TY - JOUR
T1 - A longitudinal study of the role of patient-reported outcomes on survival prediction of palliative cancer inpatients in Taiwan
AU - Chang, Jing An
AU - Lin, Chia Chin
N1 - Funding Information:
Acknowledgments The authors would like to thank Ms. Denise Dipert for her careful review and expertise on editing this manuscript. This study was supported by the National Science Council NSC 91-2314-B-038-007.
PY - 2009/10
Y1 - 2009/10
N2 - This study explores the significance of patient-reported outcomes for predicting length of survival of palliative cancer patients. Patients were recruited upon admission to the inpatient palliative care unit. Weekly assessment of 180 terminal cancer patients was carried out throughout their survival time using the Medical Outcome Study 36-Item Short-Form Health Survey, the Taiwanese version of the M.D. Anderson Symptom Inventory (MDASI-T), the Karnofsky Performance Status (KPS), the Brief Pain Inventory, and the Brief Fatigue Inventory. Generalized estimating equations (GEE) were utilized to analyze whether the patient-reported outcomes predicted survival time. Of all patients, 64 had one assessment, 51 had two, 25 had three, and 40 had four or more assessments, up to a maximum of eight. The univariate analysis showed that gender (P∈<∈0.01), KPS (P∈<∈0.01), the physical component summary score (P∈=∈0.02), the MDASI-T total score (P∈<∈0.01), composite fatigue severity (P∈<∈0.01), and composite pain severity (P∈<∈0.01) were significantly associated with length of survival. The multivariate analysis showed that gender (P∈<∈0.01), KPS (P∈<∈0.01), and the MDASI-T total score (P∈=∈0.01) were significant predictors of survival time. This is the first study to explore the significance of patient-related outcomes for predicting length of survival of palliative cancer patients using the GEE method. This study confirms that overall symptom severity is a significant factor in assessing the length of survival of palliative cancer patients.
AB - This study explores the significance of patient-reported outcomes for predicting length of survival of palliative cancer patients. Patients were recruited upon admission to the inpatient palliative care unit. Weekly assessment of 180 terminal cancer patients was carried out throughout their survival time using the Medical Outcome Study 36-Item Short-Form Health Survey, the Taiwanese version of the M.D. Anderson Symptom Inventory (MDASI-T), the Karnofsky Performance Status (KPS), the Brief Pain Inventory, and the Brief Fatigue Inventory. Generalized estimating equations (GEE) were utilized to analyze whether the patient-reported outcomes predicted survival time. Of all patients, 64 had one assessment, 51 had two, 25 had three, and 40 had four or more assessments, up to a maximum of eight. The univariate analysis showed that gender (P∈<∈0.01), KPS (P∈<∈0.01), the physical component summary score (P∈=∈0.02), the MDASI-T total score (P∈<∈0.01), composite fatigue severity (P∈<∈0.01), and composite pain severity (P∈<∈0.01) were significantly associated with length of survival. The multivariate analysis showed that gender (P∈<∈0.01), KPS (P∈<∈0.01), and the MDASI-T total score (P∈=∈0.01) were significant predictors of survival time. This is the first study to explore the significance of patient-related outcomes for predicting length of survival of palliative cancer patients using the GEE method. This study confirms that overall symptom severity is a significant factor in assessing the length of survival of palliative cancer patients.
KW - Palliative patients
KW - Prognostic factor
KW - Quality of life
KW - Survival
KW - Symptom severity
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U2 - 10.1007/s00520-009-0583-9
DO - 10.1007/s00520-009-0583-9
M3 - Article
C2 - 19214595
AN - SCOPUS:70349323426
VL - 17
SP - 1285
EP - 1294
JO - Supportive Care in Cancer
JF - Supportive Care in Cancer
SN - 0941-4355
IS - 10
ER -
