A Pilot Safety Assessment for Recombinant Epinephelus lanceolatus Piscidin Yeast Powder as a Drug Food Additive after Subacute and Subchronic Administration to SD Rats

Bor Chyuan Su, Chao Chin Li, Chia Wen Liu, Jyh Yih Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Recombinant Epinephelus lanceolatus piscidin (RELP) was previously shown to improve growth performance and immune response when used as a feed additive for Gallus gallus domesticus. However, the long-term toxicity of RELP has not be thoroughly investigated. In the present study, we evaluated the subacute and subchronic oral toxicities of RELP in SD rats by hematological, biochemical, and histopathological analyses. To determine subacute and subchronic toxicities, male and female rats were fed with RELP 1000 mg/kg bodyweight/day for 28 and 90 days, respectively. Bodyweight and food intake were unchanged by RELP treatment over the course of the studies. After exposure, samples of blood, heart, lung, liver, and kidney were collected and analyzed. Results demonstrated that RELP exposure did not cause any observable hematological, biochemical, or histological abnormalities in SD rats. Thus, RELP may be a safe feed additive for use in agriculture and aquaculture.

Original languageEnglish
JournalMarine Drugs
Volume18
Issue number12
DOIs
Publication statusPublished - Nov 24 2020

Keywords

  • recombinant Epinephelus lanceolatus piscidin
  • safety assessment
  • SD rats
  • subacute toxicity
  • subchronic toxicity
  • yeast powder

ASJC Scopus subject areas

  • Drug Discovery

Fingerprint Dive into the research topics of 'A Pilot Safety Assessment for Recombinant Epinephelus lanceolatus Piscidin Yeast Powder as a Drug Food Additive after Subacute and Subchronic Administration to SD Rats'. Together they form a unique fingerprint.

Cite this