A new method for converting nitriles into primary thioamides by sodium trimethylsilanethiolate

P. Y. Lin, W. S. Ku, M. J. Shiao

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Abstract

A new method was developed for converting nitriles into primary thioamides. Treatment of various nitriles 1 with 1.5-2.5 equivalents of sodium trimethylsilyl sulfide (sodium trimethylsilanethiolate) in 1,3-dimethyl-2-imidazolidinone at 20-35°C for 4-30 hours gave the corresponding thioamides 2 in 27-80% yield.

Original languageEnglish
Pages (from-to)1219-1220
Number of pages2
JournalSynthesis
Issue number12
Publication statusPublished - 1992
Externally publishedYes

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ASJC Scopus subject areas

  • Organic Chemistry

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