A novel resorbable α-calcium sulfate hemihydrate/amorphous calcium phosphate bone substitute for dental implantation surgery

Hong Da Wu, Sheng Yang Lee, Malosi Poma, Jia Yo Wu, Duen Cheng Wang, Jen Chang Yang

Research output: Contribution to journalArticle

15 Citations (Scopus)


The purpose of this study was to prepare resorbable α-calcium sulfate hemihydrate/amorphous calcium phosphate (α-CSH/ACP) bone substitute with a resorption period of 3-6 months specifically designed for dental implantation surgery. A one-pot process was used to manufacture α-CSH and ACP. Granular particles of α-CSH/ACP (60/40) with diameters of 420-840 μm were prepared. In dissolution test, both α-CSH/ACP (60/40) and CSD displayed rapid dissolution in the first 20 days, followed by a remarkably slow dissolution rate to reach weight retention plateaus of around 13.5%±0.7% and 40.5%±1.4% at 90 days, respectively. The in vivo study showed no adverse effects as a consequence of any of the implanted materials. After 3 weeks, the defects treated with α-CSH/ACP (60/40) showed more new bone formation (21.1%) than the empty control (13.6%) (p

Original languageEnglish
Pages (from-to)440-446
Number of pages7
JournalMaterials Science and Engineering C
Issue number3
Publication statusPublished - Apr 1 2012



  • α-calcium sulfate hemihydrate
  • Amorphous calcium phosphate
  • Bone graft substitute
  • Dental implant surgery
  • Resorption rate

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials

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