A legume product fermented by Saccharomyces cerevisiae modulates cutaneous atopic dermatitis-like inflammation in mice

Chiou Yueh Yeh, Chiau Jing Jung, Ching Ning Huang, Ying Che Huang, Huei Ting Lien, Won Bo Wang, Li Fang Wang, Jean San Chia

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Isoflavone-containing soy products modulate allergic inflammation in mice. In our previously study, IFN-γ and IL-10 production increased in mice fed with Saccharomyces cerevisiae legume fermented product (SCLFP), demonstrating that SCLFP had immunomodulatory activity. In this study, we tested the anti-inflammatory effects of SCLFP in a mouse model of cutaneous atopic dermatitis inflammation induced by epicutaneous sensitization.Methods: Epicutaneous exposure to protein allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2-dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. The thickness of the skin epithelium, eosinophil migration, and T helper responses were determined in patched skin and draining lymph nodes of mice fed with and without SCLFP.Results: Epicutaneous exposure to protein allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2-dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. SCLFP feeding attenuated this cutaneous Th2 response, as evidenced by decreased thickening of the epidermis, less eosinophil infiltration, and lower levels of IL-5, IL-13, and CXCL11 expression compared to controls. Oral administration of SCLFP also modulated Th1 responses in draining lymph nodes, with lower levels of IFN-γ, IL-4, and IL-17 expression.Conclusion: Oral intake of SCLFP modulated the induced Th2 inflammatory responses in skin and might have potential applications for the prevention and treatment of atopic dermatitis.

Original languageEnglish
Article number194
JournalBMC Complementary and Alternative Medicine
Volume14
DOIs
Publication statusPublished - Jun 18 2014
Externally publishedYes

Fingerprint

Atopic Dermatitis
Fabaceae
Saccharomyces cerevisiae
Inflammation
Skin
Eosinophils
Allergens
Lymph Nodes
Isoflavones
Interleukin-13
Interleukin-17
Interleukin-5
Epidermis
Interleukin-4
Interleukin-10
Oral Administration
Proteins
Anti-Inflammatory Agents
Epithelium

Keywords

  • Atopic dermatitis
  • Eosinophil
  • Epicutaneous sensitization
  • Saccharomyces cerevisiae legume fermented product
  • Th2 response

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

A legume product fermented by Saccharomyces cerevisiae modulates cutaneous atopic dermatitis-like inflammation in mice. / Yeh, Chiou Yueh; Jung, Chiau Jing; Huang, Ching Ning; Huang, Ying Che; Lien, Huei Ting; Wang, Won Bo; Wang, Li Fang; Chia, Jean San.

In: BMC Complementary and Alternative Medicine, Vol. 14, 194, 18.06.2014.

Research output: Contribution to journalArticle

Yeh, Chiou Yueh ; Jung, Chiau Jing ; Huang, Ching Ning ; Huang, Ying Che ; Lien, Huei Ting ; Wang, Won Bo ; Wang, Li Fang ; Chia, Jean San. / A legume product fermented by Saccharomyces cerevisiae modulates cutaneous atopic dermatitis-like inflammation in mice. In: BMC Complementary and Alternative Medicine. 2014 ; Vol. 14.
@article{3770d85119b34dabaaa3a9a4b8067d70,
title = "A legume product fermented by Saccharomyces cerevisiae modulates cutaneous atopic dermatitis-like inflammation in mice",
abstract = "Background: Isoflavone-containing soy products modulate allergic inflammation in mice. In our previously study, IFN-γ and IL-10 production increased in mice fed with Saccharomyces cerevisiae legume fermented product (SCLFP), demonstrating that SCLFP had immunomodulatory activity. In this study, we tested the anti-inflammatory effects of SCLFP in a mouse model of cutaneous atopic dermatitis inflammation induced by epicutaneous sensitization.Methods: Epicutaneous exposure to protein allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2-dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. The thickness of the skin epithelium, eosinophil migration, and T helper responses were determined in patched skin and draining lymph nodes of mice fed with and without SCLFP.Results: Epicutaneous exposure to protein allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2-dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. SCLFP feeding attenuated this cutaneous Th2 response, as evidenced by decreased thickening of the epidermis, less eosinophil infiltration, and lower levels of IL-5, IL-13, and CXCL11 expression compared to controls. Oral administration of SCLFP also modulated Th1 responses in draining lymph nodes, with lower levels of IFN-γ, IL-4, and IL-17 expression.Conclusion: Oral intake of SCLFP modulated the induced Th2 inflammatory responses in skin and might have potential applications for the prevention and treatment of atopic dermatitis.",
keywords = "Atopic dermatitis, Eosinophil, Epicutaneous sensitization, Saccharomyces cerevisiae legume fermented product, Th2 response",
author = "Yeh, {Chiou Yueh} and Jung, {Chiau Jing} and Huang, {Ching Ning} and Huang, {Ying Che} and Lien, {Huei Ting} and Wang, {Won Bo} and Wang, {Li Fang} and Chia, {Jean San}",
year = "2014",
month = "6",
day = "18",
doi = "10.1186/1472-6882-14-194",
language = "English",
volume = "14",
journal = "BMC Complementary and Alternative Medicine",
issn = "1472-6882",
publisher = "BioMed Central",

}

TY - JOUR

T1 - A legume product fermented by Saccharomyces cerevisiae modulates cutaneous atopic dermatitis-like inflammation in mice

AU - Yeh, Chiou Yueh

AU - Jung, Chiau Jing

AU - Huang, Ching Ning

AU - Huang, Ying Che

AU - Lien, Huei Ting

AU - Wang, Won Bo

AU - Wang, Li Fang

AU - Chia, Jean San

PY - 2014/6/18

Y1 - 2014/6/18

N2 - Background: Isoflavone-containing soy products modulate allergic inflammation in mice. In our previously study, IFN-γ and IL-10 production increased in mice fed with Saccharomyces cerevisiae legume fermented product (SCLFP), demonstrating that SCLFP had immunomodulatory activity. In this study, we tested the anti-inflammatory effects of SCLFP in a mouse model of cutaneous atopic dermatitis inflammation induced by epicutaneous sensitization.Methods: Epicutaneous exposure to protein allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2-dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. The thickness of the skin epithelium, eosinophil migration, and T helper responses were determined in patched skin and draining lymph nodes of mice fed with and without SCLFP.Results: Epicutaneous exposure to protein allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2-dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. SCLFP feeding attenuated this cutaneous Th2 response, as evidenced by decreased thickening of the epidermis, less eosinophil infiltration, and lower levels of IL-5, IL-13, and CXCL11 expression compared to controls. Oral administration of SCLFP also modulated Th1 responses in draining lymph nodes, with lower levels of IFN-γ, IL-4, and IL-17 expression.Conclusion: Oral intake of SCLFP modulated the induced Th2 inflammatory responses in skin and might have potential applications for the prevention and treatment of atopic dermatitis.

AB - Background: Isoflavone-containing soy products modulate allergic inflammation in mice. In our previously study, IFN-γ and IL-10 production increased in mice fed with Saccharomyces cerevisiae legume fermented product (SCLFP), demonstrating that SCLFP had immunomodulatory activity. In this study, we tested the anti-inflammatory effects of SCLFP in a mouse model of cutaneous atopic dermatitis inflammation induced by epicutaneous sensitization.Methods: Epicutaneous exposure to protein allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2-dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. The thickness of the skin epithelium, eosinophil migration, and T helper responses were determined in patched skin and draining lymph nodes of mice fed with and without SCLFP.Results: Epicutaneous exposure to protein allergens plus Staphylococcal enterotoxin B induced a T helper (Th)-2-dominant immune response as well as cutaneous atopic dermatitis-like inflammation in BALB/c mice. SCLFP feeding attenuated this cutaneous Th2 response, as evidenced by decreased thickening of the epidermis, less eosinophil infiltration, and lower levels of IL-5, IL-13, and CXCL11 expression compared to controls. Oral administration of SCLFP also modulated Th1 responses in draining lymph nodes, with lower levels of IFN-γ, IL-4, and IL-17 expression.Conclusion: Oral intake of SCLFP modulated the induced Th2 inflammatory responses in skin and might have potential applications for the prevention and treatment of atopic dermatitis.

KW - Atopic dermatitis

KW - Eosinophil

KW - Epicutaneous sensitization

KW - Saccharomyces cerevisiae legume fermented product

KW - Th2 response

UR - http://www.scopus.com/inward/record.url?scp=84902302409&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902302409&partnerID=8YFLogxK

U2 - 10.1186/1472-6882-14-194

DO - 10.1186/1472-6882-14-194

M3 - Article

C2 - 24939647

AN - SCOPUS:84902302409

VL - 14

JO - BMC Complementary and Alternative Medicine

JF - BMC Complementary and Alternative Medicine

SN - 1472-6882

M1 - 194

ER -