A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis

Jeng Hsien Yen; Che Mai Chang; Yu Wen Hsu; Chih Hung Lee; Mei Shin Wu; Daw Yang Hwang; Ben Kuen Chen; Hsien Tzung Liao; Man Tzu Marcie Wu; Wei Chiao Chang

doi:10.1155/2014/834831

A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis

Jeng Hsien Yen, Che Mai Chang, Yu Wen Hsu, Chih Hung Lee, Mei Shin Wu, Daw Yang Hwang, Ben Kuen Chen, Hsien Tzung Liao, Man Tzu Marcie Wu, Wei Chiao Chang

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19 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.

Original language	English
Article number	834831
Journal	Mediators of Inflammation
Volume	2014
DOIs	https://doi.org/10.1155/2014/834831
Publication status	Published - 2014

ASJC Scopus subject areas

Immunology
Cell Biology

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title = "A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis",

abstract = "Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.",

author = "Yen, {Jeng Hsien} and Chang, {Che Mai} and Hsu, {Yu Wen} and Lee, {Chih Hung} and Wu, {Mei Shin} and Hwang, {Daw Yang} and Chen, {Ben Kuen} and Liao, {Hsien Tzung} and Wu, {Man Tzu Marcie} and Chang, {Wei Chiao}",

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doi = "10.1155/2014/834831",

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T1 - A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis

AU - Yen, Jeng Hsien

AU - Chang, Che Mai

AU - Hsu, Yu Wen

AU - Lee, Chih Hung

AU - Wu, Mei Shin

AU - Hwang, Daw Yang

AU - Chen, Ben Kuen

AU - Liao, Hsien Tzung

AU - Wu, Man Tzu Marcie

AU - Chang, Wei Chiao

PY - 2014

Y1 - 2014

N2 - Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.

AB - Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.

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A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis

Abstract

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