A gradient of sequence divergence in the human adult α-globin duplication units

J. F. Hess, C. W. Schmid, C. K.J. Shen

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The nucleotide sequences of the two 5′-homology blocks of human α-globin gene duplication units were determined. The sequence difference between the two blocks is essentially zero in the 5′ portions, and increases gradually toward the 3′ ends until it reaches a value of 18 percent. This gradient of sequence divergence is similar to the distribution of the frequencies of gene conversion along several loci in Ascobolus and yeast. Hot spots for initiation of gene correction processes appear to exist near the 5′ ends of the human α-globin duplication units. The data provide the physical evidence for polar gene correction process in a mammalian genome.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalScience
Volume226
Issue number4670
DOIs
Publication statusPublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'A gradient of sequence divergence in the human adult α-globin duplication units'. Together they form a unique fingerprint.

  • Cite this