A novel mechanism involved in TLR4 expression during inflammation

Chi Yuan Li, Feng Yen Lin

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The p47phox- and Rac1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs. These evidences provide for the direct involvement of VSMCs in endotoxin-mediated inflammatory activation, which may contribute to the progression of cardiovascular disorders, although targeting TLR4 will prove to be a successful approach for the treatment of these devastating diseases remains to be determined.

Original languageEnglish
Pages (from-to)63-64
Number of pages2
JournalActa Anaesthesiologica Taiwanica
Volume45
Issue number2
Publication statusPublished - Jun 2007
Externally publishedYes

Fingerprint

Endotoxins
Inflammation
Critical Pathways
NADPH Oxidase
Messenger RNA

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Medicine(all)

Cite this

A novel mechanism involved in TLR4 expression during inflammation. / Li, Chi Yuan; Lin, Feng Yen.

In: Acta Anaesthesiologica Taiwanica, Vol. 45, No. 2, 06.2007, p. 63-64.

Research output: Contribution to journalArticle

@article{95cab041fa404cdd868faa1c6edd6e48,
title = "A novel mechanism involved in TLR4 expression during inflammation",
abstract = "The p47phox- and Rac1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs. These evidences provide for the direct involvement of VSMCs in endotoxin-mediated inflammatory activation, which may contribute to the progression of cardiovascular disorders, although targeting TLR4 will prove to be a successful approach for the treatment of these devastating diseases remains to be determined.",
author = "Li, {Chi Yuan} and Lin, {Feng Yen}",
year = "2007",
month = "6",
language = "English",
volume = "45",
pages = "63--64",
journal = "Asian Journal of Anesthesiology",
issn = "2468-824X",
publisher = "Elsevier Taiwan LLC",
number = "2",

}

TY - JOUR

T1 - A novel mechanism involved in TLR4 expression during inflammation

AU - Li, Chi Yuan

AU - Lin, Feng Yen

PY - 2007/6

Y1 - 2007/6

N2 - The p47phox- and Rac1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs. These evidences provide for the direct involvement of VSMCs in endotoxin-mediated inflammatory activation, which may contribute to the progression of cardiovascular disorders, although targeting TLR4 will prove to be a successful approach for the treatment of these devastating diseases remains to be determined.

AB - The p47phox- and Rac1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs. These evidences provide for the direct involvement of VSMCs in endotoxin-mediated inflammatory activation, which may contribute to the progression of cardiovascular disorders, although targeting TLR4 will prove to be a successful approach for the treatment of these devastating diseases remains to be determined.

UR - http://www.scopus.com/inward/record.url?scp=34548426079&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548426079&partnerID=8YFLogxK

M3 - Article

C2 - 17694680

AN - SCOPUS:34548426079

VL - 45

SP - 63

EP - 64

JO - Asian Journal of Anesthesiology

JF - Asian Journal of Anesthesiology

SN - 2468-824X

IS - 2

ER -