A new ferulic acid ester, a new ellagic acid derivative, and other constituents from Pachycentria formosana: Effects on neutrophil pro-inflammatory responses

Jui Ying Cho, Zong-Huei Li, Tsong Long Hwang, Sheng Zehn Yang, Ih Sheng Chen, Tsung Hsien Chou, Ping Jyun Sung, Jih Jung Chen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A new ferulic acid ester derivative, tetracosane-1,24-diyl di[(Z)-ferulate] (1), and a new ellagic acid derivative, 3,4:3′,4′-bis(O,O- methylene)ellagic acid (2), have been isolated from leaves and twigs of Pachycentria formosana, together with eight known compounds. Their structures were determined by in-depth spectroscopic and mass-spectrometric analyses. Among the isolated compounds, oleanolic acid (6), ursolic acid acetate (7), and 3-epibetulinic acid (9) exhibited potent inhibition (IC 50 values ≤21.8μM) of O 2 ·- generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/ cytochalasin B (fMLP/CB). In addition, oleanolic acid (6), 3-O-[(E)-feruloyl] ursolic acid (8), 3-epibetulinic acid (9), and lawsonic acid (10) also inhibited fMLP/CB-induced elastase release with IC 50 values ≤ 18.6μM.

Original languageEnglish
Pages (from-to)1709-1716
Number of pages8
JournalChemistry and Biodiversity
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 2011

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Keywords

  • Ellagic acid
  • Ferulic acid ester
  • Neutrophil pro-inflammatory responses
  • Pachycentria formosana

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Bioengineering
  • Molecular Biology
  • Molecular Medicine

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