A nonrandom chromosomal abnormality, del 3p(14-23), in human small cell lung cancer (SCLC)

J. Whang-Peng, P. A. Bunn, C. S. Kao-Shan, E. C. Lee, D. N. Carney, A. Gazdar, J. D. Minna

Research output: Contribution to journalArticle

293 Citations (Scopus)

Abstract

In order to determine whether or not there are specific chromosomal changes in small cell lung cancer (SCLC), karyotypic analyses of 16 continuous SCLC tissue culture lines, three fresh tumor specimens (bone marrow), one direct preparation of bone marrow involved with SCLC, and two lymphoblastoid lines derived from SCLC patients were studied. Cell lines were derived from primary tumor, or metastases to bone marrow, subcutaneous nodules, or pleural fluid; all 16 lines had biochemical and histologic proporties characteristic of SCLC. Of the 15 males and 3 females, 6 patients had no prior treatment. All of the 16 cell lines, the 3 fresh specimens, and the direct bone marrow preparation had a common deletion of the short arm of chromosome #3. Use of the shortest region of overlap analysis showed the common deletion was of the short arm in the regions p(14-23). This specific chromosomal abnormality, del 3p, was not found in five non-SCLC cell lines studied and is of major potential biological and diagnostic importance.

Original languageEnglish
Pages (from-to)119-134
Number of pages16
JournalCancer Genetics and Cytogenetics
Volume6
Issue number2
DOIs
Publication statusPublished - Jan 1 1982
Externally publishedYes

Fingerprint

Small Cell Lung Carcinoma
Chromosome Aberrations
Bone Marrow
Cell Line
Chromosomes, Human, Pair 3
Non-Small Cell Lung Carcinoma
Neoplasms
Neoplasm Metastasis

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

A nonrandom chromosomal abnormality, del 3p(14-23), in human small cell lung cancer (SCLC). / Whang-Peng, J.; Bunn, P. A.; Kao-Shan, C. S.; Lee, E. C.; Carney, D. N.; Gazdar, A.; Minna, J. D.

In: Cancer Genetics and Cytogenetics, Vol. 6, No. 2, 01.01.1982, p. 119-134.

Research output: Contribution to journalArticle

Whang-Peng, J. ; Bunn, P. A. ; Kao-Shan, C. S. ; Lee, E. C. ; Carney, D. N. ; Gazdar, A. ; Minna, J. D. / A nonrandom chromosomal abnormality, del 3p(14-23), in human small cell lung cancer (SCLC). In: Cancer Genetics and Cytogenetics. 1982 ; Vol. 6, No. 2. pp. 119-134.
@article{7abcc9df721c40c2aeb8e468a884a122,
title = "A nonrandom chromosomal abnormality, del 3p(14-23), in human small cell lung cancer (SCLC)",
abstract = "In order to determine whether or not there are specific chromosomal changes in small cell lung cancer (SCLC), karyotypic analyses of 16 continuous SCLC tissue culture lines, three fresh tumor specimens (bone marrow), one direct preparation of bone marrow involved with SCLC, and two lymphoblastoid lines derived from SCLC patients were studied. Cell lines were derived from primary tumor, or metastases to bone marrow, subcutaneous nodules, or pleural fluid; all 16 lines had biochemical and histologic proporties characteristic of SCLC. Of the 15 males and 3 females, 6 patients had no prior treatment. All of the 16 cell lines, the 3 fresh specimens, and the direct bone marrow preparation had a common deletion of the short arm of chromosome #3. Use of the shortest region of overlap analysis showed the common deletion was of the short arm in the regions p(14-23). This specific chromosomal abnormality, del 3p, was not found in five non-SCLC cell lines studied and is of major potential biological and diagnostic importance.",
author = "J. Whang-Peng and Bunn, {P. A.} and Kao-Shan, {C. S.} and Lee, {E. C.} and Carney, {D. N.} and A. Gazdar and Minna, {J. D.}",
year = "1982",
month = "1",
day = "1",
doi = "10.1016/0165-4608(82)90077-2",
language = "English",
volume = "6",
pages = "119--134",
journal = "Cancer Genetics and Cytogenetics",
issn = "0165-4608",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - A nonrandom chromosomal abnormality, del 3p(14-23), in human small cell lung cancer (SCLC)

AU - Whang-Peng, J.

AU - Bunn, P. A.

AU - Kao-Shan, C. S.

AU - Lee, E. C.

AU - Carney, D. N.

AU - Gazdar, A.

AU - Minna, J. D.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - In order to determine whether or not there are specific chromosomal changes in small cell lung cancer (SCLC), karyotypic analyses of 16 continuous SCLC tissue culture lines, three fresh tumor specimens (bone marrow), one direct preparation of bone marrow involved with SCLC, and two lymphoblastoid lines derived from SCLC patients were studied. Cell lines were derived from primary tumor, or metastases to bone marrow, subcutaneous nodules, or pleural fluid; all 16 lines had biochemical and histologic proporties characteristic of SCLC. Of the 15 males and 3 females, 6 patients had no prior treatment. All of the 16 cell lines, the 3 fresh specimens, and the direct bone marrow preparation had a common deletion of the short arm of chromosome #3. Use of the shortest region of overlap analysis showed the common deletion was of the short arm in the regions p(14-23). This specific chromosomal abnormality, del 3p, was not found in five non-SCLC cell lines studied and is of major potential biological and diagnostic importance.

AB - In order to determine whether or not there are specific chromosomal changes in small cell lung cancer (SCLC), karyotypic analyses of 16 continuous SCLC tissue culture lines, three fresh tumor specimens (bone marrow), one direct preparation of bone marrow involved with SCLC, and two lymphoblastoid lines derived from SCLC patients were studied. Cell lines were derived from primary tumor, or metastases to bone marrow, subcutaneous nodules, or pleural fluid; all 16 lines had biochemical and histologic proporties characteristic of SCLC. Of the 15 males and 3 females, 6 patients had no prior treatment. All of the 16 cell lines, the 3 fresh specimens, and the direct bone marrow preparation had a common deletion of the short arm of chromosome #3. Use of the shortest region of overlap analysis showed the common deletion was of the short arm in the regions p(14-23). This specific chromosomal abnormality, del 3p, was not found in five non-SCLC cell lines studied and is of major potential biological and diagnostic importance.

UR - http://www.scopus.com/inward/record.url?scp=0020351169&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020351169&partnerID=8YFLogxK

U2 - 10.1016/0165-4608(82)90077-2

DO - 10.1016/0165-4608(82)90077-2

M3 - Article

C2 - 6286098

AN - SCOPUS:0020351169

VL - 6

SP - 119

EP - 134

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 2

ER -