Abstract

Asthma is a disease about lower respiratory tract inflammation. A global survey shows that there are about 230 million people with asthma. Asthma is an important issue of public health in the developed and developing countries. We propose a stretchable microfluidic bronchial chip made by polydimethylsiloxane (PDMS) and glass for studying the effects of cell stretching in asthma in vitro. The bronchial smooth muscle cells (BSMC) were cultured on microfluidic chip under a continuous stretching and release mimicking human breathing. Stretching device consists of 3D printer components, a servo motor and a control panel. We have demonstrated that regular stretching of cells affect its properties. We performed stretching of cells with 13% elongation in 15 cycle per minute for 2 days. The stretching affected cell alignment of bronchial smooth muscle cells. We observed that direction of cell growth and cell stretching direction are perpendicular to each other.

Original languageEnglish
Title of host publicationNEMS 2018 - 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages36-39
Number of pages4
ISBN (Electronic)9781538652732
DOIs
Publication statusPublished - Dec 3 2018
Event13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2018 - Singapore, Singapore
Duration: Apr 22 2018Apr 26 2018

Conference

Conference13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2018
CountrySingapore
CitySingapore
Period4/22/184/26/18

Keywords

  • bronchial muscle cells
  • Cell stretching
  • Microfluidics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Electrical and Electronic Engineering
  • Instrumentation

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