A novel single nucleotide polymorphism in XRCC4 gene is associated with gastric cancer susceptibility in Taiwan

Chang Fang Chiu, Chung Hsing Wang, Cheng Li Wang, Cheng Chieh Lin, Nan Yung Hsu, Jing Ru Weng, Da Tian Bau

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Background: The DNA repair gene XRCC4, an important caretaker of the overall genome stability, is thought to play a major role in the human carcinogenesis. We investigate some novel and important polymorphic variants of XRCC4, at codon 247 (rs3734091), G-1394T (rs6869366), intron 3 (rs28360071), and intron 7 (rs28360317), of their associated with gastric cancer susceptibility. Materials and Methods: In this hospital-based case-control study, the association of XRCC4 polymorphisms with gastric cancer risk in a Taiwanese population was investigated. In total, 121 patients with gastric cancer and 121 age-matched healthy controls recruited were genotyped investigating these polymorphisms' association with gastric cancer susceptibility. Results: We found a significant difference in the frequency of the XRCC4 G-1394T genotype, but not others, between the gastric cancer and control groups. Those who had G/T or G/G at XRCC4 G-1394T showed a 3.79-fold (95% confidence interval = 1.47-9.82) increased risk of gastric cancer compared to those with T/T. As for XRCC4 codon 247, intron 3, or intron 7, there was no difference in distribution between the gastric cancer and control groups. Conclusions: Our findings suggest that the G allele of the XRCC4 G-1394T may contribute to gastric carcinogenesis and may be useful for gastric cancer early detection and prevention.

Original languageEnglish
Pages (from-to)514-518
Number of pages5
JournalAnnals of Surgical Oncology
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 2008
Externally publishedYes

Keywords

  • Carcinogenesis
  • Gastric cancer
  • Polymorphism
  • XRCC4

ASJC Scopus subject areas

  • Surgery
  • Oncology

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