Abstract

Asthma is a disease about lower respiratory tract inflammation. A global survey shows that there are about 230 million people with asthma. Asthma is an important issue of public health in the developed and developing countries. We propose a stretchable microfluidic bronchial chip made by polydimethylsiloxane (PDMS) and glass for studying the effects of cell stretching in asthma in vitro. The bronchial smooth muscle cells (BSMC) were cultured on microfluidic chip under a continuous stretching and release mimicking human breathing. Stretching device consists of 3D printer components, a servo motor and a control panel. We have demonstrated that regular stretching of cells affect its properties. We performed stretching of cells with 13% elongation in 15 cycle per minute for 2 days. The stretching affected cell alignment of bronchial smooth muscle cells. We observed that direction of cell growth and cell stretching direction are perpendicular to each other.

Original languageEnglish
Title of host publicationNEMS 2018 - 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages36-39
Number of pages4
ISBN (Electronic)9781538652732
DOIs
Publication statusPublished - Dec 3 2018
Event13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2018 - Singapore, Singapore
Duration: Apr 22 2018Apr 26 2018

Conference

Conference13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2018
CountrySingapore
CitySingapore
Period4/22/184/26/18

Fingerprint

smooth muscle
muscle cells
Microfluidics
Stretching
Muscle
asthma
Cells
cells
3D printers
chips
control boards
public health
printers
Cell growth
Public health
Polydimethylsiloxane
breathing
Developing countries
elongation
Elongation

Keywords

  • bronchial muscle cells
  • Cell stretching
  • Microfluidics

ASJC Scopus subject areas

  • Biomedical Engineering
  • Electrical and Electronic Engineering
  • Instrumentation

Cite this

Sung, C. H., Chan, Y. F., Lee, K. Y., Wu, S. M., & Liu, C. H. (2018). A Microfluidic Approach for Studying Responses of Bronchial Smooth Muscle Cells Stretching. In NEMS 2018 - 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems (pp. 36-39). [8556978] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NEMS.2018.8556978

A Microfluidic Approach for Studying Responses of Bronchial Smooth Muscle Cells Stretching. / Sung, Chun Hui; Chan, Yao Fei; Lee, Kang Yun; Wu, Sheng Ming; Liu, Cheng Hsien.

NEMS 2018 - 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems. Institute of Electrical and Electronics Engineers Inc., 2018. p. 36-39 8556978.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sung, CH, Chan, YF, Lee, KY, Wu, SM & Liu, CH 2018, A Microfluidic Approach for Studying Responses of Bronchial Smooth Muscle Cells Stretching. in NEMS 2018 - 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems., 8556978, Institute of Electrical and Electronics Engineers Inc., pp. 36-39, 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2018, Singapore, Singapore, 4/22/18. https://doi.org/10.1109/NEMS.2018.8556978
Sung CH, Chan YF, Lee KY, Wu SM, Liu CH. A Microfluidic Approach for Studying Responses of Bronchial Smooth Muscle Cells Stretching. In NEMS 2018 - 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems. Institute of Electrical and Electronics Engineers Inc. 2018. p. 36-39. 8556978 https://doi.org/10.1109/NEMS.2018.8556978
Sung, Chun Hui ; Chan, Yao Fei ; Lee, Kang Yun ; Wu, Sheng Ming ; Liu, Cheng Hsien. / A Microfluidic Approach for Studying Responses of Bronchial Smooth Muscle Cells Stretching. NEMS 2018 - 13th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems. Institute of Electrical and Electronics Engineers Inc., 2018. pp. 36-39
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