients (transitional cell carcinoma, OR 3.96; 95% CI 3.23-4.86 vs. renal cell carcinoma OR 2.76, 95% CI 2.31-3.29). Conclusions: We conclude that there is an association between KC and prior UC, especially in females and patients with transitional cell carcinoma.

AB - Background: Using a nationwide population-based dataset and case-control study design, we investigate the association between urinary calculi (UC) and kidney cancer (KC) in Taiwan. Methods: The data for this case-control study were sourced from the Taiwan National Health Insurance program. The cases included 1308 incident patients pathologically diagnosed with KC. This study also used 6540 randomly selected subjects as controls. Conditional logistic regression was used to examine the associations between KC and patients previously diagnosed with UC. Results: Of the sampled patients, 1262 (16.1 %) had previously been diagnosed with UC; 415 (31.7 % of the patients with KC) and 847 controls (13.0 % of patients without KC). After adjusting for monthly income, geographic location, urbanization level, hypertension, diabetes, renal disease, obesity, cystic kidney disease, tobacco use disorder, and alcohol abuse, we found that patients with KC were likely to have been previously diagnosed with UC than controls (odds ratio [OR] 3.18, 95% confidence interval [CI] 2.75-3.68, p <0.001). In addition, the magnitude of the observed associations were stronger among females (females OR 3.59; 95% CI 2.87-4.48 vs. males OR 2.93, 95% CI 2.42-3.55) and transitional cell carcinoma patients (transitional cell carcinoma, OR 3.96; 95% CI 3.23-4.86 vs. renal cell carcinoma OR 2.76, 95% CI 2.31-3.29). Conclusions: We conclude that there is an association between KC and prior UC, especially in females and patients with transitional cell carcinoma.

UR - http://www.scopus.com/inward/record.url?scp=84887344865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887344865&partnerID=8YFLogxK

U2 - 10.5489/cuaj.366

DO - 10.5489/cuaj.366

M3 - Article

AN - SCOPUS:84887344865

VL - 7

JO - Journal of the Canadian Urological Association

JF - Journal of the Canadian Urological Association

SN - 1911-6470

IS - 11-12

ER -