A model for tumor cell killing by topoisomerase poisons

H. Zhang, P. D'Arpa, Leroy-Fong Liu

Research output: Contribution to journalArticle

172 Citations (Scopus)

Abstract

Our model proposes that topoisomerase-targeting antitumor drugs form reversible drug-enzyme-DNA complexes that collide with the DNA and RNA synthesis machineries. On collisions, the complexes lose their reversibility, and generate lethal double-strand DNA breaks. Further investigations of topoisomerase action will allow this model to be refined, and may ultimately lead to the development of more effective anticancer drugs.

Original languageEnglish
Pages (from-to)23-26
Number of pages4
JournalCancer Cells
Volume2
Issue number1
Publication statusPublished - 1990
Externally publishedYes

Fingerprint

Poisons
Double-Stranded DNA Breaks
DNA
Pharmaceutical Preparations
Antineoplastic Agents
Neoplasms
RNA
Enzymes

ASJC Scopus subject areas

  • Cancer Research

Cite this

A model for tumor cell killing by topoisomerase poisons. / Zhang, H.; D'Arpa, P.; Liu, Leroy-Fong.

In: Cancer Cells, Vol. 2, No. 1, 1990, p. 23-26.

Research output: Contribution to journalArticle

Zhang, H, D'Arpa, P & Liu, L-F 1990, 'A model for tumor cell killing by topoisomerase poisons', Cancer Cells, vol. 2, no. 1, pp. 23-26.
Zhang, H. ; D'Arpa, P. ; Liu, Leroy-Fong. / A model for tumor cell killing by topoisomerase poisons. In: Cancer Cells. 1990 ; Vol. 2, No. 1. pp. 23-26.
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