A high-resistance-starch rice diet reduces glycosylated hemoglobin levels and improves the antioxidant status in diabetic rats

Chun Kuang Shih, Shi Hong Chen, Wen C. Hou, Hsing-Hsien Cheng

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Diabetes mellitus is a common problem in developed countries. An improved postprandial hyperglycemic peak is one of the main therapeutic targets in diabetic patients. The Wistar rats with streptozotocin (STZ)-induced diabetes were divided into cornstarch (control) and Japonica rice groups, which were fed 640 g starch/kg diets for 4 weeks. The area (means ± SD) under the glucose curve of cornstarch was 173.8 ± 6.9 and Japonica rice diet was 154.3 ± 8.7 mmol × min/L, and the area (means ± SD) under the insulin curve of cornstarch was 12.9 ± 0.1 and Japonica rice diet was 12.0 ± 0.6 nmol × min/L. The glycosylated hemoglobin levels, serum fructosamine and cholesterol concentrations in diabetic rats fed the Japonica rice diet were significantly lower than the control group (P <0.05). The decreased malondialdehyde levels and increased superoxide dismutase activity and total radical-trapping antioxidant parameter in plasma were also found in rat fed the Japonica rice diet compared to the control. These results suggested that the diet containing high-resistance-starch Japonica rice might reduce glycosylated hemoglobin levels, serum cholesterol concentrations and raised the antioxidant status in the blood.

Original languageEnglish
Pages (from-to)842-847
Number of pages6
JournalFood Research International
Volume40
Issue number7
DOIs
Publication statusPublished - Aug 2007

Fingerprint

rice starch
Glycosylated Hemoglobin A
Starch
hemoglobin
Antioxidants
Diet
antioxidants
rice
rats
corn starch
diet
blood serum
Cholesterol
cholesterol
starch
Fructosamine
Experimental Diabetes Mellitus
streptozotocin
diabetes mellitus
Malondialdehyde

Keywords

  • Antioxidant
  • Glycosylated hemoglobin
  • High-resistance-starch rice
  • Streptozotocin
  • Total radical-trapping antioxidant parameter

ASJC Scopus subject areas

  • Food Science

Cite this

A high-resistance-starch rice diet reduces glycosylated hemoglobin levels and improves the antioxidant status in diabetic rats. / Shih, Chun Kuang; Chen, Shi Hong; Hou, Wen C.; Cheng, Hsing-Hsien.

In: Food Research International, Vol. 40, No. 7, 08.2007, p. 842-847.

Research output: Contribution to journalArticle

@article{10f46c377118468d9ee3a281e6e2f634,
title = "A high-resistance-starch rice diet reduces glycosylated hemoglobin levels and improves the antioxidant status in diabetic rats",
abstract = "Diabetes mellitus is a common problem in developed countries. An improved postprandial hyperglycemic peak is one of the main therapeutic targets in diabetic patients. The Wistar rats with streptozotocin (STZ)-induced diabetes were divided into cornstarch (control) and Japonica rice groups, which were fed 640 g starch/kg diets for 4 weeks. The area (means ± SD) under the glucose curve of cornstarch was 173.8 ± 6.9 and Japonica rice diet was 154.3 ± 8.7 mmol × min/L, and the area (means ± SD) under the insulin curve of cornstarch was 12.9 ± 0.1 and Japonica rice diet was 12.0 ± 0.6 nmol × min/L. The glycosylated hemoglobin levels, serum fructosamine and cholesterol concentrations in diabetic rats fed the Japonica rice diet were significantly lower than the control group (P <0.05). The decreased malondialdehyde levels and increased superoxide dismutase activity and total radical-trapping antioxidant parameter in plasma were also found in rat fed the Japonica rice diet compared to the control. These results suggested that the diet containing high-resistance-starch Japonica rice might reduce glycosylated hemoglobin levels, serum cholesterol concentrations and raised the antioxidant status in the blood.",
keywords = "Antioxidant, Glycosylated hemoglobin, High-resistance-starch rice, Streptozotocin, Total radical-trapping antioxidant parameter",
author = "Shih, {Chun Kuang} and Chen, {Shi Hong} and Hou, {Wen C.} and Hsing-Hsien Cheng",
year = "2007",
month = "8",
doi = "10.1016/j.foodres.2007.01.015",
language = "English",
volume = "40",
pages = "842--847",
journal = "Food Research International",
issn = "0963-9969",
publisher = "Elsevier Limited",
number = "7",

}

TY - JOUR

T1 - A high-resistance-starch rice diet reduces glycosylated hemoglobin levels and improves the antioxidant status in diabetic rats

AU - Shih, Chun Kuang

AU - Chen, Shi Hong

AU - Hou, Wen C.

AU - Cheng, Hsing-Hsien

PY - 2007/8

Y1 - 2007/8

N2 - Diabetes mellitus is a common problem in developed countries. An improved postprandial hyperglycemic peak is one of the main therapeutic targets in diabetic patients. The Wistar rats with streptozotocin (STZ)-induced diabetes were divided into cornstarch (control) and Japonica rice groups, which were fed 640 g starch/kg diets for 4 weeks. The area (means ± SD) under the glucose curve of cornstarch was 173.8 ± 6.9 and Japonica rice diet was 154.3 ± 8.7 mmol × min/L, and the area (means ± SD) under the insulin curve of cornstarch was 12.9 ± 0.1 and Japonica rice diet was 12.0 ± 0.6 nmol × min/L. The glycosylated hemoglobin levels, serum fructosamine and cholesterol concentrations in diabetic rats fed the Japonica rice diet were significantly lower than the control group (P <0.05). The decreased malondialdehyde levels and increased superoxide dismutase activity and total radical-trapping antioxidant parameter in plasma were also found in rat fed the Japonica rice diet compared to the control. These results suggested that the diet containing high-resistance-starch Japonica rice might reduce glycosylated hemoglobin levels, serum cholesterol concentrations and raised the antioxidant status in the blood.

AB - Diabetes mellitus is a common problem in developed countries. An improved postprandial hyperglycemic peak is one of the main therapeutic targets in diabetic patients. The Wistar rats with streptozotocin (STZ)-induced diabetes were divided into cornstarch (control) and Japonica rice groups, which were fed 640 g starch/kg diets for 4 weeks. The area (means ± SD) under the glucose curve of cornstarch was 173.8 ± 6.9 and Japonica rice diet was 154.3 ± 8.7 mmol × min/L, and the area (means ± SD) under the insulin curve of cornstarch was 12.9 ± 0.1 and Japonica rice diet was 12.0 ± 0.6 nmol × min/L. The glycosylated hemoglobin levels, serum fructosamine and cholesterol concentrations in diabetic rats fed the Japonica rice diet were significantly lower than the control group (P <0.05). The decreased malondialdehyde levels and increased superoxide dismutase activity and total radical-trapping antioxidant parameter in plasma were also found in rat fed the Japonica rice diet compared to the control. These results suggested that the diet containing high-resistance-starch Japonica rice might reduce glycosylated hemoglobin levels, serum cholesterol concentrations and raised the antioxidant status in the blood.

KW - Antioxidant

KW - Glycosylated hemoglobin

KW - High-resistance-starch rice

KW - Streptozotocin

KW - Total radical-trapping antioxidant parameter

UR - http://www.scopus.com/inward/record.url?scp=34250824917&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250824917&partnerID=8YFLogxK

U2 - 10.1016/j.foodres.2007.01.015

DO - 10.1016/j.foodres.2007.01.015

M3 - Article

AN - SCOPUS:34250824917

VL - 40

SP - 842

EP - 847

JO - Food Research International

JF - Food Research International

SN - 0963-9969

IS - 7

ER -