A myelodysplastic syndrome with marrow eosinophilia terminating in acute nonlymphocytic leukemia, associated with an abnormal chromosome 16

S. L. Abbondanzo, R. G. Gray, J. Whang-Peng, R. J. Jacobson

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A patient presented with a myelodysplastic syndrome and bone marrow eosinophilia that evolved six months later into an acute nonlymphocytic leukemia (ANLL). Cytogenetic analyses of the bone marrow revealed 86% of the metaphases with 45,X-Y,inv(16)(p13;q22),t(11;17)(q11;q25),del(21)(q13) and 14% of the metaphases with the same abnormalities but with a Y chromosome. The association of ANLL, bone marrow eosinophilia, and abnormal chromosome 16 has previously been reported and has been suggested to have a favorable prognosis. Our patient is unique in that ANLL was preceded by a preleukemic phase associated with bone marrow eosinophilia. When complete remission was achieved, the bone marrow cytogenetics returned to normal, and the eosinophilia disappeared.

Original languageEnglish
Pages (from-to)330-332
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume111
Issue number4
Publication statusPublished - Jan 1 1987
Externally publishedYes

Fingerprint

Chromosomes, Human, Pair 16
Myelodysplastic Syndromes
Eosinophilia
Acute Myeloid Leukemia
Bone Marrow
Metaphase
Y Chromosome
Cytogenetic Analysis
Cytogenetics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

A myelodysplastic syndrome with marrow eosinophilia terminating in acute nonlymphocytic leukemia, associated with an abnormal chromosome 16. / Abbondanzo, S. L.; Gray, R. G.; Whang-Peng, J.; Jacobson, R. J.

In: Archives of Pathology and Laboratory Medicine, Vol. 111, No. 4, 01.01.1987, p. 330-332.

Research output: Contribution to journalArticle

@article{e7db290cbdd444f0a15d6505fb17176b,
title = "A myelodysplastic syndrome with marrow eosinophilia terminating in acute nonlymphocytic leukemia, associated with an abnormal chromosome 16",
abstract = "A patient presented with a myelodysplastic syndrome and bone marrow eosinophilia that evolved six months later into an acute nonlymphocytic leukemia (ANLL). Cytogenetic analyses of the bone marrow revealed 86{\%} of the metaphases with 45,X-Y,inv(16)(p13;q22),t(11;17)(q11;q25),del(21)(q13) and 14{\%} of the metaphases with the same abnormalities but with a Y chromosome. The association of ANLL, bone marrow eosinophilia, and abnormal chromosome 16 has previously been reported and has been suggested to have a favorable prognosis. Our patient is unique in that ANLL was preceded by a preleukemic phase associated with bone marrow eosinophilia. When complete remission was achieved, the bone marrow cytogenetics returned to normal, and the eosinophilia disappeared.",
author = "Abbondanzo, {S. L.} and Gray, {R. G.} and J. Whang-Peng and Jacobson, {R. J.}",
year = "1987",
month = "1",
day = "1",
language = "English",
volume = "111",
pages = "330--332",
journal = "Archives of Pathology and Laboratory Medicine",
issn = "0003-9985",
publisher = "College of American Pathologists",
number = "4",

}

TY - JOUR

T1 - A myelodysplastic syndrome with marrow eosinophilia terminating in acute nonlymphocytic leukemia, associated with an abnormal chromosome 16

AU - Abbondanzo, S. L.

AU - Gray, R. G.

AU - Whang-Peng, J.

AU - Jacobson, R. J.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - A patient presented with a myelodysplastic syndrome and bone marrow eosinophilia that evolved six months later into an acute nonlymphocytic leukemia (ANLL). Cytogenetic analyses of the bone marrow revealed 86% of the metaphases with 45,X-Y,inv(16)(p13;q22),t(11;17)(q11;q25),del(21)(q13) and 14% of the metaphases with the same abnormalities but with a Y chromosome. The association of ANLL, bone marrow eosinophilia, and abnormal chromosome 16 has previously been reported and has been suggested to have a favorable prognosis. Our patient is unique in that ANLL was preceded by a preleukemic phase associated with bone marrow eosinophilia. When complete remission was achieved, the bone marrow cytogenetics returned to normal, and the eosinophilia disappeared.

AB - A patient presented with a myelodysplastic syndrome and bone marrow eosinophilia that evolved six months later into an acute nonlymphocytic leukemia (ANLL). Cytogenetic analyses of the bone marrow revealed 86% of the metaphases with 45,X-Y,inv(16)(p13;q22),t(11;17)(q11;q25),del(21)(q13) and 14% of the metaphases with the same abnormalities but with a Y chromosome. The association of ANLL, bone marrow eosinophilia, and abnormal chromosome 16 has previously been reported and has been suggested to have a favorable prognosis. Our patient is unique in that ANLL was preceded by a preleukemic phase associated with bone marrow eosinophilia. When complete remission was achieved, the bone marrow cytogenetics returned to normal, and the eosinophilia disappeared.

UR - http://www.scopus.com/inward/record.url?scp=0023179215&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023179215&partnerID=8YFLogxK

M3 - Article

C2 - 3469939

AN - SCOPUS:0023179215

VL - 111

SP - 330

EP - 332

JO - Archives of Pathology and Laboratory Medicine

JF - Archives of Pathology and Laboratory Medicine

SN - 0003-9985

IS - 4

ER -