A family cluster of streptococcal toxic shock syndrome in children: Clinical implication and epidemiological investigation

Yhu Chering Huang, Po Ren Hsueh, Tzou Yien Lin, Dah Chin Yan, Shao Hsuan Hsia

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background. Most invasive group A streptococcal (GAS) disease occurs sporadically. Reports of family clusters of these infections are scanty, and most invasive disease occurs in adults. We describe a family cluster of streptococcal toxic shock syndrome (STSS) involving 3 children and present the results of an epidemiologic investigation. Patients and Methods. During a 16-day period, 3 children in a family developed STSS with an interval of 7 and 9 days, respectively, between the onset of disease. Cases 2 and 3 had GAS isolated from blood culture. Case 2 was fatal. Pharyngeal culture survey of the family members and schoolchildren was conducted. Antibiogram, serotyping, detection of exotoxin genes, and random amplified polymorphic DNA patterns of the disease strains and survey strains were examined. Results. One of 15 family members sampled - the sister of the index case - and 7 (5.6%) of 125 schoolchildren sampled had GAS isolated from pharyngeal cultures. Of the 10 strains examined, 2 isolates from the patients, 1 from the sister of index case, and 2 from the classmates of case 2 (the fatal case) had an identical pattern of both genotype and phenotype. Conclusion. We describe a family cluster of STSS involving 3 children caused by a single clone and provide additional data regarding invasive GAS infection subsequent to household contact. Additional studies should be conducted in conjunction with surveillance to define better the magnitude of risk in household contacts and to identify settings in which subsequent infections may occur.

Original languageEnglish
Pages (from-to)1181-1184
Number of pages4
JournalPediatrics
Volume107
Issue number5
DOIs
Publication statusPublished - May 2001
Externally publishedYes

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Septic Shock
Siblings
Exotoxins
Serotyping
Streptococcal Infections
Microbial Sensitivity Tests
Infection
Clone Cells
Genotype
Phenotype
DNA
Genes
Surveys and Questionnaires

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

A family cluster of streptococcal toxic shock syndrome in children : Clinical implication and epidemiological investigation. / Huang, Yhu Chering; Hsueh, Po Ren; Lin, Tzou Yien; Yan, Dah Chin; Hsia, Shao Hsuan.

In: Pediatrics, Vol. 107, No. 5, 05.2001, p. 1181-1184.

Research output: Contribution to journalArticle

Huang, Yhu Chering ; Hsueh, Po Ren ; Lin, Tzou Yien ; Yan, Dah Chin ; Hsia, Shao Hsuan. / A family cluster of streptococcal toxic shock syndrome in children : Clinical implication and epidemiological investigation. In: Pediatrics. 2001 ; Vol. 107, No. 5. pp. 1181-1184.
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