A novel mechanism involved in TLR4 expression during inflammation

Chi Yuan Li, Feng Yen Lin

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The p47phox- and Rac1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs. These evidences provide for the direct involvement of VSMCs in endotoxin-mediated inflammatory activation, which may contribute to the progression of cardiovascular disorders, although targeting TLR4 will prove to be a successful approach for the treatment of these devastating diseases remains to be determined.

Original languageEnglish
Pages (from-to)63-64
Number of pages2
JournalActa Anaesthesiologica Taiwanica
Volume45
Issue number2
Publication statusPublished - Jun 2007
Externally publishedYes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Medicine(all)

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