A novel strategy by using synovial membranes, cartilage fragments and mesenchymal stem cells for cartilage tissue engineering: A novel strategy for cartilage tissue engineering

Chia Chun Chen, Jia Si Hu, Hsu Wei Fang, Chih Hung Chang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

In this study, we used cartilage fragments, synovial membranes and bone marrow-derived mesenchymal stem cells to mimic a knee joint environment for cartilage tissue engineering. SEM images showed that MSCs attached and grew well in the constructs and exhibited polygonal cell morphologies. Histological analyses revealed that the constructs showed round cell appearances with positive Alcian blue staining. After 28 days of in-vitro culture, the gene expressions of type II collagen were significantly increased. Therefore, we suggested that the constructs containing cartilage fragments, synovial membranes and MSCs resulted in better outcomes for chondrogenesis. This might be a novel strategy for articular cartilage repair and regeneration.

Original languageEnglish
Title of host publicationProceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012
Pages965-967
Number of pages3
DOIs
Publication statusPublished - Oct 1 2012
Externally publishedYes
Event2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012 - Macau, China
Duration: May 28 2012May 30 2012

Publication series

NameProceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012

Conference

Conference2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012
CountryChina
CityMacau
Period5/28/125/30/12

Fingerprint

Synovial Membrane
Cartilage
Tissue Engineering
Stem cells
Mesenchymal Stromal Cells
Tissue engineering
Membranes
Chondrogenesis
Alcian Blue
Collagen Type II
Articular Cartilage
Knee Joint
Regeneration
Bone Marrow
Collagen
Gene expression
Staining and Labeling
Gene Expression
Bone
Repair

Keywords

  • bone marrow-derived mesenchymal stem cells
  • cartilage fragments
  • synovial membranesg

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

Cite this

Chen, C. C., Hu, J. S., Fang, H. W., & Chang, C. H. (2012). A novel strategy by using synovial membranes, cartilage fragments and mesenchymal stem cells for cartilage tissue engineering: A novel strategy for cartilage tissue engineering. In Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012 (pp. 965-967). [6245283] (Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012). https://doi.org/10.1109/iCBEB.2012.35

A novel strategy by using synovial membranes, cartilage fragments and mesenchymal stem cells for cartilage tissue engineering : A novel strategy for cartilage tissue engineering. / Chen, Chia Chun; Hu, Jia Si; Fang, Hsu Wei; Chang, Chih Hung.

Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012. 2012. p. 965-967 6245283 (Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chen, CC, Hu, JS, Fang, HW & Chang, CH 2012, A novel strategy by using synovial membranes, cartilage fragments and mesenchymal stem cells for cartilage tissue engineering: A novel strategy for cartilage tissue engineering. in Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012., 6245283, Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012, pp. 965-967, 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012, Macau, China, 5/28/12. https://doi.org/10.1109/iCBEB.2012.35
Chen CC, Hu JS, Fang HW, Chang CH. A novel strategy by using synovial membranes, cartilage fragments and mesenchymal stem cells for cartilage tissue engineering: A novel strategy for cartilage tissue engineering. In Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012. 2012. p. 965-967. 6245283. (Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012). https://doi.org/10.1109/iCBEB.2012.35
Chen, Chia Chun ; Hu, Jia Si ; Fang, Hsu Wei ; Chang, Chih Hung. / A novel strategy by using synovial membranes, cartilage fragments and mesenchymal stem cells for cartilage tissue engineering : A novel strategy for cartilage tissue engineering. Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012. 2012. pp. 965-967 (Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012).
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