A population-based study of the association between areca nut chewing and Type 2 diabetes mellitus in men (Keelung Community-based Integrated Screening programme No. 2)

T. H. Tung, Y. H. Chiu, L. S. Chen, H. M. Wu, B. J. Boucher, T. H H Chen

Research output: Contribution to journalArticle

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Abstract

Aims/hypothesis. The aim of this study was to assess whether the diabetogenicity of areca nut (Areca catechu or 'betel-nut'), which has previously been demonstrated experimentally in mice, independently contributes to the risk of hyperglycaemia or Type 2 diabetes in men in Taiwan, where the habit has become established relatively recently. Methods. We used data from a population-based cross-sectional survey and a multiple-disease-screening programme that tested for hyperglycaemia, Type 2 diabetes and risk factors related to Type 2 diabetes. Data on habitual areca nut chewing were available for 14,816 men. Multiple logistic regression models were used to determine whether areca nut chewing was an independent risk factor for Type 2 diabetes. Results. Compared with non-chewers, areca nut chewers had higher age-adjusted prevalence rates for hyperglycaemia (11.4% vs 8.7%) and Type 2 diabetes (10.3% vs 7.8%). Areca nut chewing independently increased the risk of hyperglycaemia (adjusted odds ratio [OR] 1.19, 95% CI 0.97-1.45) and Type 2 diabetes (adjusted OR 1.29, 95% CI 1.04-1.60). The independent effects of duration of chewing were dose-dependent for Type 2 diabetes (adjusted OR 1.32 for the duration of 10-19 years and 1.41 for the duration of ≥20 years), as were the effects of increased rates of areca nut chewing (adjusted OR 1.14 for

Original languageEnglish
Pages (from-to)1776-1781
Number of pages6
JournalDiabetologia
Volume47
Issue number10
DOIs
Publication statusPublished - Oct 2004
Externally publishedYes

Fingerprint

Areca
Nuts
Mastication
Type 2 Diabetes Mellitus
Hyperglycemia
Population
Odds Ratio
Logistic Models
Taiwan
Habits
Cross-Sectional Studies

Keywords

  • Areca nut
  • Betel
  • Hyperglycaemia
  • Type 2 diabetes

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

A population-based study of the association between areca nut chewing and Type 2 diabetes mellitus in men (Keelung Community-based Integrated Screening programme No. 2). / Tung, T. H.; Chiu, Y. H.; Chen, L. S.; Wu, H. M.; Boucher, B. J.; Chen, T. H H.

In: Diabetologia, Vol. 47, No. 10, 10.2004, p. 1776-1781.

Research output: Contribution to journalArticle

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abstract = "Aims/hypothesis. The aim of this study was to assess whether the diabetogenicity of areca nut (Areca catechu or 'betel-nut'), which has previously been demonstrated experimentally in mice, independently contributes to the risk of hyperglycaemia or Type 2 diabetes in men in Taiwan, where the habit has become established relatively recently. Methods. We used data from a population-based cross-sectional survey and a multiple-disease-screening programme that tested for hyperglycaemia, Type 2 diabetes and risk factors related to Type 2 diabetes. Data on habitual areca nut chewing were available for 14,816 men. Multiple logistic regression models were used to determine whether areca nut chewing was an independent risk factor for Type 2 diabetes. Results. Compared with non-chewers, areca nut chewers had higher age-adjusted prevalence rates for hyperglycaemia (11.4{\%} vs 8.7{\%}) and Type 2 diabetes (10.3{\%} vs 7.8{\%}). Areca nut chewing independently increased the risk of hyperglycaemia (adjusted odds ratio [OR] 1.19, 95{\%} CI 0.97-1.45) and Type 2 diabetes (adjusted OR 1.29, 95{\%} CI 1.04-1.60). The independent effects of duration of chewing were dose-dependent for Type 2 diabetes (adjusted OR 1.32 for the duration of 10-19 years and 1.41 for the duration of ≥20 years), as were the effects of increased rates of areca nut chewing (adjusted OR 1.14 for",
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