A population-based cohort study suggests an increased risk of multiple sclerosis incidence in patients with type 2 diabetes mellitus

Wen Hsuan Hou, Chung Yi Li, Hsin-Hui Chang, Yu Sun, Chiang Chin Tsai

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: To prospectively investigate the incidence and relative risks of multiple sclerosis (MS) in patients with type 2 diabetes (T2DM). Materials and methods: Patients with T2DM (n = 614,623) and age- and sex-matched controls (n = 614,021) were followed from 2000 to 2008 to identify cases of newly diagnosed MS (ICD-9-CM: 340). The person-year approach with Poisson assumption was used to evaluate the incidence density. We estimated the covariate-adjusted hazard ratio (HR) of MS incidence in relation to T2DM diabetes using a multiple Cox proportional hazard regression model. Results: Over 9 years of follow-up, 175 T2DM patients were newly diagnosed with MS, and 114 matched controls had the same first-ever diagnosis, representing a covariate-adjusted HR of 1.44 (95% confidence interval [CI], 1.08-1.94). The sex-specific adjusted HR for both men and women with T2DM was also elevated at 1.34 (95% CI, 0.81-2.23) and 1.51 (95% CI, 1.05-2.19), respectively. Women aged <50 years had the greatest risk of MS (HR 2.16; 95% CI, 1.02-4.59). Conclusion: This study demonstrated a moderate but significant association of T2DM with MS incidence, and the association was not confounded by socio-demographic characteristics or certain MS-related comorbidities.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalJournal of Epidemiology
Volume27
Issue number5
DOIs
Publication statusPublished - 2017

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Type 2 Diabetes Mellitus
Multiple Sclerosis
Cohort Studies
Incidence
Population
Confidence Intervals
International Classification of Diseases
Proportional Hazards Models
Comorbidity
Demography

Keywords

  • Cohort studies
  • Cox proportional hazard model
  • Diabetes mellitus
  • Multiple sclerosis

ASJC Scopus subject areas

  • Epidemiology

Cite this

A population-based cohort study suggests an increased risk of multiple sclerosis incidence in patients with type 2 diabetes mellitus. / Hou, Wen Hsuan; Li, Chung Yi; Chang, Hsin-Hui ; Sun, Yu; Tsai, Chiang Chin.

In: Journal of Epidemiology, Vol. 27, No. 5, 2017, p. 235-241.

Research output: Contribution to journalArticle

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abstract = "Background: To prospectively investigate the incidence and relative risks of multiple sclerosis (MS) in patients with type 2 diabetes (T2DM). Materials and methods: Patients with T2DM (n = 614,623) and age- and sex-matched controls (n = 614,021) were followed from 2000 to 2008 to identify cases of newly diagnosed MS (ICD-9-CM: 340). The person-year approach with Poisson assumption was used to evaluate the incidence density. We estimated the covariate-adjusted hazard ratio (HR) of MS incidence in relation to T2DM diabetes using a multiple Cox proportional hazard regression model. Results: Over 9 years of follow-up, 175 T2DM patients were newly diagnosed with MS, and 114 matched controls had the same first-ever diagnosis, representing a covariate-adjusted HR of 1.44 (95{\%} confidence interval [CI], 1.08-1.94). The sex-specific adjusted HR for both men and women with T2DM was also elevated at 1.34 (95{\%} CI, 0.81-2.23) and 1.51 (95{\%} CI, 1.05-2.19), respectively. Women aged <50 years had the greatest risk of MS (HR 2.16; 95{\%} CI, 1.02-4.59). Conclusion: This study demonstrated a moderate but significant association of T2DM with MS incidence, and the association was not confounded by socio-demographic characteristics or certain MS-related comorbidities.",
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T1 - A population-based cohort study suggests an increased risk of multiple sclerosis incidence in patients with type 2 diabetes mellitus

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AU - Li, Chung Yi

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AU - Sun, Yu

AU - Tsai, Chiang Chin

PY - 2017

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N2 - Background: To prospectively investigate the incidence and relative risks of multiple sclerosis (MS) in patients with type 2 diabetes (T2DM). Materials and methods: Patients with T2DM (n = 614,623) and age- and sex-matched controls (n = 614,021) were followed from 2000 to 2008 to identify cases of newly diagnosed MS (ICD-9-CM: 340). The person-year approach with Poisson assumption was used to evaluate the incidence density. We estimated the covariate-adjusted hazard ratio (HR) of MS incidence in relation to T2DM diabetes using a multiple Cox proportional hazard regression model. Results: Over 9 years of follow-up, 175 T2DM patients were newly diagnosed with MS, and 114 matched controls had the same first-ever diagnosis, representing a covariate-adjusted HR of 1.44 (95% confidence interval [CI], 1.08-1.94). The sex-specific adjusted HR for both men and women with T2DM was also elevated at 1.34 (95% CI, 0.81-2.23) and 1.51 (95% CI, 1.05-2.19), respectively. Women aged <50 years had the greatest risk of MS (HR 2.16; 95% CI, 1.02-4.59). Conclusion: This study demonstrated a moderate but significant association of T2DM with MS incidence, and the association was not confounded by socio-demographic characteristics or certain MS-related comorbidities.

AB - Background: To prospectively investigate the incidence and relative risks of multiple sclerosis (MS) in patients with type 2 diabetes (T2DM). Materials and methods: Patients with T2DM (n = 614,623) and age- and sex-matched controls (n = 614,021) were followed from 2000 to 2008 to identify cases of newly diagnosed MS (ICD-9-CM: 340). The person-year approach with Poisson assumption was used to evaluate the incidence density. We estimated the covariate-adjusted hazard ratio (HR) of MS incidence in relation to T2DM diabetes using a multiple Cox proportional hazard regression model. Results: Over 9 years of follow-up, 175 T2DM patients were newly diagnosed with MS, and 114 matched controls had the same first-ever diagnosis, representing a covariate-adjusted HR of 1.44 (95% confidence interval [CI], 1.08-1.94). The sex-specific adjusted HR for both men and women with T2DM was also elevated at 1.34 (95% CI, 0.81-2.23) and 1.51 (95% CI, 1.05-2.19), respectively. Women aged <50 years had the greatest risk of MS (HR 2.16; 95% CI, 1.02-4.59). Conclusion: This study demonstrated a moderate but significant association of T2DM with MS incidence, and the association was not confounded by socio-demographic characteristics or certain MS-related comorbidities.

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