Abstract
Diabetes mellitus is a common problem in developed countries. An improved postprandial hyperglycemic peak is one of the main therapeutic targets in diabetic patients. The Wistar rats with streptozotocin (STZ)-induced diabetes were divided into cornstarch (control) and Japonica rice groups, which were fed 640 g starch/kg diets for 4 weeks. The area (means ± SD) under the glucose curve of cornstarch was 173.8 ± 6.9 and Japonica rice diet was 154.3 ± 8.7 mmol × min/L, and the area (means ± SD) under the insulin curve of cornstarch was 12.9 ± 0.1 and Japonica rice diet was 12.0 ± 0.6 nmol × min/L. The glycosylated hemoglobin levels, serum fructosamine and cholesterol concentrations in diabetic rats fed the Japonica rice diet were significantly lower than the control group (P <0.05). The decreased malondialdehyde levels and increased superoxide dismutase activity and total radical-trapping antioxidant parameter in plasma were also found in rat fed the Japonica rice diet compared to the control. These results suggested that the diet containing high-resistance-starch Japonica rice might reduce glycosylated hemoglobin levels, serum cholesterol concentrations and raised the antioxidant status in the blood.
| Original language | English |
|---|---|
| Pages (from-to) | 842-847 |
| Number of pages | 6 |
| Journal | Food Research International |
| Volume | 40 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Aug 2007 |
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Keywords
- Antioxidant
- Glycosylated hemoglobin
- High-resistance-starch rice
- Streptozotocin
- Total radical-trapping antioxidant parameter
ASJC Scopus subject areas
- Food Science
Cite this
A high-resistance-starch rice diet reduces glycosylated hemoglobin levels and improves the antioxidant status in diabetic rats. / Shih, Chun Kuang; Chen, Shi Hong; Hou, Wen C.; Cheng, Hsing-Hsien.
In: Food Research International, Vol. 40, No. 7, 08.2007, p. 842-847.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A high-resistance-starch rice diet reduces glycosylated hemoglobin levels and improves the antioxidant status in diabetic rats
AU - Shih, Chun Kuang
AU - Chen, Shi Hong
AU - Hou, Wen C.
AU - Cheng, Hsing-Hsien
PY - 2007/8
Y1 - 2007/8
N2 - Diabetes mellitus is a common problem in developed countries. An improved postprandial hyperglycemic peak is one of the main therapeutic targets in diabetic patients. The Wistar rats with streptozotocin (STZ)-induced diabetes were divided into cornstarch (control) and Japonica rice groups, which were fed 640 g starch/kg diets for 4 weeks. The area (means ± SD) under the glucose curve of cornstarch was 173.8 ± 6.9 and Japonica rice diet was 154.3 ± 8.7 mmol × min/L, and the area (means ± SD) under the insulin curve of cornstarch was 12.9 ± 0.1 and Japonica rice diet was 12.0 ± 0.6 nmol × min/L. The glycosylated hemoglobin levels, serum fructosamine and cholesterol concentrations in diabetic rats fed the Japonica rice diet were significantly lower than the control group (P <0.05). The decreased malondialdehyde levels and increased superoxide dismutase activity and total radical-trapping antioxidant parameter in plasma were also found in rat fed the Japonica rice diet compared to the control. These results suggested that the diet containing high-resistance-starch Japonica rice might reduce glycosylated hemoglobin levels, serum cholesterol concentrations and raised the antioxidant status in the blood.
AB - Diabetes mellitus is a common problem in developed countries. An improved postprandial hyperglycemic peak is one of the main therapeutic targets in diabetic patients. The Wistar rats with streptozotocin (STZ)-induced diabetes were divided into cornstarch (control) and Japonica rice groups, which were fed 640 g starch/kg diets for 4 weeks. The area (means ± SD) under the glucose curve of cornstarch was 173.8 ± 6.9 and Japonica rice diet was 154.3 ± 8.7 mmol × min/L, and the area (means ± SD) under the insulin curve of cornstarch was 12.9 ± 0.1 and Japonica rice diet was 12.0 ± 0.6 nmol × min/L. The glycosylated hemoglobin levels, serum fructosamine and cholesterol concentrations in diabetic rats fed the Japonica rice diet were significantly lower than the control group (P <0.05). The decreased malondialdehyde levels and increased superoxide dismutase activity and total radical-trapping antioxidant parameter in plasma were also found in rat fed the Japonica rice diet compared to the control. These results suggested that the diet containing high-resistance-starch Japonica rice might reduce glycosylated hemoglobin levels, serum cholesterol concentrations and raised the antioxidant status in the blood.
KW - Antioxidant
KW - Glycosylated hemoglobin
KW - High-resistance-starch rice
KW - Streptozotocin
KW - Total radical-trapping antioxidant parameter
UR - http://www.scopus.com/inward/record.url?scp=34250824917&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34250824917&partnerID=8YFLogxK
U2 - 10.1016/j.foodres.2007.01.015
DO - 10.1016/j.foodres.2007.01.015
M3 - Article
AN - SCOPUS:34250824917
VL - 40
SP - 842
EP - 847
JO - Food Research International
JF - Food Research International
SN - 0963-9969
IS - 7
ER -