A population-based study on the association between statin use and sudden sensorineural hearing loss

Shiu Dong Chung, Chao Hung Chen, Shih Han Hung, Herng Ching Lin, Li Hsuan Wang

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives. No study has reported the relationship between statin use and sudden sensorineural hearing loss (SSNHL). In this study, we examined the association between statin use and SSNHL using a population-based dataset. Study Design. A case-control study. Setting. Taiwan. Subjects and Methods. The study sample was selected from the Taiwan Longitudinal Health Insurance Database. We identified 1263 subjects aged ≥40 years with SSNHL and 6315 sex-, age-, hypertension-, and coronary heart diseasematched controls. We used conditional logistic regression to compute the odds ratio (OR) for having been a previous statin user between cases and controls. Furthermore, we performed conditional logistic regression to explore the relationship of regular and irregular statin users with SSNHL. Results. There was a significant difference in the prevalence of statin use between cases and controls (27.2% vs 21.3%, respectively; P <.001). The OR of statin use before the index date for cases was 1.36 (95% confidence interval [CI], 1.18-1.57) compared to controls after taking gender, age group, hypertension, coronary heart disease, diabetes, renal disease, and hyperlipidemia into consideration. Furthermore, compared to controls, the adjusted ORs of regular and irregular statin use for cases were 1.30 (95% CI, 1.11-1.52) and 1.49 (95% CI, 1.11-1.93), respectively, compared to controls. Conclusion. This study found that SSNHL was significantly associated with previous statin use.

Original languageEnglish
Pages (from-to)319-325
Number of pages7
JournalOtolaryngology - Head and Neck Surgery
Volume152
Issue number2
DOIs
Publication statusPublished - Feb 5 2015

Fingerprint

Sudden Hearing Loss
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Sensorineural Hearing Loss
Population
Confidence Intervals
Taiwan
Logistic Models
Odds Ratio
Hypertension
Health Insurance
Hyperlipidemias
Coronary Disease
Case-Control Studies
Age Groups
Databases
Kidney

Keywords

  • hearing loss
  • statin
  • sudden hearing loss

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery
  • Medicine(all)

Cite this

A population-based study on the association between statin use and sudden sensorineural hearing loss. / Chung, Shiu Dong; Chen, Chao Hung; Hung, Shih Han; Lin, Herng Ching; Wang, Li Hsuan.

In: Otolaryngology - Head and Neck Surgery, Vol. 152, No. 2, 05.02.2015, p. 319-325.

Research output: Contribution to journalArticle

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