A new ferulic acid ester, a new ellagic acid derivative, and other constituents from Pachycentria formosana: Effects on neutrophil pro-inflammatory responses

Jui Ying Cho, Zong-Huei Li, Tsong Long Hwang, Sheng Zehn Yang, Ih Sheng Chen, Tsung Hsien Chou, Ping Jyun Sung, Jih Jung Chen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A new ferulic acid ester derivative, tetracosane-1,24-diyl di[(Z)-ferulate] (1), and a new ellagic acid derivative, 3,4:3′,4′-bis(O,O- methylene)ellagic acid (2), have been isolated from leaves and twigs of Pachycentria formosana, together with eight known compounds. Their structures were determined by in-depth spectroscopic and mass-spectrometric analyses. Among the isolated compounds, oleanolic acid (6), ursolic acid acetate (7), and 3-epibetulinic acid (9) exhibited potent inhibition (IC 50 values ≤21.8μM) of O 2 ·- generation by human neutrophils in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine/ cytochalasin B (fMLP/CB). In addition, oleanolic acid (6), 3-O-[(E)-feruloyl] ursolic acid (8), 3-epibetulinic acid (9), and lawsonic acid (10) also inhibited fMLP/CB-induced elastase release with IC 50 values ≤ 18.6μM.

Original languageEnglish
Pages (from-to)1709-1716
Number of pages8
JournalChemistry and Biodiversity
Volume8
Issue number9
DOIs
Publication statusPublished - Sep 2011

Fingerprint

ferulic acid
Ellagic acid
Ellagic Acid
leucyl-phenylalanine
Oleanolic Acid
Esters
Cytochalasin B
Neutrophils
Derivatives
Phenylalanine
Acids
Pancreatic Elastase
Acetates

Keywords

  • Ellagic acid
  • Ferulic acid ester
  • Neutrophil pro-inflammatory responses
  • Pachycentria formosana

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Bioengineering
  • Molecular Biology
  • Molecular Medicine

Cite this

A new ferulic acid ester, a new ellagic acid derivative, and other constituents from Pachycentria formosana : Effects on neutrophil pro-inflammatory responses. / Cho, Jui Ying; Li, Zong-Huei; Hwang, Tsong Long; Yang, Sheng Zehn; Chen, Ih Sheng; Chou, Tsung Hsien; Sung, Ping Jyun; Chen, Jih Jung.

In: Chemistry and Biodiversity, Vol. 8, No. 9, 09.2011, p. 1709-1716.

Research output: Contribution to journalArticle

Cho, Jui Ying ; Li, Zong-Huei ; Hwang, Tsong Long ; Yang, Sheng Zehn ; Chen, Ih Sheng ; Chou, Tsung Hsien ; Sung, Ping Jyun ; Chen, Jih Jung. / A new ferulic acid ester, a new ellagic acid derivative, and other constituents from Pachycentria formosana : Effects on neutrophil pro-inflammatory responses. In: Chemistry and Biodiversity. 2011 ; Vol. 8, No. 9. pp. 1709-1716.
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