A novel mechanism involved in TLR4 expression during inflammation

Chi Yuan Li; Feng Yen Lin

A novel mechanism involved in TLR4 expression during inflammation

Research output: Contribution to journal › Article › peer-review

Abstract

The p47^phox- and Rac1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs. These evidences provide for the direct involvement of VSMCs in endotoxin-mediated inflammatory activation, which may contribute to the progression of cardiovascular disorders, although targeting TLR4 will prove to be a successful approach for the treatment of these devastating diseases remains to be determined.

Original language	English
Pages (from-to)	63-64
Number of pages	2
Journal	Acta Anaesthesiologica Taiwanica
Volume	45
Issue number	2
Publication status	Published - Jun 2007
Externally published	Yes

ASJC Scopus subject areas

Anesthesiology and Pain Medicine
Medicine(all)

Cite this

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title = "A novel mechanism involved in TLR4 expression during inflammation",

abstract = "The p47phox- and Rac1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs. These evidences provide for the direct involvement of VSMCs in endotoxin-mediated inflammatory activation, which may contribute to the progression of cardiovascular disorders, although targeting TLR4 will prove to be a successful approach for the treatment of these devastating diseases remains to be determined.",

author = "Li, {Chi Yuan} and Lin, {Feng Yen}",

year = "2007",

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volume = "45",

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AB - The p47phox- and Rac1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs. These evidences provide for the direct involvement of VSMCs in endotoxin-mediated inflammatory activation, which may contribute to the progression of cardiovascular disorders, although targeting TLR4 will prove to be a successful approach for the treatment of these devastating diseases remains to be determined.

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A novel mechanism involved in TLR4 expression during inflammation

Abstract

ASJC Scopus subject areas

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