A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata

Zong-Huei Li, Ching Kuo Lee, Wan Lin Tsou, Sheng Yung Liu, Mao Tien Kuo, Wu Che Wen

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Antroquinonol (1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evaluated against MCF-7, MDA-MB-231 (human breast carcinoma), Hep3B, HepG2 (human liver carcinoma) and DU-145, LNCaP (human prostate carcinoma) cell lines, and the IC50 values ranged from 0.13 ± 0.02 to 6.09 ± 0.07 μM.

Original languageEnglish
Pages (from-to)1412-1415
Number of pages4
JournalPlanta Medica
Issue number13
Publication statusPublished - Oct 2007


ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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