4 Citations (Scopus)

Abstract

Past studies in humans have demonstrated horizontal and vertical bone loss after six months following tooth extraction. Many biomaterials have been developed to preserve bone volume after tooth extraction. Type I collagen serves as an excellent delivery system for growth factors and promotes angiogenesis. Calcium phosphate ceramics have also been investigated because their mineral chemistry resembles human bone. The aim of this study was to compare the performance of a novel bioresorbable purified fibrillar collagen and hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) ceramic composite versus collagen alone and a bovine xenograft-collagen composite in beagles. Collagen plugs, bovine graft-collagen composite and HA/β-TCP-collagen composite were implanted into the left and right first, second and third mandibular premolars, and the fourth molar was left empty for natural healing. In total, 20 male beagle dogs were used, and quantitative and histological analyses of the extraction ridge was done. The smallest width reduction was 19.09% ± 8.81% with the HA/β-TCP-collagen composite at Week 8, accompanied by new bone formation at Weeks 4 and 8. The HA/β-TCP-collagen composite performed well, as a new osteoconductive and biomimetic composite biomaterial, for socket bone preservation after tooth extraction.

Original languageEnglish
Article number191
JournalMaterials
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 11 2016

Fingerprint

Durapatite
Hydroxyapatite
Collagen
Bone
Phosphates
Composite materials
Biocompatible Materials
Biomaterials
Fibrillar Collagens
Biomimetics
Collagen Type I
tricalcium phosphate
Heterografts
Grafts
Minerals
Calcium phosphate
Intercellular Signaling Peptides and Proteins

Keywords

  • Allograft
  • Animal study
  • Collagen
  • Composite
  • Hydroxyapatite
  • Socket preservation
  • β-tricalcium phosphate

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

A novel HA/β-TCP-collagen composite enhanced new bone formation for dental extraction socket preservation in beagle dogs. / Ho, Ko Ning; Salamanca, Eisner; Chang, Kuo Chi; Shih, Tsai Chin; Chang, Yu Chi; Huang, Haw Ming; Teng, Nai Chia; Lin, Che Tong; Feng, Sheng-Wei; Chang, Wei Jen.

In: Materials, Vol. 9, No. 3, 191, 11.03.2016.

Research output: Contribution to journalArticle

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abstract = "Past studies in humans have demonstrated horizontal and vertical bone loss after six months following tooth extraction. Many biomaterials have been developed to preserve bone volume after tooth extraction. Type I collagen serves as an excellent delivery system for growth factors and promotes angiogenesis. Calcium phosphate ceramics have also been investigated because their mineral chemistry resembles human bone. The aim of this study was to compare the performance of a novel bioresorbable purified fibrillar collagen and hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) ceramic composite versus collagen alone and a bovine xenograft-collagen composite in beagles. Collagen plugs, bovine graft-collagen composite and HA/β-TCP-collagen composite were implanted into the left and right first, second and third mandibular premolars, and the fourth molar was left empty for natural healing. In total, 20 male beagle dogs were used, and quantitative and histological analyses of the extraction ridge was done. The smallest width reduction was 19.09{\%} ± 8.81{\%} with the HA/β-TCP-collagen composite at Week 8, accompanied by new bone formation at Weeks 4 and 8. The HA/β-TCP-collagen composite performed well, as a new osteoconductive and biomimetic composite biomaterial, for socket bone preservation after tooth extraction.",
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AU - Ho, Ko Ning

AU - Salamanca, Eisner

AU - Chang, Kuo Chi

AU - Shih, Tsai Chin

AU - Chang, Yu Chi

AU - Huang, Haw Ming

AU - Teng, Nai Chia

AU - Lin, Che Tong

AU - Feng, Sheng-Wei

AU - Chang, Wei Jen

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