Abstract

Background: Patients with polycystic ovary syndrome (PCOS) have a higher apnea-hypopnea index (AHI) than did controls. The relationship between heart rate variability (HRV) changes and apneic-hypopneic events in non-obese women with PCOS during sleep is yet to be determined. Methods: All participants (14 untreated women with PCOS and 11 age- and BMI-controlled healthy women, with mean body mass indexes of 21.51 ± 0.63 and 21.27 ± 0.66 Kg/cm 2, respectively) underwent whole-night standard polysomnographic (PSG) monitoring and assessment of serum hormone and homeostasis model assessment of insulin resistance (HOMA-IR). Short-term HRV (in different sleep stages) and long-term HRV (6-hour sleep) were obtained by a power spectral analys is. Results: The AHI and arousal index during the non-rapid eye movement stage (AHI NREM and ARI NREM) were both higher in non-obese women with PCOS than those in the control group (0.032 ± 0.028 vs. 0.698 ± 0.243 p = 0.004; 11.45 ± 0.864 vs. 8.636 ± 0.847 p = 0.045). Triangular interpolation of the NN interval histogram (TINN) of long-term HRV in the PCOS group was also lower (303.9 ± 19.23 vs. 355.9 ±1 0.97, p = 0.0484) TINN in all subjects was negatively correlated to the AHI, after adjusting for age, body fat percentage, and serum androgens. TINN had a negative relation with highly sensitive C-reactive protein (hsCRP), while AHI REM was positively related to hsCRP. Conclusions: Non-obese patients with PCOS showed poorer long-term TINN during sleep compared to the controls. The TINN was related to AHI and hsCRP. PCOS patients suffered from worsened cardiac nerve autonomous function that could lead to long-term cardiovascular risk during sleep even when they are not obese.

Original languageEnglish
Pages (from-to)9-21
Number of pages13
JournalNutritional Sciences Journal
Volume35
Issue number1
Publication statusPublished - Mar 2010

Fingerprint

Polycystic Ovary Syndrome
Apnea
Sleep
Heart Rate
C-Reactive Protein
Sleep Stages
Eye Movements
Arousal
Serum
Androgens
Insulin Resistance
Adipose Tissue
Body Mass Index
Homeostasis
Hormones
Control Groups

Keywords

  • Apnea-hypopnea index
  • Heart rate variability
  • Non-obese
  • Polycystic ovary syndrome
  • Polysomnography

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

@article{9d3853831cf645dbb759ab2d49350a9c,
title = "A pilot study of heart rate variability and apneic-hypopneic events in non-obese women with polycystic ovary syndrome during sleep",
abstract = "Background: Patients with polycystic ovary syndrome (PCOS) have a higher apnea-hypopnea index (AHI) than did controls. The relationship between heart rate variability (HRV) changes and apneic-hypopneic events in non-obese women with PCOS during sleep is yet to be determined. Methods: All participants (14 untreated women with PCOS and 11 age- and BMI-controlled healthy women, with mean body mass indexes of 21.51 ± 0.63 and 21.27 ± 0.66 Kg/cm 2, respectively) underwent whole-night standard polysomnographic (PSG) monitoring and assessment of serum hormone and homeostasis model assessment of insulin resistance (HOMA-IR). Short-term HRV (in different sleep stages) and long-term HRV (6-hour sleep) were obtained by a power spectral analys is. Results: The AHI and arousal index during the non-rapid eye movement stage (AHI NREM and ARI NREM) were both higher in non-obese women with PCOS than those in the control group (0.032 ± 0.028 vs. 0.698 ± 0.243 p = 0.004; 11.45 ± 0.864 vs. 8.636 ± 0.847 p = 0.045). Triangular interpolation of the NN interval histogram (TINN) of long-term HRV in the PCOS group was also lower (303.9 ± 19.23 vs. 355.9 ±1 0.97, p = 0.0484) TINN in all subjects was negatively correlated to the AHI, after adjusting for age, body fat percentage, and serum androgens. TINN had a negative relation with highly sensitive C-reactive protein (hsCRP), while AHI REM was positively related to hsCRP. Conclusions: Non-obese patients with PCOS showed poorer long-term TINN during sleep compared to the controls. The TINN was related to AHI and hsCRP. PCOS patients suffered from worsened cardiac nerve autonomous function that could lead to long-term cardiovascular risk during sleep even when they are not obese.",
keywords = "Apnea-hypopnea index, Heart rate variability, Non-obese, Polycystic ovary syndrome, Polysomnography",
author = "Yang, {Hsiao Ping} and Kang, {Jiunn Horng} and Su, {Hsiu Yueh} and Huang, {Shih Yi}",
year = "2010",
month = "3",
language = "English",
volume = "35",
pages = "9--21",
journal = "Journal of the Chinese Nutrition Society",
issn = "1011-6958",
publisher = "臺灣營養學會",
number = "1",

}

TY - JOUR

T1 - A pilot study of heart rate variability and apneic-hypopneic events in non-obese women with polycystic ovary syndrome during sleep

AU - Yang, Hsiao Ping

AU - Kang, Jiunn Horng

AU - Su, Hsiu Yueh

AU - Huang, Shih Yi

PY - 2010/3

Y1 - 2010/3

N2 - Background: Patients with polycystic ovary syndrome (PCOS) have a higher apnea-hypopnea index (AHI) than did controls. The relationship between heart rate variability (HRV) changes and apneic-hypopneic events in non-obese women with PCOS during sleep is yet to be determined. Methods: All participants (14 untreated women with PCOS and 11 age- and BMI-controlled healthy women, with mean body mass indexes of 21.51 ± 0.63 and 21.27 ± 0.66 Kg/cm 2, respectively) underwent whole-night standard polysomnographic (PSG) monitoring and assessment of serum hormone and homeostasis model assessment of insulin resistance (HOMA-IR). Short-term HRV (in different sleep stages) and long-term HRV (6-hour sleep) were obtained by a power spectral analys is. Results: The AHI and arousal index during the non-rapid eye movement stage (AHI NREM and ARI NREM) were both higher in non-obese women with PCOS than those in the control group (0.032 ± 0.028 vs. 0.698 ± 0.243 p = 0.004; 11.45 ± 0.864 vs. 8.636 ± 0.847 p = 0.045). Triangular interpolation of the NN interval histogram (TINN) of long-term HRV in the PCOS group was also lower (303.9 ± 19.23 vs. 355.9 ±1 0.97, p = 0.0484) TINN in all subjects was negatively correlated to the AHI, after adjusting for age, body fat percentage, and serum androgens. TINN had a negative relation with highly sensitive C-reactive protein (hsCRP), while AHI REM was positively related to hsCRP. Conclusions: Non-obese patients with PCOS showed poorer long-term TINN during sleep compared to the controls. The TINN was related to AHI and hsCRP. PCOS patients suffered from worsened cardiac nerve autonomous function that could lead to long-term cardiovascular risk during sleep even when they are not obese.

AB - Background: Patients with polycystic ovary syndrome (PCOS) have a higher apnea-hypopnea index (AHI) than did controls. The relationship between heart rate variability (HRV) changes and apneic-hypopneic events in non-obese women with PCOS during sleep is yet to be determined. Methods: All participants (14 untreated women with PCOS and 11 age- and BMI-controlled healthy women, with mean body mass indexes of 21.51 ± 0.63 and 21.27 ± 0.66 Kg/cm 2, respectively) underwent whole-night standard polysomnographic (PSG) monitoring and assessment of serum hormone and homeostasis model assessment of insulin resistance (HOMA-IR). Short-term HRV (in different sleep stages) and long-term HRV (6-hour sleep) were obtained by a power spectral analys is. Results: The AHI and arousal index during the non-rapid eye movement stage (AHI NREM and ARI NREM) were both higher in non-obese women with PCOS than those in the control group (0.032 ± 0.028 vs. 0.698 ± 0.243 p = 0.004; 11.45 ± 0.864 vs. 8.636 ± 0.847 p = 0.045). Triangular interpolation of the NN interval histogram (TINN) of long-term HRV in the PCOS group was also lower (303.9 ± 19.23 vs. 355.9 ±1 0.97, p = 0.0484) TINN in all subjects was negatively correlated to the AHI, after adjusting for age, body fat percentage, and serum androgens. TINN had a negative relation with highly sensitive C-reactive protein (hsCRP), while AHI REM was positively related to hsCRP. Conclusions: Non-obese patients with PCOS showed poorer long-term TINN during sleep compared to the controls. The TINN was related to AHI and hsCRP. PCOS patients suffered from worsened cardiac nerve autonomous function that could lead to long-term cardiovascular risk during sleep even when they are not obese.

KW - Apnea-hypopnea index

KW - Heart rate variability

KW - Non-obese

KW - Polycystic ovary syndrome

KW - Polysomnography

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