A neuronal fiber tracking study for major depressive disorder using MR diffusion tensor imaging with fiber tractography

2010 International Conference on Bioinformatics and Biomedical Technology, ICBBT 2010

Chia-Feng Lu, Shin Teng, Yu-Te Wu, Po-Shan Wang, Tze-Chen Yeh, Tung-Ping Su, Jen-Chuen Hsieh, Int. Assoc. Comput. Sci. Inf. Technol. (IACSIT)

Research output: Contribution to conferenceOther

3 Citations (Scopus)

Abstract

Diffusion tensor imaging (DTI) had been proved to be a powerful tool to investigate the white matter integrity and visualize the neuronal axons in vivo. Most of the DTI-based studies mainly used the region-of-interest approach to investigate the abnormalities in areas of white matter tracts involved in mood regulation for patients with major depressive disorder (MDD). In this study, we explored the structure of the fiber connections in whole-brain white matter for both major depressive patients and healthy subjects based on the DTI tractography. With the automatic anatomical labeling (AAL) process, each individual brain can be partitioned into ninety regions in normalized space so that the number of the connected fibers and histograms of the fiber lengths between any paired regions can be estimated. Twenty-three MDD patients and twenty-four age and gender-matched normal subjects were recruited. Our results concluded that: 1) the numbers of connected fibers revealed significant increase (pvalue <0.005) in the MDD group compared with the normal group in mood-regulation related region pairs consisting of right superior frontal gyrus to right pallidum, right putamen to right precuneus, left pallidum to left precuneus, left superior parietal gyrus to right superior occipital gyrus, left middle occipital gyrus to right middle temporal gyrus, and both side lingual gyrus to both side superior temporal gyrus. Only two region pairs manifested significant decrease (p-value <0.005) in patient group, which were right insula to right superior temporal gyrus, and right precuneus to right inferior temporal gyrus; 2) the distributions of the connected fiber lengths for the detected region pairs with the increasing or decreasing fibers in MDD group were between 10 to 30 mm. © 2010 IEEE.
Original languageEnglish
Pages106-110
Number of pages5
DOIs
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Biomedical Technology
Diffusion Tensor Imaging
Major Depressive Disorder
Temporal Lobe
Computational Biology
Occipital Lobe
Parietal Lobe
Globus Pallidus
Putamen
Brain
Prefrontal Cortex
Axons
Healthy Volunteers
White Matter

Keywords

  • Diffusion tensor imaging
  • DTI-based axonal mapping
  • Fiber tractography
  • Major depressive disorder
  • Anatomical labeling
  • DTI tractography
  • Fiber connections
  • Fiber length
  • Healthy subjects
  • In-vivo
  • MR-diffusion
  • Neuronal fibers
  • P-values
  • Region-of-interest approach
  • Superior temporal gyrus
  • Temporal gyrus
  • White matter
  • White matter tracts
  • Bioinformatics
  • Diffusion
  • Fibers
  • Image segmentation
  • Information dissemination
  • Tensors

Cite this

A neuronal fiber tracking study for major depressive disorder using MR diffusion tensor imaging with fiber tractography : 2010 International Conference on Bioinformatics and Biomedical Technology, ICBBT 2010. / Lu, Chia-Feng; Teng, Shin; Wu, Yu-Te; Wang, Po-Shan; Yeh, Tze-Chen; Su, Tung-Ping; Hsieh, Jen-Chuen; (IACSIT), Int. Assoc. Comput. Sci. Inf. Technol.

2010. 106-110.

Research output: Contribution to conferenceOther

Lu, Chia-Feng ; Teng, Shin ; Wu, Yu-Te ; Wang, Po-Shan ; Yeh, Tze-Chen ; Su, Tung-Ping ; Hsieh, Jen-Chuen ; (IACSIT), Int. Assoc. Comput. Sci. Inf. Technol. / A neuronal fiber tracking study for major depressive disorder using MR diffusion tensor imaging with fiber tractography : 2010 International Conference on Bioinformatics and Biomedical Technology, ICBBT 2010. 5 p.
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title = "A neuronal fiber tracking study for major depressive disorder using MR diffusion tensor imaging with fiber tractography: 2010 International Conference on Bioinformatics and Biomedical Technology, ICBBT 2010",
abstract = "Diffusion tensor imaging (DTI) had been proved to be a powerful tool to investigate the white matter integrity and visualize the neuronal axons in vivo. Most of the DTI-based studies mainly used the region-of-interest approach to investigate the abnormalities in areas of white matter tracts involved in mood regulation for patients with major depressive disorder (MDD). In this study, we explored the structure of the fiber connections in whole-brain white matter for both major depressive patients and healthy subjects based on the DTI tractography. With the automatic anatomical labeling (AAL) process, each individual brain can be partitioned into ninety regions in normalized space so that the number of the connected fibers and histograms of the fiber lengths between any paired regions can be estimated. Twenty-three MDD patients and twenty-four age and gender-matched normal subjects were recruited. Our results concluded that: 1) the numbers of connected fibers revealed significant increase (pvalue <0.005) in the MDD group compared with the normal group in mood-regulation related region pairs consisting of right superior frontal gyrus to right pallidum, right putamen to right precuneus, left pallidum to left precuneus, left superior parietal gyrus to right superior occipital gyrus, left middle occipital gyrus to right middle temporal gyrus, and both side lingual gyrus to both side superior temporal gyrus. Only two region pairs manifested significant decrease (p-value <0.005) in patient group, which were right insula to right superior temporal gyrus, and right precuneus to right inferior temporal gyrus; 2) the distributions of the connected fiber lengths for the detected region pairs with the increasing or decreasing fibers in MDD group were between 10 to 30 mm. {\circledC} 2010 IEEE.",
keywords = "Diffusion tensor imaging, DTI-based axonal mapping, Fiber tractography, Major depressive disorder, Anatomical labeling, DTI tractography, Fiber connections, Fiber length, Healthy subjects, In-vivo, MR-diffusion, Neuronal fibers, P-values, Region-of-interest approach, Superior temporal gyrus, Temporal gyrus, White matter, White matter tracts, Bioinformatics, Diffusion, Fibers, Image segmentation, Information dissemination, Tensors",
author = "Chia-Feng Lu and Shin Teng and Yu-Te Wu and Po-Shan Wang and Tze-Chen Yeh and Tung-Ping Su and Jen-Chuen Hsieh and (IACSIT), {Int. Assoc. Comput. Sci. Inf. Technol.}",
note = "會議代碼: 81050 被引用次數:3 Export Date: 31 March 2016 通訊地址: Lu, C.-F.; Dept. of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan; 電子郵件: alvin4016@yahoo.com.tw 參考文獻: White, T., Nelson, M., Lim, K.O., Diffusion tensor imaging in psychiatric disorders (2008) Top Magn Reson Imaging, 19, pp. 97-109; Mori, S., Crain, B.J., Chacko, V.P., Van Zijl, P.C.M., Threedimensional tracking of axonal projections in the brain by magnetic resonance imaging (1999) Ann. Neurol., 45 (2), pp. 265-269; Conturo, T.E., Lori, N.F., Cull, T.S., Akbudak, E., Snyder, A.Z., Shimony, J.S., McKinstry, R.C., Raichle, M.E., Tracking neuronal fiber pathways in the living human brain (1999) Proc. Natl. Acad. Sci. U.S.A. Appl. Phys. Sci., Neurobiol., 96 (18), pp. 10422-10427; Mori, S., Kaufmann, W., Davatzikos, C., Stieltjes, B., Amodei, L., Fredericksen, K., Pearlson, G., Van Zijl, P., Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking (2002) Magn. Reson. Med., 47 (2), pp. 215-223; Jiang, H., Van Zijl, M.P.C., Kim, J., Pearlson, G.D., Mori, S., DtiStudio: Resource program for diffusion tensor computation and fiber bundle tracking (2006) Computer Methods and Programs in Biomedicine, 81 (2), pp. 106-116; Tzourio-Mazoyer, N., Landeau, N., Papathanassiou, B., Crivello, D., Etard, F., Delcroix, O., Mazoyer, B., Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain (2002) NeuroImage, 15, pp. 273-289; Li, L., Ma, N., Li, Z., Tan, L., Liu, J., Gong, G., Shu, N., Xu, L., Prefrontal white matter abnormalities in young adult with major depressive disorder: A diffusion tensor imaging study (2007) Brain Research, 1168 (1), pp. 124-128. , DOI 10.1016/j.brainres.2007.06.094, PII S0006899307016393; Matsuo, K., Rosenberg, D.R., Easter, P.C., MacMaster, F.P., Chen, H.H., Nicoletti, M., Striatal volume abnormalities in treatment- Naive patients diagnosed with pediatric major depressive disorder (2008) Journal of Child and Adolescent Psychopharmacology, 18, pp. 121-131; Haldane, M., Frangou, S., Functional neuroimaging studies in mood disorders (2006) Acta Neuropsychiatrica, 18, pp. 88-89; Smith, G.S., Kramer, E., Hermann, C., Ma, Y., Dhawan, V., Chaly, T., Eidelberg, D., Serotonin modulation of cerebral glucose metabolism in depressed older adults (2009) Biol. Psychiatry, 66, pp. 259-266",
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doi = "10.1109/ICBBT.2010.5479001",
language = "English",
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TY - CONF

T1 - A neuronal fiber tracking study for major depressive disorder using MR diffusion tensor imaging with fiber tractography

T2 - 2010 International Conference on Bioinformatics and Biomedical Technology, ICBBT 2010

AU - Lu, Chia-Feng

AU - Teng, Shin

AU - Wu, Yu-Te

AU - Wang, Po-Shan

AU - Yeh, Tze-Chen

AU - Su, Tung-Ping

AU - Hsieh, Jen-Chuen

AU - (IACSIT), Int. Assoc. Comput. Sci. Inf. Technol.

N1 - 會議代碼: 81050 被引用次數:3 Export Date: 31 March 2016 通訊地址: Lu, C.-F.; Dept. of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan; 電子郵件: alvin4016@yahoo.com.tw 參考文獻: White, T., Nelson, M., Lim, K.O., Diffusion tensor imaging in psychiatric disorders (2008) Top Magn Reson Imaging, 19, pp. 97-109; Mori, S., Crain, B.J., Chacko, V.P., Van Zijl, P.C.M., Threedimensional tracking of axonal projections in the brain by magnetic resonance imaging (1999) Ann. Neurol., 45 (2), pp. 265-269; Conturo, T.E., Lori, N.F., Cull, T.S., Akbudak, E., Snyder, A.Z., Shimony, J.S., McKinstry, R.C., Raichle, M.E., Tracking neuronal fiber pathways in the living human brain (1999) Proc. Natl. Acad. Sci. U.S.A. Appl. Phys. Sci., Neurobiol., 96 (18), pp. 10422-10427; Mori, S., Kaufmann, W., Davatzikos, C., Stieltjes, B., Amodei, L., Fredericksen, K., Pearlson, G., Van Zijl, P., Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking (2002) Magn. Reson. Med., 47 (2), pp. 215-223; Jiang, H., Van Zijl, M.P.C., Kim, J., Pearlson, G.D., Mori, S., DtiStudio: Resource program for diffusion tensor computation and fiber bundle tracking (2006) Computer Methods and Programs in Biomedicine, 81 (2), pp. 106-116; Tzourio-Mazoyer, N., Landeau, N., Papathanassiou, B., Crivello, D., Etard, F., Delcroix, O., Mazoyer, B., Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain (2002) NeuroImage, 15, pp. 273-289; Li, L., Ma, N., Li, Z., Tan, L., Liu, J., Gong, G., Shu, N., Xu, L., Prefrontal white matter abnormalities in young adult with major depressive disorder: A diffusion tensor imaging study (2007) Brain Research, 1168 (1), pp. 124-128. , DOI 10.1016/j.brainres.2007.06.094, PII S0006899307016393; Matsuo, K., Rosenberg, D.R., Easter, P.C., MacMaster, F.P., Chen, H.H., Nicoletti, M., Striatal volume abnormalities in treatment- Naive patients diagnosed with pediatric major depressive disorder (2008) Journal of Child and Adolescent Psychopharmacology, 18, pp. 121-131; Haldane, M., Frangou, S., Functional neuroimaging studies in mood disorders (2006) Acta Neuropsychiatrica, 18, pp. 88-89; Smith, G.S., Kramer, E., Hermann, C., Ma, Y., Dhawan, V., Chaly, T., Eidelberg, D., Serotonin modulation of cerebral glucose metabolism in depressed older adults (2009) Biol. Psychiatry, 66, pp. 259-266

PY - 2010

Y1 - 2010

N2 - Diffusion tensor imaging (DTI) had been proved to be a powerful tool to investigate the white matter integrity and visualize the neuronal axons in vivo. Most of the DTI-based studies mainly used the region-of-interest approach to investigate the abnormalities in areas of white matter tracts involved in mood regulation for patients with major depressive disorder (MDD). In this study, we explored the structure of the fiber connections in whole-brain white matter for both major depressive patients and healthy subjects based on the DTI tractography. With the automatic anatomical labeling (AAL) process, each individual brain can be partitioned into ninety regions in normalized space so that the number of the connected fibers and histograms of the fiber lengths between any paired regions can be estimated. Twenty-three MDD patients and twenty-four age and gender-matched normal subjects were recruited. Our results concluded that: 1) the numbers of connected fibers revealed significant increase (pvalue <0.005) in the MDD group compared with the normal group in mood-regulation related region pairs consisting of right superior frontal gyrus to right pallidum, right putamen to right precuneus, left pallidum to left precuneus, left superior parietal gyrus to right superior occipital gyrus, left middle occipital gyrus to right middle temporal gyrus, and both side lingual gyrus to both side superior temporal gyrus. Only two region pairs manifested significant decrease (p-value <0.005) in patient group, which were right insula to right superior temporal gyrus, and right precuneus to right inferior temporal gyrus; 2) the distributions of the connected fiber lengths for the detected region pairs with the increasing or decreasing fibers in MDD group were between 10 to 30 mm. © 2010 IEEE.

AB - Diffusion tensor imaging (DTI) had been proved to be a powerful tool to investigate the white matter integrity and visualize the neuronal axons in vivo. Most of the DTI-based studies mainly used the region-of-interest approach to investigate the abnormalities in areas of white matter tracts involved in mood regulation for patients with major depressive disorder (MDD). In this study, we explored the structure of the fiber connections in whole-brain white matter for both major depressive patients and healthy subjects based on the DTI tractography. With the automatic anatomical labeling (AAL) process, each individual brain can be partitioned into ninety regions in normalized space so that the number of the connected fibers and histograms of the fiber lengths between any paired regions can be estimated. Twenty-three MDD patients and twenty-four age and gender-matched normal subjects were recruited. Our results concluded that: 1) the numbers of connected fibers revealed significant increase (pvalue <0.005) in the MDD group compared with the normal group in mood-regulation related region pairs consisting of right superior frontal gyrus to right pallidum, right putamen to right precuneus, left pallidum to left precuneus, left superior parietal gyrus to right superior occipital gyrus, left middle occipital gyrus to right middle temporal gyrus, and both side lingual gyrus to both side superior temporal gyrus. Only two region pairs manifested significant decrease (p-value <0.005) in patient group, which were right insula to right superior temporal gyrus, and right precuneus to right inferior temporal gyrus; 2) the distributions of the connected fiber lengths for the detected region pairs with the increasing or decreasing fibers in MDD group were between 10 to 30 mm. © 2010 IEEE.

KW - Diffusion tensor imaging

KW - DTI-based axonal mapping

KW - Fiber tractography

KW - Major depressive disorder

KW - Anatomical labeling

KW - DTI tractography

KW - Fiber connections

KW - Fiber length

KW - Healthy subjects

KW - In-vivo

KW - MR-diffusion

KW - Neuronal fibers

KW - P-values

KW - Region-of-interest approach

KW - Superior temporal gyrus

KW - Temporal gyrus

KW - White matter

KW - White matter tracts

KW - Bioinformatics

KW - Diffusion

KW - Fibers

KW - Image segmentation

KW - Information dissemination

KW - Tensors

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