A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis

Yii-Her Chou, Peng Yeong Woon, Wei-Chiao Chen, Yu-Wen Hsu, Jer-Ming Chang, Daw-Yang Hwang, Yi-Ching Chiu, Ho-Chang Kuo, Wei Pin Chang, Ming-Feng Hou, Mu-En Liu, Jan-Gowth Chang, Wei-Chiao Chang

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Abstract

Calcium nephrolithiasis is one of the most common causes of renal stones. While the prevalence of this disease has increased steadily over the last 3 decades, its pathogenesis is still unclear. Previous studies have indicated that a genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with the total serum calcium levels. In this study, we collected DNA samples from 480 Taiwanese subjects (189 calcium nephrolithiasis patients and 291 controls) for genotyping the CASR gene. Our results indicated no significant association between the CASR polymorphism (rs17251221) and the susceptibility of calcium nephrolithiasis. However, we found a significant association between rs17251221 and stone multiplicity. The risk of stone multiplicity was higher in patients with the GG+GA genotype than in those with the AA genotype (chi-square test:P = 0.008;odds ratio = 4.79;95% confidence interval, 1.44-15.92;Yates' correction for chi-square test:P = 0.013). In conclusion, our results provide evidence supporting the genetic effects of CASR on the pathogenesis of calcium nephrolithiasis.

Original languageEnglish
Article numbere25227
JournalPLoS One
Volume6
Issue number9
DOIs
Publication statusPublished - Sep 22 2011
Externally publishedYes

Fingerprint

renal calculi
Calcium-Sensing Receptors
Nephrolithiasis
Genetic Polymorphisms
Polymorphism
Genes
genetic polymorphism
Calcium
calcium
receptors
Chi-Square Distribution
genes
Genotype
pathogenesis
Odds Ratio
Confidence Intervals
Kidney
genotype
disease prevalence
DNA

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis. / Chou, Yii-Her; Woon, Peng Yeong; Chen, Wei-Chiao; Hsu, Yu-Wen; Chang, Jer-Ming; Hwang, Daw-Yang; Chiu, Yi-Ching; Kuo, Ho-Chang; Chang, Wei Pin; Hou, Ming-Feng; Liu, Mu-En; Chang, Jan-Gowth; Chang, Wei-Chiao.

In: PLoS One, Vol. 6, No. 9, e25227, 22.09.2011.

Research output: Contribution to journalArticle

Chou, Y-H, Woon, PY, Chen, W-C, Hsu, Y-W, Chang, J-M, Hwang, D-Y, Chiu, Y-C, Kuo, H-C, Chang, WP, Hou, M-F, Liu, M-E, Chang, J-G & Chang, W-C 2011, 'A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis', PLoS One, vol. 6, no. 9, e25227. https://doi.org/10.1371/journal.pone.0025227
Chou, Yii-Her ; Woon, Peng Yeong ; Chen, Wei-Chiao ; Hsu, Yu-Wen ; Chang, Jer-Ming ; Hwang, Daw-Yang ; Chiu, Yi-Ching ; Kuo, Ho-Chang ; Chang, Wei Pin ; Hou, Ming-Feng ; Liu, Mu-En ; Chang, Jan-Gowth ; Chang, Wei-Chiao. / A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis. In: PLoS One. 2011 ; Vol. 6, No. 9.
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