A new method for converting nitriles into primary thioamides by sodium trimethylsilanethiolate

P. Y. Lin, W. S. Ku, M. J. Shiao

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A new method was developed for converting nitriles into primary thioamides. Treatment of various nitriles 1 with 1.5-2.5 equivalents of sodium trimethylsilyl sulfide (sodium trimethylsilanethiolate) in 1,3-dimethyl-2-imidazolidinone at 20-35°C for 4-30 hours gave the corresponding thioamides 2 in 27-80% yield.

Original languageEnglish
Pages (from-to)1219-1220
Number of pages2
JournalSynthesis
Issue number12
Publication statusPublished - 1992
Externally publishedYes

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Thioamides
Nitriles
Sodium

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

A new method for converting nitriles into primary thioamides by sodium trimethylsilanethiolate. / Lin, P. Y.; Ku, W. S.; Shiao, M. J.

In: Synthesis, No. 12, 1992, p. 1219-1220.

Research output: Contribution to journalArticle

Lin, P. Y. ; Ku, W. S. ; Shiao, M. J. / A new method for converting nitriles into primary thioamides by sodium trimethylsilanethiolate. In: Synthesis. 1992 ; No. 12. pp. 1219-1220.
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