A method to determine the utility of the third diagnostic and the second follow-up sputum smear examinations to diagnose tuberculosis cases and failures

Hans L. Rieder, C. Y. Chiang, I. D. Rusen

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

SETTING: Forty-two laboratories in four countries. OBJECTIVE: To determine the number of sputum smear examinations required to identify one additional case of tuberculosis from a third serial diagnostic smear or one additional treatment failure from a second serial follow-up smear. MATERIAL AND METHODS: Country-specific prevalence of new cases and failures among 59 665 examinees were determined, as well as the incremental yield from serial smears. The reciprocal value of the product of the prevalence of cases or failures and the respective incremental yield from the last serial smear provided the number of slides that have to be examined to identify one additional case or failure. RESULTS: The expected prevalence of cases among suspects ranged from 5.4% to 32.8%; the incremental yield from a third serial smear ranged from 0.7% to 7.2%. Between 122.7 and 796.3 smears were required to identify one additional case with the third serial smear. The prevalence of failures among follow-up examinees ranged from 1.0% to 2.5%; the incremental yield from the second follow-up serial smear ranged from 4.5% to 26.9%. Between 164.8 and 2133.4 slides were required to identify one additional failure with the second serial smear. CONCLUSION: The utility of serial smears can be rationally determined by careful review of program data.

Original languageEnglish
Pages (from-to)384-391
Number of pages8
JournalInternational Journal of Tuberculosis and Lung Disease
Volume9
Issue number4
Publication statusPublished - Apr 2005
Externally publishedYes

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Sputum
Tuberculosis
Treatment Failure

Keywords

  • Incremental yield
  • Laboratory
  • Microscopy
  • Resources
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

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title = "A method to determine the utility of the third diagnostic and the second follow-up sputum smear examinations to diagnose tuberculosis cases and failures",
abstract = "SETTING: Forty-two laboratories in four countries. OBJECTIVE: To determine the number of sputum smear examinations required to identify one additional case of tuberculosis from a third serial diagnostic smear or one additional treatment failure from a second serial follow-up smear. MATERIAL AND METHODS: Country-specific prevalence of new cases and failures among 59 665 examinees were determined, as well as the incremental yield from serial smears. The reciprocal value of the product of the prevalence of cases or failures and the respective incremental yield from the last serial smear provided the number of slides that have to be examined to identify one additional case or failure. RESULTS: The expected prevalence of cases among suspects ranged from 5.4{\%} to 32.8{\%}; the incremental yield from a third serial smear ranged from 0.7{\%} to 7.2{\%}. Between 122.7 and 796.3 smears were required to identify one additional case with the third serial smear. The prevalence of failures among follow-up examinees ranged from 1.0{\%} to 2.5{\%}; the incremental yield from the second follow-up serial smear ranged from 4.5{\%} to 26.9{\%}. Between 164.8 and 2133.4 slides were required to identify one additional failure with the second serial smear. CONCLUSION: The utility of serial smears can be rationally determined by careful review of program data.",
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N2 - SETTING: Forty-two laboratories in four countries. OBJECTIVE: To determine the number of sputum smear examinations required to identify one additional case of tuberculosis from a third serial diagnostic smear or one additional treatment failure from a second serial follow-up smear. MATERIAL AND METHODS: Country-specific prevalence of new cases and failures among 59 665 examinees were determined, as well as the incremental yield from serial smears. The reciprocal value of the product of the prevalence of cases or failures and the respective incremental yield from the last serial smear provided the number of slides that have to be examined to identify one additional case or failure. RESULTS: The expected prevalence of cases among suspects ranged from 5.4% to 32.8%; the incremental yield from a third serial smear ranged from 0.7% to 7.2%. Between 122.7 and 796.3 smears were required to identify one additional case with the third serial smear. The prevalence of failures among follow-up examinees ranged from 1.0% to 2.5%; the incremental yield from the second follow-up serial smear ranged from 4.5% to 26.9%. Between 164.8 and 2133.4 slides were required to identify one additional failure with the second serial smear. CONCLUSION: The utility of serial smears can be rationally determined by careful review of program data.

AB - SETTING: Forty-two laboratories in four countries. OBJECTIVE: To determine the number of sputum smear examinations required to identify one additional case of tuberculosis from a third serial diagnostic smear or one additional treatment failure from a second serial follow-up smear. MATERIAL AND METHODS: Country-specific prevalence of new cases and failures among 59 665 examinees were determined, as well as the incremental yield from serial smears. The reciprocal value of the product of the prevalence of cases or failures and the respective incremental yield from the last serial smear provided the number of slides that have to be examined to identify one additional case or failure. RESULTS: The expected prevalence of cases among suspects ranged from 5.4% to 32.8%; the incremental yield from a third serial smear ranged from 0.7% to 7.2%. Between 122.7 and 796.3 smears were required to identify one additional case with the third serial smear. The prevalence of failures among follow-up examinees ranged from 1.0% to 2.5%; the incremental yield from the second follow-up serial smear ranged from 4.5% to 26.9%. Between 164.8 and 2133.4 slides were required to identify one additional failure with the second serial smear. CONCLUSION: The utility of serial smears can be rationally determined by careful review of program data.

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