A novel strategy by using synovial membranes, cartilage fragments and mesenchymal stem cells for cartilage tissue engineering: A novel strategy for cartilage tissue engineering

Chia Chun Chen, Jia Si Hu, Hsu Wei Fang, Chih Hung Chang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In this study, we used cartilage fragments, synovial membranes and bone marrow-derived mesenchymal stem cells to mimic a knee joint environment for cartilage tissue engineering. SEM images showed that MSCs attached and grew well in the constructs and exhibited polygonal cell morphologies. Histological analyses revealed that the constructs showed round cell appearances with positive Alcian blue staining. After 28 days of in-vitro culture, the gene expressions of type II collagen were significantly increased. Therefore, we suggested that the constructs containing cartilage fragments, synovial membranes and MSCs resulted in better outcomes for chondrogenesis. This might be a novel strategy for articular cartilage repair and regeneration.

Original languageEnglish
Title of host publicationProceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012
Pages965-967
Number of pages3
DOIs
Publication statusPublished - Oct 1 2012
Externally publishedYes
Event2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012 - Macau, China
Duration: May 28 2012May 30 2012

Publication series

NameProceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012

Conference

Conference2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012
CountryChina
CityMacau
Period5/28/125/30/12

Keywords

  • bone marrow-derived mesenchymal stem cells
  • cartilage fragments
  • synovial membranesg

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

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  • Cite this

    Chen, C. C., Hu, J. S., Fang, H. W., & Chang, C. H. (2012). A novel strategy by using synovial membranes, cartilage fragments and mesenchymal stem cells for cartilage tissue engineering: A novel strategy for cartilage tissue engineering. In Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012 (pp. 965-967). [6245283] (Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012). https://doi.org/10.1109/iCBEB.2012.35