A novel HLA-B allele, B*58: 01:12, detected in a Taiwanese volunteer bone marrow stem cell donor using sequence-based typing method

K. L. Yang, S. K. Lee, R. H. Kao, C. L. Lin, P. Y. Lin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Human leukocyte antigen-B*58:01:12, a novel rare allele of HLA-B*58:01 variant, was found in a Taiwanese volunteer bone marrow donor by SBT (sequence-based typing) method. The DNA sequence of B*58:01:12 is identical to the sequence of B*58:01:01 in exons 2, 3 and 4 except at nucleotide position 483 where nucleotide C is substituted by T (at codon 137; GAC GAT). Due to the silent point mutation, the amino acid sequence of B*58:01:12 is identical to the sequence of B*58:01:01. The HLA haplotype in association with B*58:01:12 may be deduced as A*33:03-B*58:01:12-DRB1*03:01. The discovery of B*58:01:12 adds further polymorphism of B*58:01 in Taiwanese population.

Original languageEnglish
Pages (from-to)324-325
Number of pages2
JournalInternational Journal of Immunogenetics
Volume40
Issue number4
DOIs
Publication statusPublished - Aug 1 2013
Externally publishedYes

Fingerprint

HLA-B Antigens
Bone Marrow Cells
Volunteers
Stem Cells
Nucleotides
Alleles
Tissue Donors
HLA Antigens
Point Mutation
Codon
Haplotypes
Amino Acid Sequence
Exons
Bone Marrow
Population
Silent Mutation
GAT

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Immunology
  • Genetics(clinical)
  • Medicine(all)

Cite this

A novel HLA-B allele, B*58 : 01:12, detected in a Taiwanese volunteer bone marrow stem cell donor using sequence-based typing method. / Yang, K. L.; Lee, S. K.; Kao, R. H.; Lin, C. L.; Lin, P. Y.

In: International Journal of Immunogenetics, Vol. 40, No. 4, 01.08.2013, p. 324-325.

Research output: Contribution to journalArticle

@article{471fe6d55de942eba32d33c093392996,
title = "A novel HLA-B allele, B*58: 01:12, detected in a Taiwanese volunteer bone marrow stem cell donor using sequence-based typing method",
abstract = "Human leukocyte antigen-B*58:01:12, a novel rare allele of HLA-B*58:01 variant, was found in a Taiwanese volunteer bone marrow donor by SBT (sequence-based typing) method. The DNA sequence of B*58:01:12 is identical to the sequence of B*58:01:01 in exons 2, 3 and 4 except at nucleotide position 483 where nucleotide C is substituted by T (at codon 137; GAC GAT). Due to the silent point mutation, the amino acid sequence of B*58:01:12 is identical to the sequence of B*58:01:01. The HLA haplotype in association with B*58:01:12 may be deduced as A*33:03-B*58:01:12-DRB1*03:01. The discovery of B*58:01:12 adds further polymorphism of B*58:01 in Taiwanese population.",
author = "Yang, {K. L.} and Lee, {S. K.} and Kao, {R. H.} and Lin, {C. L.} and Lin, {P. Y.}",
year = "2013",
month = "8",
day = "1",
doi = "10.1111/iji.12008",
language = "English",
volume = "40",
pages = "324--325",
journal = "International Journal of Immunogenetics",
issn = "1744-3121",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - A novel HLA-B allele, B*58

T2 - 01:12, detected in a Taiwanese volunteer bone marrow stem cell donor using sequence-based typing method

AU - Yang, K. L.

AU - Lee, S. K.

AU - Kao, R. H.

AU - Lin, C. L.

AU - Lin, P. Y.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Human leukocyte antigen-B*58:01:12, a novel rare allele of HLA-B*58:01 variant, was found in a Taiwanese volunteer bone marrow donor by SBT (sequence-based typing) method. The DNA sequence of B*58:01:12 is identical to the sequence of B*58:01:01 in exons 2, 3 and 4 except at nucleotide position 483 where nucleotide C is substituted by T (at codon 137; GAC GAT). Due to the silent point mutation, the amino acid sequence of B*58:01:12 is identical to the sequence of B*58:01:01. The HLA haplotype in association with B*58:01:12 may be deduced as A*33:03-B*58:01:12-DRB1*03:01. The discovery of B*58:01:12 adds further polymorphism of B*58:01 in Taiwanese population.

AB - Human leukocyte antigen-B*58:01:12, a novel rare allele of HLA-B*58:01 variant, was found in a Taiwanese volunteer bone marrow donor by SBT (sequence-based typing) method. The DNA sequence of B*58:01:12 is identical to the sequence of B*58:01:01 in exons 2, 3 and 4 except at nucleotide position 483 where nucleotide C is substituted by T (at codon 137; GAC GAT). Due to the silent point mutation, the amino acid sequence of B*58:01:12 is identical to the sequence of B*58:01:01. The HLA haplotype in association with B*58:01:12 may be deduced as A*33:03-B*58:01:12-DRB1*03:01. The discovery of B*58:01:12 adds further polymorphism of B*58:01 in Taiwanese population.

UR - http://www.scopus.com/inward/record.url?scp=84880135199&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880135199&partnerID=8YFLogxK

U2 - 10.1111/iji.12008

DO - 10.1111/iji.12008

M3 - Article

C2 - 23190492

AN - SCOPUS:84880135199

VL - 40

SP - 324

EP - 325

JO - International Journal of Immunogenetics

JF - International Journal of Immunogenetics

SN - 1744-3121

IS - 4

ER -