A new γ-lactone from the leaves of Cinnamomum kotoense

Sien Sing Yang, Wen Chi Hou, Li Wei Huang, Zong-Huei Li

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A new C 19 γ-lactone, cinnakotolactone (1), along with a known analogue, isolinderanolide B (2), were isolated from the n-hexane layer of the leaf extracts of Cinnamomum kotoense. Their structures were elucidated on the basis of spectroscopic analysis. The anti-proliferation activities of 1 and 2 were evaluated against human HT29 and MCF-7 cancer cell lines, and their IC 50 values ranged from 3.3 ± 0.3 to 25.8 ± 5.3 μM.

Original languageEnglish
Pages (from-to)1246-1250
Number of pages5
JournalNatural Product Research
Volume20
Issue number13
DOIs
Publication statusPublished - Nov 2006

Fingerprint

Cinnamomum
Spectroscopic analysis
MCF-7 Cells
Lactones
lactones
leaf extracts
hexane
inhibitory concentration 50
Cells
cell lines
Cell Line
leaves
Neoplasms
neoplasm cells
isolinderanolide B
n-hexane

Keywords

  • Anti-proliferation activity
  • Cinnakotolactone
  • Cinnamomum kotoense
  • Lauraceae
  • Leaves

ASJC Scopus subject areas

  • Molecular Medicine
  • Plant Science
  • Chemistry(all)
  • Biochemistry

Cite this

A new γ-lactone from the leaves of Cinnamomum kotoense. / Yang, Sien Sing; Hou, Wen Chi; Huang, Li Wei; Li, Zong-Huei.

In: Natural Product Research, Vol. 20, No. 13, 11.2006, p. 1246-1250.

Research output: Contribution to journalArticle

Yang, Sien Sing ; Hou, Wen Chi ; Huang, Li Wei ; Li, Zong-Huei. / A new γ-lactone from the leaves of Cinnamomum kotoense. In: Natural Product Research. 2006 ; Vol. 20, No. 13. pp. 1246-1250.
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