The p47phox- and Rac1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs. These evidences provide for the direct involvement of VSMCs in endotoxin-mediated inflammatory activation, which may contribute to the progression of cardiovascular disorders, although targeting TLR4 will prove to be a successful approach for the treatment of these devastating diseases remains to be determined.
|Number of pages||2|
|Journal||Acta Anaesthesiologica Taiwanica|
|Publication status||Published - Jun 2007|
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine