A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis

Jeng Hsien Yen, Che Mai Chang, Yu Wen Hsu, Chih Hung Lee, Mei Shin Wu, Daw Yang Hwang, Ben Kuen Chen, Hsien Tzung Liao, Man Tzu Marcie Wu, Wei Chiao Chang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.

Original languageEnglish
Article number834831
JournalMediators of Inflammation
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Rheumatoid Arthritis
Genes
Single Nucleotide Polymorphism
Chronic Disease
Immune System Diseases
Genetic Association Studies
Genetic Polymorphisms
Immune System
Joints
Population

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Medicine(all)

Cite this

A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis. / Yen, Jeng Hsien; Chang, Che Mai; Hsu, Yu Wen; Lee, Chih Hung; Wu, Mei Shin; Hwang, Daw Yang; Chen, Ben Kuen; Liao, Hsien Tzung; Wu, Man Tzu Marcie; Chang, Wei Chiao.

In: Mediators of Inflammation, Vol. 2014, 834831, 2014.

Research output: Contribution to journalArticle

Yen, JH, Chang, CM, Hsu, YW, Lee, CH, Wu, MS, Hwang, DY, Chen, BK, Liao, HT, Wu, MTM & Chang, WC 2014, 'A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis', Mediators of Inflammation, vol. 2014, 834831. https://doi.org/10.1155/2014/834831
Yen, Jeng Hsien ; Chang, Che Mai ; Hsu, Yu Wen ; Lee, Chih Hung ; Wu, Mei Shin ; Hwang, Daw Yang ; Chen, Ben Kuen ; Liao, Hsien Tzung ; Wu, Man Tzu Marcie ; Chang, Wei Chiao. / A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis. In: Mediators of Inflammation. 2014 ; Vol. 2014.
@article{645143fd6c494c5eae9a7169ed78dec7,
title = "A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis",
abstract = "Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.",
author = "Yen, {Jeng Hsien} and Chang, {Che Mai} and Hsu, {Yu Wen} and Lee, {Chih Hung} and Wu, {Mei Shin} and Hwang, {Daw Yang} and Chen, {Ben Kuen} and Liao, {Hsien Tzung} and Wu, {Man Tzu Marcie} and Chang, {Wei Chiao}",
year = "2014",
doi = "10.1155/2014/834831",
language = "English",
volume = "2014",
journal = "Mediators of Inflammation",
issn = "0962-9351",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis

AU - Yen, Jeng Hsien

AU - Chang, Che Mai

AU - Hsu, Yu Wen

AU - Lee, Chih Hung

AU - Wu, Mei Shin

AU - Hwang, Daw Yang

AU - Chen, Ben Kuen

AU - Liao, Hsien Tzung

AU - Wu, Man Tzu Marcie

AU - Chang, Wei Chiao

PY - 2014

Y1 - 2014

N2 - Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.

AB - Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.

UR - http://www.scopus.com/inward/record.url?scp=84899964717&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899964717&partnerID=8YFLogxK

U2 - 10.1155/2014/834831

DO - 10.1155/2014/834831

M3 - Article

VL - 2014

JO - Mediators of Inflammation

JF - Mediators of Inflammation

SN - 0962-9351

M1 - 834831

ER -