Abstract

Objective: Chronic inflammation has been associated with endothelial dysfunction and altered coagulation status. However, at the present time, the data regarding the risk for developing deep vein thrombosis (DVT) in patients with rheumatoid arthritis (RA) is still scanty and conflicted. This study aimed to explore the frequency and association of DVT with RA using a population-based dataset. Methods: This was a case-control study conducted in Taiwan. A total of 5193 patients with DVT were identified from the Longitudinal Health Insurance Database 2000 (LHID2000) database. In total, 20,772 controls matched with cases in terms of gender, age, and year of index date were randomly selected. We used conditional logistic regression to calculate the odds ratio (OR) for having been previously diagnosed with RA between cases and controls. Results: Of the total 25,965 sampled subjects, 235 (0.9%) had been previously diagnosed with RA. Seventy-seven of these previous diagnoses were found among cases (1.5%) and 158 among controls (0.8%). Conditional logistic regression analysis revealed that cases were more likely to have had prior RA than controls (OR, 1.92; 95% confidence interval [CI], 1.46-2.53; P

Original languageEnglish
Pages (from-to)1642-1648
Number of pages7
JournalJournal of Vascular Surgery
Volume56
Issue number6
DOIs
Publication statusPublished - Dec 2012

Fingerprint

Venous Thrombosis
Case-Control Studies
Rheumatoid Arthritis
Population
Logistic Models
Odds Ratio
Databases
Health Insurance
Taiwan
Regression Analysis
Confidence Intervals
Inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

@article{fef93753e655459cb1acc567e49ed55e,
title = "A population-based case-control study on the association between rheumatoid arthritis and deep vein thrombosis",
abstract = "Objective: Chronic inflammation has been associated with endothelial dysfunction and altered coagulation status. However, at the present time, the data regarding the risk for developing deep vein thrombosis (DVT) in patients with rheumatoid arthritis (RA) is still scanty and conflicted. This study aimed to explore the frequency and association of DVT with RA using a population-based dataset. Methods: This was a case-control study conducted in Taiwan. A total of 5193 patients with DVT were identified from the Longitudinal Health Insurance Database 2000 (LHID2000) database. In total, 20,772 controls matched with cases in terms of gender, age, and year of index date were randomly selected. We used conditional logistic regression to calculate the odds ratio (OR) for having been previously diagnosed with RA between cases and controls. Results: Of the total 25,965 sampled subjects, 235 (0.9{\%}) had been previously diagnosed with RA. Seventy-seven of these previous diagnoses were found among cases (1.5{\%}) and 158 among controls (0.8{\%}). Conditional logistic regression analysis revealed that cases were more likely to have had prior RA than controls (OR, 1.92; 95{\%} confidence interval [CI], 1.46-2.53; P",
author = "Kang, {Jiunn Horng} and Keller, {Joseph J.} and Yen-Kuang Lin and Lin, {Herng Ching}",
year = "2012",
month = "12",
doi = "10.1016/j.jvs.2012.05.087",
language = "English",
volume = "56",
pages = "1642--1648",
journal = "Journal of Vascular Surgery",
issn = "0741-5214",
publisher = "Mosby Inc.",
number = "6",

}

TY - JOUR

T1 - A population-based case-control study on the association between rheumatoid arthritis and deep vein thrombosis

AU - Kang, Jiunn Horng

AU - Keller, Joseph J.

AU - Lin, Yen-Kuang

AU - Lin, Herng Ching

PY - 2012/12

Y1 - 2012/12

N2 - Objective: Chronic inflammation has been associated with endothelial dysfunction and altered coagulation status. However, at the present time, the data regarding the risk for developing deep vein thrombosis (DVT) in patients with rheumatoid arthritis (RA) is still scanty and conflicted. This study aimed to explore the frequency and association of DVT with RA using a population-based dataset. Methods: This was a case-control study conducted in Taiwan. A total of 5193 patients with DVT were identified from the Longitudinal Health Insurance Database 2000 (LHID2000) database. In total, 20,772 controls matched with cases in terms of gender, age, and year of index date were randomly selected. We used conditional logistic regression to calculate the odds ratio (OR) for having been previously diagnosed with RA between cases and controls. Results: Of the total 25,965 sampled subjects, 235 (0.9%) had been previously diagnosed with RA. Seventy-seven of these previous diagnoses were found among cases (1.5%) and 158 among controls (0.8%). Conditional logistic regression analysis revealed that cases were more likely to have had prior RA than controls (OR, 1.92; 95% confidence interval [CI], 1.46-2.53; P

AB - Objective: Chronic inflammation has been associated with endothelial dysfunction and altered coagulation status. However, at the present time, the data regarding the risk for developing deep vein thrombosis (DVT) in patients with rheumatoid arthritis (RA) is still scanty and conflicted. This study aimed to explore the frequency and association of DVT with RA using a population-based dataset. Methods: This was a case-control study conducted in Taiwan. A total of 5193 patients with DVT were identified from the Longitudinal Health Insurance Database 2000 (LHID2000) database. In total, 20,772 controls matched with cases in terms of gender, age, and year of index date were randomly selected. We used conditional logistic regression to calculate the odds ratio (OR) for having been previously diagnosed with RA between cases and controls. Results: Of the total 25,965 sampled subjects, 235 (0.9%) had been previously diagnosed with RA. Seventy-seven of these previous diagnoses were found among cases (1.5%) and 158 among controls (0.8%). Conditional logistic regression analysis revealed that cases were more likely to have had prior RA than controls (OR, 1.92; 95% confidence interval [CI], 1.46-2.53; P

UR - http://www.scopus.com/inward/record.url?scp=84870251917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870251917&partnerID=8YFLogxK

U2 - 10.1016/j.jvs.2012.05.087

DO - 10.1016/j.jvs.2012.05.087

M3 - Article

C2 - 23085092

AN - SCOPUS:84870251917

VL - 56

SP - 1642

EP - 1648

JO - Journal of Vascular Surgery

JF - Journal of Vascular Surgery

SN - 0741-5214

IS - 6

ER -