Abstract
Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.
| Original language | English |
|---|---|
| Article number | 834831 |
| Journal | Mediators of Inflammation |
| Volume | 2014 |
| DOIs | |
| Publication status | Published - 2014 |
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ASJC Scopus subject areas
- Immunology
- Cell Biology
- Medicine(all)
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A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis. / Yen, Jeng Hsien; Chang, Che Mai; Hsu, Yu Wen; Lee, Chih Hung; Wu, Mei Shin; Hwang, Daw Yang; Chen, Ben Kuen; Liao, Hsien Tzung; Wu, Man Tzu Marcie; Chang, Wei Chiao.
In: Mediators of Inflammation, Vol. 2014, 834831, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis
AU - Yen, Jeng Hsien
AU - Chang, Che Mai
AU - Hsu, Yu Wen
AU - Lee, Chih Hung
AU - Wu, Mei Shin
AU - Hwang, Daw Yang
AU - Chen, Ben Kuen
AU - Liao, Hsien Tzung
AU - Wu, Man Tzu Marcie
AU - Chang, Wei Chiao
PY - 2014
Y1 - 2014
N2 - Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.
AB - Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.
UR - http://www.scopus.com/inward/record.url?scp=84899964717&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899964717&partnerID=8YFLogxK
U2 - 10.1155/2014/834831
DO - 10.1155/2014/834831
M3 - Article
VL - 2014
JO - Mediators of Inflammation
JF - Mediators of Inflammation
SN - 0962-9351
M1 - 834831
ER -