A novel prenylated C6-C3 compound with estrogen-like activity from the fruits of Illicium arborescens

Chia Ching Liaw, Yu Chen Chen, Ahmed Eid Fazary, Ju Liang Hsieh, Shun Ying Chen, Ching Te Chien, Shiow Yunn Sheu, Yao Haur Kuo, Bor Luen Chiang, Ya Ching Shen

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4 Citations (Scopus)

Abstract

A novel C6-C3 prenylated compound, illicarborene A (1), together with illioliganfunone D (2), 1-allyl-3,5-dimethoxy-4-(3-methylbut-2-enyloxy)benzene (3), ()-illicinone A (4), ()-illicinone B (5) and ()-illicinone A derivative (6) was isolated and characterized from the fruits of Illicium arborescens Hayata. Compound 1 possesses a new class of tricyclic 6/6/5 ring system. The structure of 1 was determined by spectroscopic analysis such as 1H-1H COSY, HMQC, HMBC, and NOESY, and confirmed by chemical reaction to yield 7. Compounds 1-5 were found to increase proliferative activity in primary cell culture of osteoblast cells.

Original languageEnglish
Pages (from-to)397-402
Number of pages6
JournalPhytochemistry Letters
Volume6
Issue number3
DOIs
Publication statusPublished - 2013

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Keywords

  • Cytotoxicity
  • Estrogen-like activity
  • Illicarborene A
  • Illicium arborescens
  • Prenylated C6-C3 compounds

ASJC Scopus subject areas

  • Plant Science
  • Agronomy and Crop Science
  • Biochemistry
  • Biotechnology

Cite this

Liaw, C. C., Chen, Y. C., Fazary, A. E., Hsieh, J. L., Chen, S. Y., Chien, C. T., Sheu, S. Y., Kuo, Y. H., Chiang, B. L., & Shen, Y. C. (2013). A novel prenylated C6-C3 compound with estrogen-like activity from the fruits of Illicium arborescens. Phytochemistry Letters, 6(3), 397-402. https://doi.org/10.1016/j.phytol.2013.04.005